Differential modulation in the functions of intestinal dendritic cells by long- and medium-chain fatty acids View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-03

AUTHORS

Yoshikazu Tsuzuki, Jyunichi Miyazaki, Koji Matsuzaki, Yoshikiyo Okada, Ryota Hokari, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Soichiro Miura

ABSTRACT

BACKGROUND: Although dendritic cells (DCs) play significant roles in intestinal immune responses, little is known regarding the direct effects of luminal foods on DC functions in the intestinal mucosa. In this study, we examined the effects of fatty acids (FAs) with various chain length on the phagocytic function, antigen presentation, and chemotaxis of intestinal DCs. METHODS: DCs obtained from the thoracic duct lymph of mesenteric lymphadenectomized rats were cultured with long [arachidonic acid (AA) or oleic acid] or medium (octanoic acid) chain FAs with interleukin-4 and granulocyte macrophage-colony stimulating factor. Tumor necrosis factor-alpha was added in the maturation group. Phagocytic function was examined by the intake of fluorescent microbeads. The expression of cell surface molecules was determined by immunocytochemistry or fluorescence-activated cell sorting (FACS). Antigen presentation ability was evaluated by coincubating keyhole limpet hemocyanin (KLH)-sensitized spleen lymphocytes and KLH-pulsed DCs. Migratory ability of DCs toward the chemokines CC chemokine ligand (CCL) 20 and CCL21 was also assessed. RESULTS: There was a maturation-induced decrease in phagocytic function, and an increased expression of major histocompatibility complex (MHC) class II molecules. Exposure of DCs to both long- and medium-chain FAs maintained phagocytic ability. The expression of MHC class II molecules was significantly suppressed only by long-chain FAs. The expression of costimulatory factors was suppressed only by AA. Long- but not medium-chain FAs suppressed the antigen presentation ability of DCs induced by maturation. Chemotactic ability of mature DCs toward CCL21 was abrogated only by long-chain FAs. CONCLUSIONS: The data suggest that intraluminal exposure to long- and medium-chain FAs may differentially modulate the immune functions of intestinal DCs. More... »

PAGES

209-216

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-005-1747-0

DOI

http://dx.doi.org/10.1007/s00535-005-1747-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003789117

