Recent clinical features of Wilson’s disease with hepatic presentation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-12

AUTHORS

Teru Kumagi, Norio Horiike, Kojiro Michitaka, Aki Hasebe, Keiko Kawai, Yoshio Tokumoto, Seiji Nakanishi, Shinya Furukawa, Yoichi Hiasa, Hidetaka Matsui, Kiyotaka Kurose, Bunzo Matsuura, Morikazu Onji

ABSTRACT

BackgroundWe carried out this study to evaluate recent clinical features of Wilson’s disease (WD) with hepatic presentation, especially in terms of age, degree of liver injury, and association with hepatocellular carcinoma (HCC).MethodsSixteen patients with hepatic manifestations were diagnosed with WD in the period 1976–2003. We divided this period into two periods, “past” and “recent”. The diagnosis was based on the presence of Kayser-Fleisher rings, low serum copper levels, low serum ceruloplasmin levels, increased urinary copper concentrations before or after D-penicillamine challenge, and increased hepatic copper concentrations. This retrospective study was done at Ehime University Hospital.ResultsFour patients, including a pair of siblings, had a family history of WD. Four patients had parental consanguinity. There were 6 patients aged over 40 years in the recent period, whereas no patients in the past period were over 40. Four patients had neurological manifestations. Ten patients had liver cirrhosis and 5 had chronic hepatitis. Two had fatty liver without obesity. All patients in the past period had liver cirrhosis. Three patients with liver cirrhosis were found to have HCC during the follow up. All patients were treated with either D-penicillamine or trientine chloride, or both. However, four patients had to discontinue these agents due to the side effects.ConclusionsRecently, the number of patients diagnosed with WD has been increasing, not only in terms of those with classical-type WD but also in terms of elderly patients or patients with non-cirrhotic liver injury such as fatty liver and chronic hepatitis. The various clinical features of WD should be recognized and particular attention should focus on HCC as a complication. More... »

PAGES

1165-1169

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-004-1466-y

DOI

http://dx.doi.org/10.1007/s00535-004-1466-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049928674

