The role of infection in the aetiology of inflammatory bowel disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01-15

AUTHORS

Richard Hansen, John M. Thomson, Emad M. El-Omar, Georgina L. Hold

ABSTRACT

We have greatly increased our understanding of the genetics of inflammatory bowel disease (IBD) in the last decade; however, migrant studies highlight the importance of environment in disease risk. The possibility that IBD is an infection has been debated since the first description of Crohn’s disease. Mycobacterium avium paratuberculosis was the first organism to be suggested as an IBD pathogen, and it has been argued that it fulfils Koch’s postulates and could be designated the cause of Crohn’s disease. Other organisms have been postulated as possible IBD pathogens, including various Helicobacter species, one of which has been identified in primate colitis; others are widely used in animal models of IBD. Adherent-invasive Escherichia coli appear specific to ileal Crohn’s disease and have been shown to induce the release of TNF-α, a key cytokine in IBD inflammation. The aim of this article is to give a concise overview of the infections postulated as being relevant to the onset of IBD. We will also briefly cover the immunology underpinning IBD, in addition to reviewing current knowledge regarding other microorganisms that are associated with modifying the risk of developing IBD. It may be that infectious organisms have an orchestrator role in the development of dysbiosis and subsequently IBD. More... »

PAGES

266-276

References to SciGraph publications

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  • 2008-01. Inflammatory bowel disease, past, present and future: lessons from animal models in JOURNAL OF GASTROENTEROLOGY
  • 2008-12-03. An update on the use of helminths to treat Crohn’s and other autoimmunune diseases in PARASITOLOGY RESEARCH
  • 2007-07-12. Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2008-10-05. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production in NATURE
  • 2009-05-26. Candida albicans Colonization and ASCA in Familial Crohn's Disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-10-06. Inflammatory bowel disease: review from the aspect of genetics in JOURNAL OF GASTROENTEROLOGY
  • 2009-05-08. Prevalence of ulcerative colitis and Crohn’s disease in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2006-12-31. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 in NATURE GENETICS
  • 2008-05. A microbial symbiosis factor prevents intestinal inflammatory disease in NATURE
  • 1992-11. Role of human microflora in health and disease in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2007-09-25. The Genetics of Inflammatory Bowel Disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2007-07. Unravelling the pathogenesis of inflammatory bowel disease in NATURE
  • 2005-03-22. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3 in NATURE IMMUNOLOGY
  • 2009-05. The gut microbiota shapes intestinal immune responses during health and disease in NATURE REVIEWS IMMUNOLOGY
  • 1996-02. Mapping of a susceptibility locus for Crohn's disease on chromosome 16 in NATURE
  • 2007-10. Unveiling the roles of autophagy in innate and adaptive immunity in NATURE REVIEWS IMMUNOLOGY
  • 1984-12. Possible role of mycobacteria in inflammatory bowel disease in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-009-0191-y

    DOI

    http://dx.doi.org/10.1007/s00535-009-0191-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044519622

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20076977


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