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16699854


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigen Presentation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Separation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokines, CC", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotaxis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dendritic Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens Class II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phagocytosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuzuki", 
        "givenName": "Yoshikazu", 
        "id": "sg:person.01111641416.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111641416.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyazaki", 
        "givenName": "Jyunichi", 
        "id": "sg:person.01326217527.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326217527.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuzaki", 
        "givenName": "Koji", 
        "id": "sg:person.01013636601.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013636601.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okada", 
        "givenName": "Yoshikiyo", 
        "id": "sg:person.0670627047.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670627047.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hokari", 
        "givenName": "Ryota", 
        "id": "sg:person.01216365616.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216365616.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawaguchi", 
        "givenName": "Atsushi", 
        "id": "sg:person.01041700765.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041700765.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagao", 
        "givenName": "Shigeaki", 
        "id": "sg:person.01110014165.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110014165.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itoh", 
        "givenName": "Kazuro", 
        "id": "sg:person.016344126032.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016344126032.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miura", 
        "givenName": "Soichiro", 
        "id": "sg:person.01053170647.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053170647.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/eji.1830180107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001640516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200502000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007683872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200502000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007683872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20031244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010293587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1997.v112.pm9041243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010956157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(00)82361-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011197747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12475701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012627250", 
          "https://doi.org/10.1111/1523-1747.ep12475701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0603250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021551150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.191.8.1381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028849956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2000.0779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029045371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80059-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030055641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.7.839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033089077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.27.16709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036296905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.11.1545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038430820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041439773", 
          "https://doi.org/10.1038/nature01726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041439773", 
          "https://doi.org/10.1038/nature01726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1078/0171-2985-00094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042494440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-0844(200001/03)18:1<47::aid-cbf848>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042521593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-4141(200203)32:3<742::aid-immu742>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043966493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.0022-202x.2004.23229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047698383", 
          "https://doi.org/10.1111/j.0022-202x.2004.23229.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0802-699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048481793", 
          "https://doi.org/10.1038/ni0802-699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0802-699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048481793", 
          "https://doi.org/10.1038/ni0802-699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049106469", 
          "https://doi.org/10.1038/86373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049106469", 
          "https://doi.org/10.1038/86373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.8.2869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050211608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-199700001-00032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-199700001-00032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-199700001-00032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074548961", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.165.6.3301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074694865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/130.11.2636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074719436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/131.11.2943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074950364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.5.2255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075002192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.9.4446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075039338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.3.1326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075090486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077764007", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.3.9.2501132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078940298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079504286", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081631680", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082528778", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.53.4.420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082650107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/63.5.741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082880685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.62.6.771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083185193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.64.2.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083309208"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-03", 
