p16 and p53 gene alterations and accumulations in the malignant evolution of intraductal papillary-mucinous tumors of the pancreas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Keita Wada

ABSTRACT

.Abstract.Background/Purpose: In general, intraductal papillary-mucinous tumors of the pancreas have a favorable prognosis. However, some invasive carcinomas show a rapid progression and a poor prognosis, such as invasive ductal carcinomas of the pancreas. The aim of this study was to clarify the genetic backgrounds underlying the evolution necessary for these tumors to become invasive carcinomas.Methods: Twenty-three patients with intraductal papillary-mucinous tumors, including 9 adenomas, 5 borderline tumors, 3 noninvasive carcinomas, and 6 invasive carcinomas, along with 24 patients with invasive ductal carcinomas were studied. After microdissection, K-ras mutation and loss of heterozygosity (LOH) of the p16 and p53 genes were investigated.Results: In the intraductal papillary-mucinous tumors, K-ras mutations were frequently seen, without a relationship to histological grade. LOH of the p16 gene was observed increasingly with increasing degrees of histological atypia. LOH of the p53 gene was seen only in invasive carcinomas. The frequency of each genetic alteration in invasive carcinomas was the same as that in invasive ductal carcinomas. The accumulation of genetic alterations was as common in invasive carcinomas, as they were in invasive ductal carcinomas.Conclusions: The p16 and p53 gene alterations and accumulations observed are crucial events during the carcinogenesis and malignant progression of intraductal papillary-mucinous tumors of the pancreas. More... »

PAGES

76-85

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s005340200007

DOI

http://dx.doi.org/10.1007/s005340200007

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021204630

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12021900


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma, Mucinous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Papillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p16", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, ras", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wada", 
        "givenName": "Keita", 
        "id": "sg:person.01162577627.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162577627.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02786119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013550063", 
          "https://doi.org/10.1007/bf02786119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002689900485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030987306", 
          "https://doi.org/10.1007/s002689900485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2000.01764.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000002314", 
          "https://doi.org/10.1111/j.1572-0241.2000.01764.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0995-902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033853859", 
          "https://doi.org/10.1038/nm0995-902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00189573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044745628", 
          "https://doi.org/10.1007/bf00189573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0994-27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046920232", 
          "https://doi.org/10.1038/ng0994-27"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-02", 
    "datePublishedReg": "2002-02-01", 
    "description": "Abstract.Abstract.Background/Purpose: In general, intraductal papillary-mucinous tumors of the pancreas have a favorable prognosis. However, some invasive carcinomas show a rapid progression and a poor prognosis, such as invasive ductal carcinomas of the pancreas. The aim of this study was to clarify the genetic backgrounds underlying the evolution necessary for these tumors to become invasive carcinomas.Methods: Twenty-three patients with intraductal papillary-mucinous tumors, including 9 adenomas, 5 borderline tumors, 3 noninvasive carcinomas, and 6 invasive carcinomas, along with 24 patients with invasive ductal carcinomas were studied. After microdissection, K-ras mutation and loss of heterozygosity (LOH) of the p16 and p53 genes were investigated.Results: In the intraductal papillary-mucinous tumors, K-ras mutations were frequently seen, without a relationship to histological grade. LOH of the p16 gene was observed increasingly with increasing degrees of histological atypia. LOH of the p53 gene was seen only in invasive carcinomas. The frequency of each genetic alteration in invasive carcinomas was the same as that in invasive ductal carcinomas. The accumulation of genetic alterations was as common in invasive carcinomas, as they were in invasive ductal carcinomas.Conclusions: The p16 and p53 gene alterations and accumulations observed are crucial events during the carcinogenesis and malignant progression of intraductal papillary-mucinous tumors of the pancreas.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s005340200007", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1043285", 
        "issn": [
          "1868-6974", 
          "1868-6982"
        ], 
        "name": "Journal of Hepato-Biliary-Pancreatic Sciences", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "intraductal papillary-mucinous tumors", 
      "invasive ductal carcinoma", 
      "invasive carcinoma", 
      "ductal carcinoma", 
      "loss of heterozygosity", 
      "p53 gene alterations", 
      "ras mutations", 
      "gene alterations", 
      "genetic alterations", 
      "p53 gene", 
      "borderline tumors", 
      "favorable prognosis", 
      "poor prognosis", 
      "histological grade", 
      "rapid progression", 
      "noninvasive carcinoma", 
      "histological atypia", 
      "malignant evolution", 
      "carcinoma", 
      "tumors", 
      "malignant progression", 
      "pancreas", 
      "prognosis", 
      "patients", 
      "p16", 
      "alterations", 
      "progression", 
      "genetic background", 
      "p16 gene", 
      "crucial event", 
      "atypia", 
      "adenomas", 
      "carcinogenesis", 
      "mutations", 
      "genes", 
      "accumulation", 
      "grade", 
      "microdissection", 
      "aim", 
      "study", 
      "background", 
      "events", 
      "loss", 
      "heterozygosity", 
      "frequency", 
      "relationship", 
      "degree", 
      "evolution", 
      "papillary-mucinous tumors"
    ], 
    "name": "p16 and p53 gene alterations and accumulations in the malignant evolution of intraductal papillary-mucinous tumors of the pancreas", 
    "pagination": "76-85", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021204630"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s005340200007"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12021900"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s005340200007", 
      "https://app.dimensions.ai/details/publication/pub.1021204630"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_362.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s005340200007"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s005340200007'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s005340200007'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s005340200007'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s005340200007'


 

This table displays all metadata directly associated to this object as RDF triples.

