Molecular prognostic markers in pancreatic cancer View Full Text


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Article Info

DATE

2002-02

AUTHORS

Paula Ghaneh, Anthony Kawesha, James D. Evans, John P. Neoptolemos

ABSTRACT

. Pancreatic cancer has a very poor prognosis and is a common cause of cancer death in the Western world. Certain genetic alterations may be important in the prognosis of pancreatic cancer. Activation mutations in the K-ras oncogene occur in around 90% of pancreatic cancers, and the overexpression of growth factors epidermal growth factor (EGF), transforming growth factor (TGF)α, TGFβs 1–3, acidic fibroblast growth factor (aFGF), basic FGF (bFGF), and growth factor receptors c-erbB-2 and -3 and TGFRβs 1–3 is common. High mutation levels of cell cycle control genes such as p53, p16, p21, SMAD4, and cyclin D1 are found, and there is abnormal expression of apoptotic genes, such as bcl-2, bcl-XL, and bax. The expression of several of these growth factors and their receptors has been found to be associated with poorly differentiated tumors of an advanced stage and decreased survival. However, the inactivation and loss of expression of p16, p53, and p21, and the expression of several apoptotic genes, such as bax and bcl-2, have not been found to be of any prognostic significance. The expression of wild type p53, however, may predict responsiveness to chemotherapy. TGFβ1 expression has been shown to be associated with longer survival in patients with pancreatic cancer. Two studies (including our own) have found bcl-XL expression to be significantly associated with poor survival. These and newer molecular markers may prove to be important in the choice of future therapies for pancreatic cancer. More... »

PAGES

1-11

References to SciGraph publications

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  • 1996-12. Ca 19-9 serum course and prognosis of pancreatic cancer in JOURNAL OF GASTROINTESTINAL CANCER
  • 1989-04. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor in NATURE
  • 1997-04. Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma in JOURNAL OF GASTROINTESTINAL CANCER
  • 1996-04. Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease in BRITISH JOURNAL OF CANCER
  • 1993-12. p21 is a universal inhibitor of cyclin kinases in NATURE
  • 1997-02. Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma in BRITISH JOURNAL OF CANCER
  • 1996-10. Clinicopathological significance of Ki-ras point mutation and p21 expression in benign and malignant exocrine tumors of the human pancreas in JOURNAL OF GASTROINTESTINAL CANCER
  • 1997-04. Progress report: A randomized multicenter European stydy comparing adjuvant radiotherapy, 6 Mo chemotherapy, and combination therapy vs No-adjuvant treatment in resectable pancreatic cancer (ESPAC-1) in JOURNAL OF GASTROINTESTINAL CANCER
  • 1993-12. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 in NATURE
  • 1995-02. Overexpression of HER2/neu oncogene in pancreatic cancer correlates with shortened survival in JOURNAL OF GASTROINTESTINAL CANCER
  • Journal

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    URI

    http://scigraph.springernature.com/pub.10.1007/s005340200000

    DOI

    http://dx.doi.org/10.1007/s005340200000

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044808174

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12021893


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