Ontology type: schema:ScholarlyArticle
2008-08-17
AUTHORSYasushi Adachi, Yoshifumi Ishii, Mitsuru Yoshimoto, Yukinari Yoshida, Takao Endo, Hiroyuki Yamamoto, Hirofumi Akashi, Kohzoh Imai, Yasuhisa Shinomura, Yasuo Kato
ABSTRACTBackgroundInterstitial cells of Cajal (ICCs) are detected as a pacemaker of gastrointestinal movement and express c-kit and CD34. Recently, ICCs have implicated pathogenesis in several human diseases presenting gastrointestinal motor dysfunction. This study was performed to clarify the role of ICCs in idiopathic sigmoid megacolon using histological and immunohistochemical examinations.MethodsFour adult patients with idiopathic sigmoid megacolon and 11 controls were studied. Histology and immunocytochemistry using NSE, S100, c-kit, and CD34 were performed in conjunction with quantitative analysis using the public domain NIH image program.ResultsLittle histological change in neuromuscular structures in megacolon was observed. Immunohistochemistry demonstrated remarkable decrease of c-kit expressing ICCs without reduction of CD34 expression in the similar interstitial cell population. This observation was further supported by quantitative assessment using public domain NIH image program.ConclusionsA specific downregulation of c-kit in ICCs may be a cause of idiopathic sigmoid megacolon in adults. More... »
PAGES626-631
http://scigraph.springernature.com/pub.10.1007/s00535-008-2207-4
DOIhttp://dx.doi.org/10.1007/s00535-008-2207-4
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18709485
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