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15622480


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatolenticular Degeneration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumagi", 
        "givenName": "Teru", 
        "id": "sg:person.01066054314.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066054314.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horiike", 
        "givenName": "Norio", 
        "id": "sg:person.0732724765.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732724765.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michitaka", 
        "givenName": "Kojiro", 
        "id": "sg:person.0655540352.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655540352.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasebe", 
        "givenName": "Aki", 
        "id": "sg:person.01144230645.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144230645.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawai", 
        "givenName": "Keiko", 
        "id": "sg:person.0775627710.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775627710.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tokumoto", 
        "givenName": "Yoshio", 
        "id": "sg:person.01042071567.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042071567.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakanishi", 
        "givenName": "Seiji", 
        "id": "sg:person.01363402632.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363402632.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furukawa", 
        "givenName": "Shinya", 
        "id": "sg:person.0644725370.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644725370.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiasa", 
        "givenName": "Yoichi", 
        "id": "sg:person.01333031252.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333031252.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsui", 
        "givenName": "Hidetaka", 
        "id": "sg:person.01037253336.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037253336.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurose", 
        "givenName": "Kiyotaka", 
        "id": "sg:person.0711767204.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711767204.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuura", 
        "givenName": "Bunzo", 
        "id": "sg:person.0607425152.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607425152.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onji", 
        "givenName": "Morikazu", 
        "id": "sg:person.0723653552.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723653552.71"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2004-12", 
    "datePublishedReg": "2004-12-01", 
    "description": "BackgroundWe carried out this study to evaluate recent clinical features of Wilson\u2019s disease (WD) with hepatic presentation, especially in terms of age, degree of liver injury, and association with hepatocellular carcinoma (HCC).MethodsSixteen patients with hepatic manifestations were diagnosed with WD in the period 1976\u20132003. We divided this period into two periods, \u201cpast\u201d and \u201crecent\u201d. The diagnosis was based on the presence of Kayser-Fleisher rings, low serum copper levels, low serum ceruloplasmin levels, increased urinary copper concentrations before or after D-penicillamine challenge, and increased hepatic copper concentrations. This retrospective study was done at Ehime University Hospital.ResultsFour patients, including a pair of siblings, had a family history of WD. Four patients had parental consanguinity. There were 6 patients aged over 40 years in the recent period, whereas no patients in the past period were over 40. Four patients had neurological manifestations. Ten patients had liver cirrhosis and 5 had chronic hepatitis. Two had fatty liver without obesity. All patients in the past period had liver cirrhosis. Three patients with liver cirrhosis were found to have HCC during the follow up. All patients were treated with either D-penicillamine or trientine chloride, or both. However, four patients had to discontinue these agents due to the side effects.ConclusionsRecently, the number of patients diagnosed with WD has been increasing, not only in terms of those with classical-type WD but also in terms of elderly patients or patients with non-cirrhotic liver injury such as fatty liver and chronic hepatitis. The various clinical features of WD should be recognized and particular attention should focus on HCC as a complication.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00535-004-1466-y", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1009747", 
        "issn": [
          "0944-1174", 
          "1435-5922"
        ], 
        "name": "Journal of Gastroenterology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "keywords": [
      "recent clinical features", 
