Early biochemical response to ursodeoxycholic acid predicts symptom development in patients with asymptomatic primary biliary cirrhosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-04-16

AUTHORS

Nobuaki Azemoto, Masanori Abe, Yosuke Murata, Yoichi Hiasa, Maho Hamada, Bunzo Matsuura, Morikazu Onji

ABSTRACT

PurposeAmong patients with asymptomatic primary biliary cirrhosis (a-PBC), a substantial portion ultimately develop symptoms suggestive of liver injury. Prognostic variables to distinguish patients likely to become symptomatic from patients who will remain asymptomatic need to be identified. We examined the impact of biochemical response to ursodeoxycholic acid in the development of symptoms in patients with a-PBC.MethodsSubjects comprised 83 patients with a-PBC treated using ursodeoxycholic acid (UDCA). All patients were followed regularly every 1–3 months. Response to treatment with UDCA was defined as a decrease in γ-glutamyl transpeptidase (GGT) ≥70% of pretreatment or normal levels from 6 months after start of treatment.ResultsDuring the follow-up period (62.1 ± 52.7 months), 12 patients (14.5%) developed liver-related symptoms. Incidence of the development of liver-related symptoms was significantly higher in UDCA non-responders than in responders (p < 0.001). Multivariate analysis showed that response to UDCA (improvement of GGT) represents an independent factor for predicting symptom development in patients with a-PBC.ConclusionsPatients with a-PBC showing lack of biochemical response to UDCA by 6 months after treatment commencement should be considered for further treatments. More... »

PAGES

630-634

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-009-0051-9

DOI

http://dx.doi.org/10.1007/s00535-009-0051-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043760928

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19370305


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