Comparison between emergency and elective endoscopic sphincterotomy in patients with acute cholangitis due to choledocholithiasis: is emergency endoscopic sphincterotomy safe? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-07-14

AUTHORS

Toshiharu Ueki, Keisuke Otani, Naruhito Fujimura, Aiko Shimizu, Yuichiro Otsuka, Kenichiro Kawamoto, Toshiyuki Matsui

ABSTRACT

PurposeWe retrospectively assessed post-EST complications and examined whether combination therapy comprising endoscopic biliary drainage (EBD) plus endoscopic sphincterotomy (EST) as the initial treatment is safe in patients with acute cholangitis due to choledocholithiasis.MethodsAmong the 363 consecutive patients with acute cholangitis due to choledocholithiasis who were treated in our hospital between December 1992 and December 2006, the subjects comprised 127 patients with moderate acute cholangitis for whom EBD and EST were carried out. Factors influencing risk factors for post-EST pancreatitis, hemorrhage and hospitalization were determined by multivariate analysis.ResultsMultivariate analysis revealed that only precut sphincterotomy (PST) was a significant risk factor for post-EST pancreatitis, and the incidence of pancreatitis in patients who underwent PST was significantly higher than that in those who did not (P = 0.041). Only age was a significant risk factor for post-EST hemorrhage, and younger patients were likely to experience hemorrhage after EST (P = 0.021). Total bilirubin and the timing of EST were significant factors associated with hospitalization. Hospitalization in patients who underwent EBD plus EST as the initial treatment (emergency EST) was significantly shorter than that in those who palliatively underwent EST after EBD (elective EST; 11.8 vs. 16.2 days, P = 0.001).ConclusionsCombination therapy comprising EBD plus EST as the initial treatment for patients with moderate acute cholangitis due to choledocholithiasis was safe and did not prolong the period of hospitalization. More... »

PAGES

1080-1088

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-009-0100-4

DOI

http://dx.doi.org/10.1007/s00535-009-0100-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008566742

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19597758


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