Reversal of portal flow after acute rejection in living-donor liver transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

Hiroyuki Sugimoto, Tetsuya Kaneko, Yuji Marui, Soichiro Inoue, Takahiko Seo, Tsuyoshi Hatsuno, Hisami Ando, Akimasa Nakao

ABSTRACT

. Portal hepatofugal flow is rare after liver transplantation. We experienced a case in which hepatofugal portal flow was observed in acute rejection. A 6-year-old boy with glycogen storage disease type Ia underwent living-donor liver transplantation. On postoperative day 7, portal venous peak velocity was markedly decreased without portal thrombosis and obstruction of the hepatic vein, and hepatic arterial peak velocity increased reciprocally. Based on a diagnosis of acute rejection, made on postoperative day 8, we initiated steroid pulse therapy. Despite the employment of this therapy, continuous hepatofugal portal flow was observed in the entire liver on postoperative day 8. On day 12, as the liver disorder progressed, the Doppler waveform in the portal vein changed from continuous to pulsatile hepatofugal flow. The patient died of liver failure on day 14. The histological findings of a biopsy specimen on day 9 showed centrilobular necrosis, while total hepatocellular necrosis was seen at autopsy. Hepatofugal flow after liver transplantation is considered to be an ominous sign caused by several factors, and its appearance indicates a fatal condition. More... »

PAGES

573-576

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s005340100028

DOI

http://dx.doi.org/10.1007/s005340100028

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042290078

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11956911


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