Tumor diameter and Ki-67 expression in biopsy could be diagnostic markers discriminating from adenoma and early stage cancer in patients ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02-22

AUTHORS

Kensuke Kubota, Yuji Fujita, Takamitsu Sato, Seitaro Watanabe, Kunihiro Hosono, Masato Yoneda, Hiroyuki Kirikoshi, Kantaro Hisatomi, Nobuyuki Matsuhashi, Itaru Endo, Yoshiaki Inayama, Atsushi Nakajima

ABSTRACT

BackgroundAmpullary early stage cancer (early CA) potentially harbors lymphovascular invasion; there are few data on markers that could differentiate adenoma and early CA.AimTo investigate those markers, we compared the tumor diameter and Ki-67 expression in endoscopy biopsy specimens of adenoma with those of early CA.MethodsPatients on whom endoscopic papillectomy (EP) was performed (n = 35) with histopathologically proven adenomas and with low/high grade dysplasia and early CA were studied. We made pre-procedure evaluations of ampullary tumors by using endoscopic ultrasonography (EUS) and transpapillary intraductal ultrasonography. Tumor diameter was measured by EUS. Endoscopic biopsy using immunostaining of Ki-67 labeling index (LI) prior to EP were evaluated.ResultsThe areas under the receiver-operating characteristic (AUROC) curves for tumor diameter and Ki-67 expression were 0.824 and 0.873, respectively. Cut-off values calculated based on AUROC data were 15 mm in tumor diameter and 32 cells/high-power field (HPF) in Ki-67. Early CA (n = 11) was diagnosed by using a cut-off value for tumor diameter in 8 out of 11 patients (sensitivity 72.7 %, specificity 66.7 %, accuracy 68.6 %). Significant infiltration of the major duodenal papilla by Ki-67 positive tumor cells (>31/HPF) was recognized in 8 of the 11 patients with early CA (sensitivity 100 %, specificity 54.2 %, accuracy 62.9 %).ConclusionsObservation of tumor diameter and Ki-67 LI would be helpful for safety EP. EP should not be indicated for ampullary tumors more than 15 mm in diameter and/or Ki-67 LI 31/HPF. More... »

PAGES

531-537

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00534-013-0594-2

DOI

http://dx.doi.org/10.1007/s00534-013-0594-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008969002

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23430056


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30 schema:description BackgroundAmpullary early stage cancer (early CA) potentially harbors lymphovascular invasion; there are few data on markers that could differentiate adenoma and early CA.AimTo investigate those markers, we compared the tumor diameter and Ki-67 expression in endoscopy biopsy specimens of adenoma with those of early CA.MethodsPatients on whom endoscopic papillectomy (EP) was performed (n = 35) with histopathologically proven adenomas and with low/high grade dysplasia and early CA were studied. We made pre-procedure evaluations of ampullary tumors by using endoscopic ultrasonography (EUS) and transpapillary intraductal ultrasonography. Tumor diameter was measured by EUS. Endoscopic biopsy using immunostaining of Ki-67 labeling index (LI) prior to EP were evaluated.ResultsThe areas under the receiver-operating characteristic (AUROC) curves for tumor diameter and Ki-67 expression were 0.824 and 0.873, respectively. Cut-off values calculated based on AUROC data were 15 mm in tumor diameter and 32 cells/high-power field (HPF) in Ki-67. Early CA (n = 11) was diagnosed by using a cut-off value for tumor diameter in 8 out of 11 patients (sensitivity 72.7 %, specificity 66.7 %, accuracy 68.6 %). Significant infiltration of the major duodenal papilla by Ki-67 positive tumor cells (>31/HPF) was recognized in 8 of the 11 patients with early CA (sensitivity 100 %, specificity 54.2 %, accuracy 62.9 %).ConclusionsObservation of tumor diameter and Ki-67 LI would be helpful for safety EP. EP should not be indicated for ampullary tumors more than 15 mm in diameter and/or Ki-67 LI 31/HPF.
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38 Ca
39 ConclusionsObservations
40 Ki-67
41 Ki-67 expression
42 Ki-67 labeling index
43 Ki-67-positive tumor cells
44 MethodsPatients
45 adenomas
46 ampullary tumors
47 area
48 biopsy
49 biopsy specimens
50 cancer
51 cells
52 cells/high power field
53 characteristics
54 cut
55 data
56 diagnostic marker
57 diameter
58 duodenal papilla
59 dysplasia
60 early Ca
61 early-stage cancer
62 endoscopic biopsy
63 endoscopic papillectomy
64 endoscopic ultrasonography
65 evaluation
66 expression
67 field
68 grade dysplasia
69 high-grade dysplasia
70 high-power field
71 index
72 infiltration
73 intraductal ultrasonography
74 invasion
75 labeling index
76 lymphovascular invasion
77 major duodenal papilla
78 markers
79 papillae
80 papillectomy
81 patients
82 positive tumor cells
83 pre-procedure evaluation
84 receiver-operating characteristic
85 significant infiltration
86 specimens
87 stage cancer
88 transpapillary intraductal ultrasonography
89 tumor cells
90 tumor diameter
91 tumors
92 ultrasonography
93 values
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