      "hepatocellular carcinoma", 
      "liver cirrhosis", 
      "clinical features", 
      "Wilson's disease", 
      "chronic hepatitis", 
      "liver injury", 
      "fatty liver", 
      "hepatic presentation", 
      "low serum ceruloplasmin levels", 
      "low serum copper levels", 
      "urinary copper concentration", 
      "D-penicillamine challenge", 
      "Ehime University Hospital", 
      "number of patients", 
      "serum ceruloplasmin levels", 
      "Kayser-Fleisher rings", 
      "serum copper levels", 
      "terms of age", 
      "hepatic copper concentration", 
      "ResultsFour patients", 
      "hepatic manifestation", 
      "elderly patients", 
      "MethodsSixteen patients", 
      "neurological manifestations", 
      "retrospective study", 
      "University Hospital", 
      "family history", 
      "ceruloplasmin levels", 
      "pairs of siblings", 
      "patients", 
      "side effects", 
      "parental consanguinity", 
      "cirrhosis", 
      "D-penicillamine", 
      "disease", 
      "hepatitis", 
      "injury", 
      "liver", 
      "copper levels", 
      "manifestations", 
      "presentation", 
      "period", 
      "obesity", 
      "complications", 
      "carcinoma", 
      "BackgroundWe", 
      "hospital", 
      "follow", 
      "diagnosis", 
      "copper concentration", 
      "age", 
      "consanguinity", 
      "levels", 
      "study", 
      "association", 
      "siblings", 
      "concentration", 
      "years", 
      "agents", 
      "history", 
      "features", 
      "effect", 
      "presence", 
      "number", 
      "particular attention", 
      "recent period", 
      "degree", 
      "challenges", 
      "terms", 
      "attention", 
      "chloride", 
      "pairs", 
      "past", 
      "ring", 
      "past period"
    ], 
    "name": "Recent clinical features of Wilson\u2019s disease with hepatic presentation", 
    "pagination": "1165-1169", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049928674"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00535-004-1466-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15622480"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00535-004-1466-y", 
      "https://app.dimensions.ai/details/publication/pub.1049928674"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_388.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00535-004-1466-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00535-004-1466-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00535-004-1466-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00535-004-1466-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00535-004-1466-y'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      20 PREDICATES      115 URIs      107 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00535-004-1466-y schema:about N072c758a31804b83aa2ab19013b2145b
2 N20ccc8b395c1459b89343eb6f3d2c602
3 N32dd3d32d0254a8ca279a4b08063fbc6
4 N5997d129b4fb48e395431d004a78fa95
5 N67487fdab3ec45d381181eb83af7e329
6 N69560279f7c14fa6a922469fd6223064
7 N75ced24510954796a96111a7f9fe6074
8 N7b94fe5738914f58a2079c3282f18700
9 N903f39febf244ad5be47d718955bbecc
10 Na0840fe8dea148d29349f82782e6d0ad
11 Nb2b4ed7b75904a0294ec94e5788649b9
12 Nd9efacb38fea489ebffc51917052565e
13 Ne9417097933d4b7b81f4b814de303cb1
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author N4716a6ad448440af9645b3370fe85983
17 schema:datePublished 2004-12
18 schema:datePublishedReg 2004-12-01
19 schema:description BackgroundWe carried out this study to evaluate recent clinical features of Wilson’s disease (WD) with hepatic presentation, especially in terms of age, degree of liver injury, and association with hepatocellular carcinoma (HCC).MethodsSixteen patients with hepatic manifestations were diagnosed with WD in the period 1976–2003. We divided this period into two periods, “past” and “recent”. The diagnosis was based on the presence of Kayser-Fleisher rings, low serum copper levels, low serum ceruloplasmin levels, increased urinary copper concentrations before or after D-penicillamine challenge, and increased hepatic copper concentrations. This retrospective study was done at Ehime University Hospital.ResultsFour patients, including a pair of siblings, had a family history of WD. Four patients had parental consanguinity. There were 6 patients aged over 40 years in the recent period, whereas no patients in the past period were over 40. Four patients had neurological manifestations. Ten patients had liver cirrhosis and 5 had chronic hepatitis. Two had fatty liver without obesity. All patients in the past period had liver cirrhosis. Three patients with liver cirrhosis were found to have HCC during the follow up. All patients were treated with either D-penicillamine or trientine chloride, or both. However, four patients had to discontinue these agents due to the side effects.ConclusionsRecently, the number of patients diagnosed with WD has been increasing, not only in terms of those with classical-type WD but also in terms of elderly patients or patients with non-cirrhotic liver injury such as fatty liver and chronic hepatitis. The various clinical features of WD should be recognized and particular attention should focus on HCC as a complication.