    "datePublishedReg": "2006-03-01", 
    "description": "BACKGROUND: Although dendritic cells (DCs) play significant roles in intestinal immune responses, little is known regarding the direct effects of luminal foods on DC functions in the intestinal mucosa. In this study, we examined the effects of fatty acids (FAs) with various chain length on the phagocytic function, antigen presentation, and chemotaxis of intestinal DCs.\nMETHODS: DCs obtained from the thoracic duct lymph of mesenteric lymphadenectomized rats were cultured with long [arachidonic acid (AA) or oleic acid] or medium (octanoic acid) chain FAs with interleukin-4 and granulocyte macrophage-colony stimulating factor. Tumor necrosis factor-alpha was added in the maturation group. Phagocytic function was examined by the intake of fluorescent microbeads. The expression of cell surface molecules was determined by immunocytochemistry or fluorescence-activated cell sorting (FACS). Antigen presentation ability was evaluated by coincubating keyhole limpet hemocyanin (KLH)-sensitized spleen lymphocytes and KLH-pulsed DCs. Migratory ability of DCs toward the chemokines CC chemokine ligand (CCL) 20 and CCL21 was also assessed.\nRESULTS: There was a maturation-induced decrease in phagocytic function, and an increased expression of major histocompatibility complex (MHC) class II molecules. Exposure of DCs to both long- and medium-chain FAs maintained phagocytic ability. The expression of MHC class II molecules was significantly suppressed only by long-chain FAs. The expression of costimulatory factors was suppressed only by AA. Long- but not medium-chain FAs suppressed the antigen presentation ability of DCs induced by maturation. Chemotactic ability of mature DCs toward CCL21 was abrogated only by long-chain FAs.\nCONCLUSIONS: The data suggest that intraluminal exposure to long- and medium-chain FAs may differentially modulate the immune functions of intestinal DCs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00535-005-1747-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1009747", 
        "issn": [
          "0944-1174", 
          "1435-5922"
        ], 
        "name": "Journal of Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "name": "Differential modulation in the functions of intestinal dendritic cells by long- and medium-chain fatty acids", 
    "pagination": "209-216", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "120d1412674277cf5bc36f9484ac9be40a578e6443a258d84d9cb18870be8713"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16699854"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9430794"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00535-005-1747-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003789117"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00535-005-1747-0", 
      "https://app.dimensions.ai/details/publication/pub.1003789117"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13078_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00535-005-1747-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00535-005-1747-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00535-005-1747-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00535-005-1747-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00535-005-1747-0'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      82 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00535-005-1747-0 schema:about N1709c47548554f25bcf8033115ae6c4a
2 N3074eac02b664667be5c019444bb0a29
3 N3633a60b0294461e8ba85cf07d66ac81
4 N3e9cbb8d5beb4e54871a25d547a0271f
5 N47b0eea4d0a742a398013a42d44b3b0c
6 N660d5fa014f545e2849bc0840ea9acce
7 N6d887642324d45888776a0c219b92ff7
8 N6e0c7df6bcd64701b9d25351860c48b0
9 N9b419d5fed6f4a1c9f95666696467eca
10 N9eba4b6fcd0141e3864fda2b00fc0400
11 Nb340d60e419b42248d0d2c58533de2da
12 Nc42ddfc6502d41a59806f4569ca6cb0d
13 Ncf7eeebd58df44a8bc63e52d129d3e61
14 Ne209b79d86454cf58b7890cd3114cb73
15 Nf03ccd970fa44a34b5e004a18e1447c3
16 anzsrc-for:11
17 anzsrc-for:1107
18 schema:author Nd6d745f1a1de46fbae6e11e5fabb91d6
19 schema:citation sg:pub.10.1038/86373
20 sg:pub.10.1038/nature01726
21 sg:pub.10.1038/ni0802-699
22 sg:pub.10.1111/1523-1747.ep12475701
23 sg:pub.10.1111/j.0022-202x.2004.23229.x
24 https://app.dimensions.ai/details/publication/pub.1074548961
25 https://app.dimensions.ai/details/publication/pub.1077764007
26 https://app.dimensions.ai/details/publication/pub.1079504286
27 https://app.dimensions.ai/details/publication/pub.1081631680
28 https://app.dimensions.ai/details/publication/pub.1082528778
29 https://doi.org/10.1002/(sici)1099-0844(200001/03)18:1<47::aid-cbf848>3.0.co;2-8
30 https://doi.org/10.1002/1521-4141(200203)32:3<742::aid-immu742>3.0.co;2-9
31 https://doi.org/10.1002/eji.1830180107
32 https://doi.org/10.1002/jlb.53.4.420
33 https://doi.org/10.1002/jlb.62.6.771
34 https://doi.org/10.1002/jlb.64.2.235
35 https://doi.org/10.1016/s0016-5085(00)82361-6
36 https://doi.org/10.1016/s0092-8674(00)80059-8
37 https://doi.org/10.1053/gast.1997.v112.pm9041243
38 https://doi.org/10.1074/jbc.272.27.16709
39 https://doi.org/10.1078/0171-2985-00094
40 https://doi.org/10.1084/jem.191.8.1381
41 https://doi.org/10.1084/jem.192.11.1545
42 https://doi.org/10.1084/jem.193.7.839
43 https://doi.org/10.1084/jem.20031244
44 https://doi.org/10.1093/ajcn/63.5.741
45 https://doi.org/10.1093/jn/130.11.2636
46 https://doi.org/10.1093/jn/131.11.2943
47 https://doi.org/10.1096/fasebj.3.9.2501132
48 https://doi.org/10.1097/00004836-199700001-00032
49 https://doi.org/10.1097/00054725-200502000-00009
50 https://doi.org/10.1098/rstb.2000.0779
51 https://doi.org/10.1182/blood.v99.8.2869
52 https://doi.org/10.1189/jlb.0603250
53 https://doi.org/10.4049/jimmunol.165.6.3301
54 https://doi.org/10.4049/jimmunol.168.5.2255
55 https://doi.org/10.4049/jimmunol.168.9.4446
56 https://doi.org/10.4049/jimmunol.169.3.1326
57 schema:datePublished 2006-03
58 schema:datePublishedReg 2006-03-01