211 TRIPLES      22 PREDICATES      101 URIs      87 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s005340200007 schema:about N0c414f093b404997a39711f086778b4d
2 N171690913ac3465cac5924e528fa179f
3 N1de97aefc55041678abe1a2ca4c01712
4 N3a4d22386ca24645ab153dfabee8094f
5 N5c3bf8f6b67948948e1cff9b7a0221ed
6 N6554cd112c254c4b9979056ad1c0ad4d
7 N6a2759957a5440a29927221af24f2ffe
8 N6e057e5ef60c4021905525e8d00f0abf
9 N9329a46ca40d484f8784f156f15d8d7c
10 N9697b1871bef4e6e9dee9edcfe3187ef
11 N9dd17065f9b04e0894057d995e32a022
12 Nb8b5744cadbf4ed3b039a17e5df538e9
13 Nc7dd31c54ceb4d46838c789653b8a727
14 Ncee8f19bb8a343188a600dfa5b5c33e7
15 Nd0a24f7559bf4e96bf04596eda04425e
16 Neb867ef45afa4d41a1d0636a29c8ca5c
17 Nf502f4666b854e0eae13eb61025752bf
18 Nf8f4128e9d9246e497275915da030508
19 Nf97256dcd75f40ddabc03fe3718f7b5e
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author Na5de77acfa374996aae4eb9ec0ba9436
23 schema:citation sg:pub.10.1007/bf00189573
24 sg:pub.10.1007/bf02786119
25 sg:pub.10.1007/s002689900485
26 sg:pub.10.1038/ng0994-27
27 sg:pub.10.1038/nm0995-902
28 sg:pub.10.1111/j.1572-0241.2000.01764.x
29 schema:datePublished 2002-02
30 schema:datePublishedReg 2002-02-01
31 schema:description Abstract.Abstract.Background/Purpose: In general, intraductal papillary-mucinous tumors of the pancreas have a favorable prognosis. However, some invasive carcinomas show a rapid progression and a poor prognosis, such as invasive ductal carcinomas of the pancreas. The aim of this study was to clarify the genetic backgrounds underlying the evolution necessary for these tumors to become invasive carcinomas.Methods: Twenty-three patients with intraductal papillary-mucinous tumors, including 9 adenomas, 5 borderline tumors, 3 noninvasive carcinomas, and 6 invasive carcinomas, along with 24 patients with invasive ductal carcinomas were studied. After microdissection, K-ras mutation and loss of heterozygosity (LOH) of the p16 and p53 genes were investigated.Results: In the intraductal papillary-mucinous tumors, K-ras mutations were frequently seen, without a relationship to histological grade. LOH of the p16 gene was observed increasingly with increasing degrees of histological atypia. LOH of the p53 gene was seen only in invasive carcinomas. The frequency of each genetic alteration in invasive carcinomas was the same as that in invasive ductal carcinomas. The accumulation of genetic alterations was as common in invasive carcinomas, as they were in invasive ductal carcinomas.Conclusions: The p16 and p53 gene alterations and accumulations observed are crucial events during the carcinogenesis and malignant progression of intraductal papillary-mucinous tumors of the pancreas.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N950dfd2ef58d4df6b97c90fd44c469ce
36 Ndd226ddb59cf4cad89b788b954822c79
37 sg:journal.1043285
38 schema:keywords accumulation
39 adenomas
40 aim
41 alterations
42 atypia
43 background
44 borderline tumors
45 carcinogenesis
46 carcinoma
47 crucial event
48 degree
49 ductal carcinoma
50 events
51 evolution
52 favorable prognosis
53 frequency
54 gene alterations
55 genes
56 genetic alterations
57 genetic background
58 grade
59 heterozygosity
60 histological atypia
61 histological grade
62 intraductal papillary-mucinous tumors
63 invasive carcinoma
64 invasive ductal carcinoma
65 loss
66 loss of heterozygosity
67 malignant evolution
68 malignant progression
69 microdissection
70 mutations
71 noninvasive carcinoma
72 p16
73 p16 gene
74 p53 gene
75 p53 gene alterations
76 pancreas
77 papillary-mucinous tumors
78 patients
79 poor prognosis
80 prognosis
81 progression
82 rapid progression
83 ras mutations
84 relationship
85 study
86 tumors
87 schema:name p16 and p53 gene alterations and accumulations in the malignant evolution of intraductal papillary-mucinous tumors of the pancreas
88 schema:pagination 76-85
89 schema:productId N3655ccb04ef94b9aa7554c6ed566e651
90 Na580bb101d6b4625acdcbcefc64499c0
91 Ne771396aaf8a4e42bb61bbbc1c8bf3f1
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021204630
93 https://doi.org/10.1007/s005340200007
94 schema:sdDatePublished 2022-01-01T18:12
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher Neca44dadf9fc4560b18c72361a77e31e
97 schema:url https://doi.org/10.1007/s005340200007
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N0c414f093b404997a39711f086778b4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Loss of Heterozygosity
103 rdf:type schema:DefinedTerm
104 N171690913ac3465cac5924e528fa179f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Carcinoma, Pancreatic Ductal
106 rdf:type schema:DefinedTerm
107 N1de97aefc55041678abe1a2ca4c01712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aged
