Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06

AUTHORS

Kazuaki Kitajima, Takahiro Fujimori, Shigehiko Fujii, Jun Takeda, Yasuo Ohkura, Hitoshi Kawamata, Toshihide Kumamoto, Shingo Ishiguro, Yo Kato, Tadakazu Shimoda, Akinori Iwashita, Yoichi Ajioka, Hidenobu Watanabe, Toshiaki Watanabe, Tetsuichiro Muto, Ko Nagasako

ABSTRACT

BackgroundDepth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the correlations between lymph node metastasis and SM depth in SICC.MethodsSM depth was measured for 865 SICCs that were surgically resected at six institutions throughout Japan. For pedunculated SICC, the level 2 line according to Haggitt’s classification was used as baseline and the SM depth was measured from this baseline to the deepest portion in the submucosa. When the deepest portion of invasion was limited to above the baseline, the case was defined as a head invasion. For nonpedunculated SICC, when the muscularis mucosae could be identified, the muscularis mucosae was used as baseline and the vertical distance from this line to the deepest portion of invasion represented SM depth. When the muscularis mucosae could not be identified due to carcinomatous invasion, the superficial aspect of the SICC was used as baseline, and the vertical distance from this line to the deepest portion was determined.ResultsFor pedunculated SICC, rate of lymph node metastasis was 0% in head invasion cases and stalk invasion cases with SM depth <3000 µm if lymphatic invasion was negative. For nonpedunculated SICC, rate of lymph node metastasis was also 0% if SM depth was <1000 µm.ConclusionsThese results clarified rates of lymph node metastasis in SICC according to SM depth, and may contribute to defining therapeutic strategies for SICC. More... »

PAGES

534-543

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-004-1339-4

DOI

http://dx.doi.org/10.1007/s00535-004-1339-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020821843

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15235870


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22 schema:description BackgroundDepth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the correlations between lymph node metastasis and SM depth in SICC.MethodsSM depth was measured for 865 SICCs that were surgically resected at six institutions throughout Japan. For pedunculated SICC, the level 2 line according to Haggitt’s classification was used as baseline and the SM depth was measured from this baseline to the deepest portion in the submucosa. When the deepest portion of invasion was limited to above the baseline, the case was defined as a head invasion. For nonpedunculated SICC, when the muscularis mucosae could be identified, the muscularis mucosae was used as baseline and the vertical distance from this line to the deepest portion of invasion represented SM depth. When the muscularis mucosae could not be identified due to carcinomatous invasion, the superficial aspect of the SICC was used as baseline, and the vertical distance from this line to the deepest portion was determined.ResultsFor pedunculated SICC, rate of lymph node metastasis was 0% in head invasion cases and stalk invasion cases with SM depth <3000 µm if lymphatic invasion was negative. For nonpedunculated SICC, rate of lymph node metastasis was also 0% if SM depth was <1000 µm.ConclusionsThese results clarified rates of lymph node metastasis in SICC according to SM depth, and may contribute to defining therapeutic strategies for SICC.
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29 schema:keywords ConclusionsThese results
30 Haggitt's classification
31 Japan
32 Japanese collaborative study
33 SM depth
34 aim
35 aspects
36 baseline
37 carcinoma
38 carcinomatous invasion
39 cases
40 classification
41 collaborative study
42 colorectal carcinoma
43 correlation
44 deep portion
45 depth
46 distance
47 factors
48 head invasion
49 important predictive factor
50 institutions
51 invasion
52 invasion cases
53 invasive colorectal carcinoma
54 lines
55 lymph
56 lymph node metastasis
57 lymphatic invasion
58 metastasis
59 mucosa
60 muscularis mucosae
61 nationwide report
62 node metastasis
63 portion
64 predictive factors
65 rate
66 rate of lymph
67 relationship
68 report
69 results
70 strategies
71 study
72 submucosa
73 submucosal invasion
74 submucosal invasive colorectal carcinoma
75 superficial aspect
76 therapeutic strategies
77 vertical distance
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