59 schema:description BACKGROUND: Although dendritic cells (DCs) play significant roles in intestinal immune responses, little is known regarding the direct effects of luminal foods on DC functions in the intestinal mucosa. In this study, we examined the effects of fatty acids (FAs) with various chain length on the phagocytic function, antigen presentation, and chemotaxis of intestinal DCs. METHODS: DCs obtained from the thoracic duct lymph of mesenteric lymphadenectomized rats were cultured with long [arachidonic acid (AA) or oleic acid] or medium (octanoic acid) chain FAs with interleukin-4 and granulocyte macrophage-colony stimulating factor. Tumor necrosis factor-alpha was added in the maturation group. Phagocytic function was examined by the intake of fluorescent microbeads. The expression of cell surface molecules was determined by immunocytochemistry or fluorescence-activated cell sorting (FACS). Antigen presentation ability was evaluated by coincubating keyhole limpet hemocyanin (KLH)-sensitized spleen lymphocytes and KLH-pulsed DCs. Migratory ability of DCs toward the chemokines CC chemokine ligand (CCL) 20 and CCL21 was also assessed. RESULTS: There was a maturation-induced decrease in phagocytic function, and an increased expression of major histocompatibility complex (MHC) class II molecules. Exposure of DCs to both long- and medium-chain FAs maintained phagocytic ability. The expression of MHC class II molecules was significantly suppressed only by long-chain FAs. The expression of costimulatory factors was suppressed only by AA. Long- but not medium-chain FAs suppressed the antigen presentation ability of DCs induced by maturation. Chemotactic ability of mature DCs toward CCL21 was abrogated only by long-chain FAs. CONCLUSIONS: The data suggest that intraluminal exposure to long- and medium-chain FAs may differentially modulate the immune functions of intestinal DCs.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N8404016e3ccd4df086a2385136e9dd53
64 N8ade4be787f94f3e991ae5380122c6a6
65 sg:journal.1009747
66 schema:name Differential modulation in the functions of intestinal dendritic cells by long- and medium-chain fatty acids
67 schema:pagination 209-216
68 schema:productId N53844e73d0be4ea2a17578a35230bc60
69 N92899148d3de4283a1ef18b7ec1ff5e4
70 Ned72b413c111477db836c6c59cc386c9
71 Nf21b71bf9b164a0c8d68bb25ad0621f6
72 Nfa5b15c135bf4eed94801961c39ef3e6
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003789117
74 https://doi.org/10.1007/s00535-005-1747-0
75 schema:sdDatePublished 2019-04-11T14:27
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N61c4312ff36e4cd6812efcae41abd57d
78 schema:url http://link.springer.com/10.1007%2Fs00535-005-1747-0
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N1709c47548554f25bcf8033115ae6c4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Chemokines, CC
84 rdf:type schema:DefinedTerm
85 N1a587f56f0c142ea9178476e5fa3d932 rdf:first sg:person.01216365616.30
86 rdf:rest N31d0d6bc235d4f72bd5a42c3117cc9c9
87 N3074eac02b664667be5c019444bb0a29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Phagocytosis
89 rdf:type schema:DefinedTerm
90 N31d0d6bc235d4f72bd5a42c3117cc9c9 rdf:first sg:person.01041700765.08
91 rdf:rest N43f24c4adc7c4da58c778bef336127a2
92 N3633a60b0294461e8ba85cf07d66ac81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Male
94 rdf:type schema:DefinedTerm
95 N39dd348c56734a6e9fdfbc761409b33c rdf:first sg:person.01326217527.44
96 rdf:rest Ncb3099193e8c4d1caa3ade361eafdc47
97 N3e9cbb8d5beb4e54871a25d547a0271f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Cell Differentiation
99 rdf:type schema:DefinedTerm
100 N43f24c4adc7c4da58c778bef336127a2 rdf:first sg:person.01110014165.27
101 rdf:rest Nfc3865a2162142bab8ad589d01510987
102 N47b0eea4d0a742a398013a42d44b3b0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Rats, Wistar
104 rdf:type schema:DefinedTerm
105 N53844e73d0be4ea2a17578a35230bc60 schema:name nlm_unique_id
106 schema:value 9430794
107 rdf:type schema:PropertyValue
108 N6007dcd4a8ae47c7b4c2024c16b132ff rdf:first sg:person.01053170647.97
109 rdf:rest rdf:nil
110 N61c4312ff36e4cd6812efcae41abd57d schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 N660d5fa014f545e2849bc0840ea9acce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Dendritic Cells
114 rdf:type schema:DefinedTerm
115 N6d887642324d45888776a0c219b92ff7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Antigen Presentation
117 rdf:type schema:DefinedTerm
118 N6e0c7df6bcd64701b9d25351860c48b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Intestinal Mucosa
120 rdf:type schema:DefinedTerm
121 N8404016e3ccd4df086a2385136e9dd53 schema:volumeNumber 41
122 rdf:type schema:PublicationVolume
123 N8ade4be787f94f3e991ae5380122c6a6 schema:issueNumber 3
124 rdf:type schema:PublicationIssue
125 N92899148d3de4283a1ef18b7ec1ff5e4 schema:name readcube_id
126 schema:value 120d1412674277cf5bc36f9484ac9be40a578e6443a258d84d9cb18870be8713
127 rdf:type schema:PropertyValue
128 N9b419d5fed6f4a1c9f95666696467eca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Histocompatibility Antigens Class II
130 rdf:type schema:DefinedTerm
131 N9eba4b6fcd0141e3864fda2b00fc0400 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Fatty Acids
133 rdf:type schema:DefinedTerm
134 Nb340d60e419b42248d0d2c58533de2da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Cell Separation
136 rdf:type schema:DefinedTerm
137 Nc42ddfc6502d41a59806f4569ca6cb0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Chemotaxis
139 rdf:type schema:DefinedTerm
140 Ncb3099193e8c4d1caa3ade361eafdc47 rdf:first sg:person.01013636601.61
141 rdf:rest Ne531f07b31a54232ab4c6f512e33bd54
142 Ncf7eeebd58df44a8bc63e52d129d3e61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Rats
144 rdf:type schema:DefinedTerm
145 Nd6d745f1a1de46fbae6e11e5fabb91d6 rdf:first sg:person.01111641416.14
146 rdf:rest N39dd348c56734a6e9fdfbc761409b33c
147 Ne209b79d86454cf58b7890cd3114cb73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Animals
149 rdf:type schema:DefinedTerm
150 Ne531f07b31a54232ab4c6f512e33bd54 rdf:first sg:person.0670627047.38
151 rdf:rest N1a587f56f0c142ea9178476e5fa3d932
152 Ned72b413c111477db836c6c59cc386c9 schema:name doi
153 schema:value 10.1007/s00535-005-1747-0
154 rdf:type schema:PropertyValue
155 Nf03ccd970fa44a34b5e004a18e1447c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Flow Cytometry
157 rdf:type schema:DefinedTerm
158 Nf21b71bf9b164a0c8d68bb25ad0621f6 schema:name dimensions_id
159 schema:value pub.1003789117
160 rdf:type schema:PropertyValue
161 Nfa5b15c135bf4eed94801961c39ef3e6 schema:name pubmed_id
162 schema:value 16699854
163 rdf:type schema:PropertyValue
164 Nfc3865a2162142bab8ad589d01510987 rdf:first sg:person.016344126032.54
165 rdf:rest N6007dcd4a8ae47c7b4c2024c16b132ff
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
170 schema:name Immunology
171 rdf:type schema:DefinedTerm
172 sg:journal.1009747 schema:issn 0944-1174
173 1435-5922
174 schema:name Journal of Gastroenterology
175 rdf:type schema:Periodical
176 sg:person.01013636601.61 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
177 schema:familyName Matsuzaki
178 schema:givenName Koji
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013636601.61
180 rdf:type schema:Person
181 sg:person.01041700765.08 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
182 schema:familyName Kawaguchi