109 rdf:type schema:DefinedTerm
110 N3655ccb04ef94b9aa7554c6ed566e651 schema:name doi
111 schema:value 10.1007/s005340200007
112 rdf:type schema:PropertyValue
113 N3a4d22386ca24645ab153dfabee8094f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Genes, p53
115 rdf:type schema:DefinedTerm
116 N5c3bf8f6b67948948e1cff9b7a0221ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Adult
118 rdf:type schema:DefinedTerm
119 N6554cd112c254c4b9979056ad1c0ad4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Neoplasm Invasiveness
121 rdf:type schema:DefinedTerm
122 N6a2759957a5440a29927221af24f2ffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Mutation
124 rdf:type schema:DefinedTerm
125 N6e057e5ef60c4021905525e8d00f0abf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Carcinoma, Papillary
127 rdf:type schema:DefinedTerm
128 N9329a46ca40d484f8784f156f15d8d7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Survival Analysis
130 rdf:type schema:DefinedTerm
131 N950dfd2ef58d4df6b97c90fd44c469ce schema:issueNumber 1
132 rdf:type schema:PublicationIssue
133 N9697b1871bef4e6e9dee9edcfe3187ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Middle Aged
135 rdf:type schema:DefinedTerm
136 N9dd17065f9b04e0894057d995e32a022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cell Transformation, Neoplastic
138 rdf:type schema:DefinedTerm
139 Na580bb101d6b4625acdcbcefc64499c0 schema:name dimensions_id
140 schema:value pub.1021204630
141 rdf:type schema:PropertyValue
142 Na5de77acfa374996aae4eb9ec0ba9436 rdf:first sg:person.01162577627.41
143 rdf:rest rdf:nil
144 Nb8b5744cadbf4ed3b039a17e5df538e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Female
146 rdf:type schema:DefinedTerm
147 Nc7dd31c54ceb4d46838c789653b8a727 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Genes, p16
149 rdf:type schema:DefinedTerm
150 Ncee8f19bb8a343188a600dfa5b5c33e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Pancreatic Neoplasms
152 rdf:type schema:DefinedTerm
153 Nd0a24f7559bf4e96bf04596eda04425e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Aged, 80 and over
155 rdf:type schema:DefinedTerm
156 Ndd226ddb59cf4cad89b788b954822c79 schema:volumeNumber 9
157 rdf:type schema:PublicationVolume
158 Ne771396aaf8a4e42bb61bbbc1c8bf3f1 schema:name pubmed_id
159 schema:value 12021900
160 rdf:type schema:PropertyValue
161 Neb867ef45afa4d41a1d0636a29c8ca5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Male
163 rdf:type schema:DefinedTerm
164 Neca44dadf9fc4560b18c72361a77e31e schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 Nf502f4666b854e0eae13eb61025752bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Adenocarcinoma, Mucinous
168 rdf:type schema:DefinedTerm
169 Nf8f4128e9d9246e497275915da030508 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Humans
171 rdf:type schema:DefinedTerm
172 Nf97256dcd75f40ddabc03fe3718f7b5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Genes, ras
174 rdf:type schema:DefinedTerm
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
179 schema:name Oncology and Carcinogenesis
180 rdf:type schema:DefinedTerm
181 sg:journal.1043285 schema:issn 1868-6974
182 1868-6982
183 schema:name Journal of Hepato-Biliary-Pancreatic Sciences
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.01162577627.41 schema:affiliation grid-institutes:grid.264706.1
187 schema:familyName Wada
188 schema:givenName Keita
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162577627.41
190 rdf:type schema:Person
191 sg:pub.10.1007/bf00189573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044745628
192 https://doi.org/10.1007/bf00189573
193 rdf:type schema:CreativeWork
194 sg:pub.10.1007/bf02786119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013550063
195 https://doi.org/10.1007/bf02786119
196 rdf:type schema:CreativeWork
197 sg:pub.10.1007/s002689900485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030987306
198 https://doi.org/10.1007/s002689900485
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/ng0994-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046920232
201 https://doi.org/10.1038/ng0994-27
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/nm0995-902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033853859
204 https://doi.org/10.1038/nm0995-902
205 rdf:type schema:CreativeWork
206 sg:pub.10.1111/j.1572-0241.2000.01764.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000002314
207 https://doi.org/10.1111/j.1572-0241.2000.01764.x
208 rdf:type schema:CreativeWork
209 grid-institutes:grid.264706.1 schema:alternateName Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan, JP
210 schema:name Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan, JP
211 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...