Endocrine cells in ampullary carcinoma View Full Text


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Article Info

DATE

2009-02-13

AUTHORS

Terumi Kamisawa, Yuyang Tu, Naoto Egawa, Kouji Tsuruta, Atsutake Okamoto, Nobuaki Funata

ABSTRACT

Background/PurposeAs ampullary carcinoma originates from four anatomical regions, it may have different behaviors depending on its origin. We documented the presence of endocrine cells found in ampullary carcinoma, and we studied the clinicopathological implications of their presence.MethodsWe immunohistochemically examined the presence of an endocrine component in 62 surgically resected specimens of ampullary carcinoma, and we studied the clinicopathological differences between endocrine component-positive cases and endocrine component-negative cases.ResultsEndocrine cells were detected in 16 cases (26%); 11 cases had many endocrine cells, and five cases had scattered endocrine cells. Serotonin-positive cells were detected in all 16 cases, in which six cases had many positive cells. Several somatostatin-positive cells were detected in three cases. Endocrine cells were detected in ampulloduodenal polypoid lesions (two cases) and ampullopancreaticobiliary ducts (14 cases). The histology of 15 of the 16 endocrine component-positive ampullary carcinomas was the intestinal type. Pancreatic invasion and lymph node involvement were observed less frequently in endocrine component-positive cases (P < 0.01). There were no significant differences with respect to immunoreactivity for carbohydrate antigen (CA) 19.9, carcinembryonic antigen (CEA), and p53 overexpression, and K-ras mutations.ConclusionsEndocrine component-positive ampullary carcinoma seemed to be derived from the ampullopancreaticobiliary common duct or the ampulloduodenum, and to behave less aggressively than endocrine component-negative carcinoma. More... »

PAGES

322-327

References to SciGraph publications

  • 2004-10. Pathogenesis of carcinoma of the papilla of Vater in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 1999-08-01. p53 and p21/Waf1 protein expression and K-ras codon 12 mutation in carcinoma of the papilla of Vater in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2004-08. Neoplastic diseases of the papilla of Vater in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2003-04-09. Pathogenese und Histopathologie von Adenomen und Karzinomen der Papilla Vateri in DER PATHOLOGE
  • 2002-10. Ductal and Acinar Differentiation in Pancreatic Endocrine Tumors in DIGESTIVE DISEASES AND SCIENCES
  • 2006-11-30. Nodal involvement as an indicator of postoperative liver metastasis in carcinoma of the papilla of Vater in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
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    http://scigraph.springernature.com/pub.10.1007/s00534-009-0048-z

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    http://dx.doi.org/10.1007/s00534-009-0048-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028886937

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19214369


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