183 schema:givenName Atsushi
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041700765.08
185 rdf:type schema:Person
186 sg:person.01053170647.97 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
187 schema:familyName Miura
188 schema:givenName Soichiro
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053170647.97
190 rdf:type schema:Person
191 sg:person.01110014165.27 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
192 schema:familyName Nagao
193 schema:givenName Shigeaki
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110014165.27
195 rdf:type schema:Person
196 sg:person.01111641416.14 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
197 schema:familyName Tsuzuki
198 schema:givenName Yoshikazu
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111641416.14
200 rdf:type schema:Person
201 sg:person.01216365616.30 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
202 schema:familyName Hokari
203 schema:givenName Ryota
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216365616.30
205 rdf:type schema:Person
206 sg:person.01326217527.44 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
207 schema:familyName Miyazaki
208 schema:givenName Jyunichi
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326217527.44
210 rdf:type schema:Person
211 sg:person.016344126032.54 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
212 schema:familyName Itoh
213 schema:givenName Kazuro
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016344126032.54
215 rdf:type schema:Person
216 sg:person.0670627047.38 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
217 schema:familyName Okada
218 schema:givenName Yoshikiyo
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670627047.38
220 rdf:type schema:Person
221 sg:pub.10.1038/86373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049106469
222 https://doi.org/10.1038/86373
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/nature01726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041439773
225 https://doi.org/10.1038/nature01726
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/ni0802-699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048481793
228 https://doi.org/10.1038/ni0802-699
229 rdf:type schema:CreativeWork
230 sg:pub.10.1111/1523-1747.ep12475701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012627250
231 https://doi.org/10.1111/1523-1747.ep12475701
232 rdf:type schema:CreativeWork
233 sg:pub.10.1111/j.0022-202x.2004.23229.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047698383
234 https://doi.org/10.1111/j.0022-202x.2004.23229.x
235 rdf:type schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1074548961 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1077764007 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1079504286 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1081631680 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1082528778 schema:CreativeWork
241 https://doi.org/10.1002/(sici)1099-0844(200001/03)18:1<47::aid-cbf848>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042521593
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/1521-4141(200203)32:3<742::aid-immu742>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043966493
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/eji.1830180107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001640516
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/jlb.53.4.420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082650107
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/jlb.62.6.771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083185193
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/jlb.64.2.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083309208
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0016-5085(00)82361-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011197747
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0092-8674(00)80059-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030055641
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1053/gast.1997.v112.pm9041243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010956157
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1074/jbc.272.27.16709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036296905
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1078/0171-2985-00094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042494440
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1084/jem.191.8.1381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028849956
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1084/jem.192.11.1545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038430820
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1084/jem.193.7.839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033089077
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1084/jem.20031244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010293587
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/ajcn/63.5.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082880685
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1093/jn/130.11.2636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074719436
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1093/jn/131.11.2943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074950364
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1096/fasebj.3.9.2501132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078940298
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1097/00004836-199700001-00032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060191218
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1097/00054725-200502000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007683872
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1098/rstb.2000.0779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029045371
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1182/blood.v99.8.2869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050211608
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1189/jlb.0603250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021551150
288 rdf:type schema:CreativeWork
289 https://doi.org/10.4049/jimmunol.165.6.3301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074694865
290 rdf:type schema:CreativeWork
291 https://doi.org/10.4049/jimmunol.168.5.2255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075002192
292 rdf:type schema:CreativeWork
293 https://doi.org/10.4049/jimmunol.168.9.4446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075039338
294 rdf:type schema:CreativeWork
295 https://doi.org/10.4049/jimmunol.169.3.1326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075090486
296 rdf:type schema:CreativeWork
297 https://www.grid.ac/institutes/grid.416614.0 schema:alternateName National Defense Medical College
298 schema:name Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...