Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-08-17

AUTHORS

Yosuke Murata, Masanori Abe, Yoichi Hiasa, Nobuaki Azemoto, Teru Kumagi, Shinya Furukawa, Bunzo Matsuura, Kojiro Michitaka, Norio Horiike, Morikazu Onji

ABSTRACT

BackgroundThe course of primary biliary cirrhosis (PBC) is determined by clinical symptoms and histological findings. The present study examined the prognostic importance of imaging parameters in PBC.MethodsThe volumes of the liver and spleen of patients with PBC were assessed by computed tomography (CT). The volume ratio of liver to spleen (LV/SV ratio) was evaluated and used for further analyses.ResultsThe prognosis was significantly poorer in PBC patients with a low, rather than high, LV/SV ratio. The Cox proportional hazard regression model showed that the serum bilirubin level and the LV/SV ratio could predict the prognosis of PBC patients. In addition, the LV/SV ratio was significantly lower in patients who developed symptoms (s-PBC) than in those who remained asymptomatic (a-PBC) during the observation period.ConclusionsThe LV/SV ratio is of prognostic importance in patients with PBC. More... »

PAGES

632

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-008-2202-9

DOI

http://dx.doi.org/10.1007/s00535-008-2202-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020359771

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18709486


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