20 schema:genre article
21 schema:isAccessibleForFree false
22 schema:isPartOf Na134b108531b40a3a58d06accbcdd119
23 Nf38c420c1b25448bb318968988228860
24 sg:journal.1009747
25 schema:keywords BackgroundWe
26 D-penicillamine
27 D-penicillamine challenge
28 Ehime University Hospital
29 Kayser-Fleisher rings
30 MethodsSixteen patients
31 ResultsFour patients
32 University Hospital
33 Wilson's disease
34 age
35 agents
36 association
37 attention
38 carcinoma
39 ceruloplasmin levels
40 challenges
41 chloride
42 chronic hepatitis
43 cirrhosis
44 clinical features
45 complications
46 concentration
47 consanguinity
48 copper concentration
49 copper levels
50 degree
51 diagnosis
52 disease
53 effect
54 elderly patients
55 family history
56 fatty liver
57 features
58 follow
59 hepatic copper concentration
60 hepatic manifestation
61 hepatic presentation
62 hepatitis
63 hepatocellular carcinoma
64 history
65 hospital
66 injury
67 levels
68 liver
69 liver cirrhosis
70 liver injury
71 low serum ceruloplasmin levels
72 low serum copper levels
73 manifestations
74 neurological manifestations
75 number
76 number of patients
77 obesity
78 pairs
79 pairs of siblings
80 parental consanguinity
81 particular attention
82 past
83 past period
84 patients
85 period
86 presence
87 presentation
88 recent clinical features
89 recent period
90 retrospective study
91 ring
92 serum ceruloplasmin levels
93 serum copper levels
94 siblings
95 side effects
96 study
97 terms
98 terms of age
99 urinary copper concentration
100 years
101 schema:name Recent clinical features of Wilson’s disease with hepatic presentation
102 schema:pagination 1165-1169
103 schema:productId N1c52456bb21040209c034bef32503d70
104 Na0fe80194e7241db9f87546e547056b1
105 Nf858b3ae5d294ac49bafe6a6b3a63b33
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049928674
107 https://doi.org/10.1007/s00535-004-1466-y
108 schema:sdDatePublished 2022-12-01T06:24
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N3138159834154dbbb51bbae47b4b6bfd
111 schema:url https://doi.org/10.1007/s00535-004-1466-y
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N072c758a31804b83aa2ab19013b2145b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Female
117 rdf:type schema:DefinedTerm
118 N0d07e93919104bf4822bd00e8e3bb591 rdf:first sg:person.0732724765.18
119 rdf:rest Nb7555cfc475444cf8b68365ef59a21a9
120 N1c52456bb21040209c034bef32503d70 schema:name doi
121 schema:value 10.1007/s00535-004-1466-y
122 rdf:type schema:PropertyValue
123 N209b24771e1241c9b16940821d8ff86d rdf:first sg:person.0644725370.29
124 rdf:rest N5751a82bdc74480b9109a854df83e58e
125 N20cba7dcd48141b79e462645edb1e5d9 rdf:first sg:person.0723653552.71
126 rdf:rest rdf:nil
127 N20ccc8b395c1459b89343eb6f3d2c602 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Child
129 rdf:type schema:DefinedTerm
130 N26db2585076941ff90618ba3c9454814 rdf:first sg:person.0775627710.41
131 rdf:rest N7149b9739edb4f41bc63190842af9702
132 N3138159834154dbbb51bbae47b4b6bfd schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N32dd3d32d0254a8ca279a4b08063fbc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N44ab4ed4184242238e70d464c5798ab0 rdf:first sg:person.01144230645.98
138 rdf:rest N26db2585076941ff90618ba3c9454814
139 N4716a6ad448440af9645b3370fe85983 rdf:first sg:person.01066054314.49
140 rdf:rest N0d07e93919104bf4822bd00e8e3bb591
141 N5751a82bdc74480b9109a854df83e58e rdf:first sg:person.01333031252.69
142 rdf:rest N97ba9c2e72cf4aa09d34c39b8027cf6b
143 N5997d129b4fb48e395431d004a78fa95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Middle Aged
145 rdf:type schema:DefinedTerm
146 N67487fdab3ec45d381181eb83af7e329 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Adult
148 rdf:type schema:DefinedTerm
149 N69560279f7c14fa6a922469fd6223064 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Male
151 rdf:type schema:DefinedTerm
152 N7149b9739edb4f41bc63190842af9702 rdf:first sg:person.01042071567.97
153 rdf:rest Nd5c6105e0c40467194a6c1fdc3d9dbd6
154 N75ced24510954796a96111a7f9fe6074 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Carcinoma, Hepatocellular
156 rdf:type schema:DefinedTerm
157 N7b94fe5738914f58a2079c3282f18700 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Adolescent
159 rdf:type schema:DefinedTerm
160 N7fab707f343e4e9481324e8e88290814 rdf:first sg:person.0607425152.67
161 rdf:rest N20cba7dcd48141b79e462645edb1e5d9
162 N903f39febf244ad5be47d718955bbecc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Aged
164 rdf:type schema:DefinedTerm
165 N97ba9c2e72cf4aa09d34c39b8027cf6b rdf:first sg:person.01037253336.79
166 rdf:rest Nbe26a22e656940629694a6e9f9ba0221
167 Na0840fe8dea148d29349f82782e6d0ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Retrospective Studies
169 rdf:type schema:DefinedTerm
170 Na0fe80194e7241db9f87546e547056b1 schema:name pubmed_id
171 schema:value 15622480
172 rdf:type schema:PropertyValue
173 Na134b108531b40a3a58d06accbcdd119 schema:volumeNumber 39
174 rdf:type schema:PublicationVolume
175 Nb2b4ed7b75904a0294ec94e5788649b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Hepatolenticular Degeneration
177 rdf:type schema:DefinedTerm
178 Nb7555cfc475444cf8b68365ef59a21a9 rdf:first sg:person.0655540352.56
179 rdf:rest N44ab4ed4184242238e70d464c5798ab0
180 Nbe26a22e656940629694a6e9f9ba0221 rdf:first sg:person.0711767204.50
181 rdf:rest N7fab707f343e4e9481324e8e88290814
182 Nd5c6105e0c40467194a6c1fdc3d9dbd6 rdf:first sg:person.01363402632.78
183 rdf:rest N209b24771e1241c9b16940821d8ff86d
184 Nd9efacb38fea489ebffc51917052565e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Liver Neoplasms
186 rdf:type schema:DefinedTerm
187 Ne9417097933d4b7b81f4b814de303cb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Liver Diseases
189 rdf:type schema:DefinedTerm
190 Nf38c420c1b25448bb318968988228860 schema:issueNumber 12
191 rdf:type schema:PublicationIssue
192 Nf858b3ae5d294ac49bafe6a6b3a63b33 schema:name dimensions_id
193 schema:value pub.1049928674
194 rdf:type schema:PropertyValue
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
199 schema:name Clinical Sciences
200 rdf:type schema:DefinedTerm
201 sg:journal.1009747 schema:issn 0944-1174
202 1435-5922
203 schema:name Journal of Gastroenterology
204 schema:publisher Springer Nature
205 rdf:type schema:Periodical
206 sg:person.01037253336.79 schema:affiliation grid-institutes:grid.255464.4
207 schema:familyName Matsui
208 schema:givenName Hidetaka
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037253336.79
210 rdf:type schema:Person
211 sg:person.01042071567.97 schema:affiliation grid-institutes:grid.255464.4
212 schema:familyName Tokumoto
213 schema:givenName Yoshio
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042071567.97
215 rdf:type schema:Person
216 sg:person.01066054314.49 schema:affiliation grid-institutes:grid.255464.4
217 schema:familyName Kumagi
218 schema:givenName Teru
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066054314.49
220 rdf:type schema:Person
221 sg:person.01144230645.98 schema:affiliation grid-institutes:grid.255464.4
222 schema:familyName Hasebe
223 schema:givenName Aki
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144230645.98
225 rdf:type schema:Person
226 sg:person.01333031252.69 schema:affiliation grid-institutes:grid.255464.4
227 schema:familyName Hiasa
228 schema:givenName Yoichi
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333031252.69
230 rdf:type schema:Person
231 sg:person.01363402632.78 schema:affiliation grid-institutes:grid.255464.4
232 schema:familyName Nakanishi
233 schema:givenName Seiji
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363402632.78
235 rdf:type schema:Person
236 sg:person.0607425152.67 schema:affiliation grid-institutes:grid.255464.4
237 schema:familyName Matsuura
238 schema:givenName Bunzo
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607425152.67
240 rdf:type schema:Person
241 sg:person.0644725370.29 schema:affiliation grid-institutes:grid.255464.4
242 schema:familyName Furukawa
243 schema:givenName Shinya
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644725370.29
245 rdf:type schema:Person
246 sg:person.0655540352.56 schema:affiliation grid-institutes:grid.255464.4
247 schema:familyName Michitaka
248 schema:givenName Kojiro
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655540352.56
250 rdf:type schema:Person
251 sg:person.0711767204.50 schema:affiliation grid-institutes:grid.255464.4
252 schema:familyName Kurose
253 schema:givenName Kiyotaka
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711767204.50
255 rdf:type schema:Person
256 sg:person.0723653552.71 schema:affiliation grid-institutes:grid.255464.4
257 schema:familyName Onji
258 schema:givenName Morikazu
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723653552.71
260 rdf:type schema:Person
261 sg:person.0732724765.18 schema:affiliation grid-institutes:grid.255464.4
262 schema:familyName Horiike
263 schema:givenName Norio
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732724765.18
265 rdf:type schema:Person
266 sg:person.0775627710.41 schema:affiliation grid-institutes:grid.255464.4
267 schema:familyName Kawai
268 schema:givenName Keiko
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775627710.41
270 rdf:type schema:Person
271 grid-institutes:grid.255464.4 schema:alternateName Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan
272 schema:name Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu, Japan
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...