Biliopancreatic reflux-pathophysiology and clinical implications. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12-26

AUTHORS

Terumi Kamisawa, Masanao Kurata, Goro Honda, Kouji Tsuruta, Atsutake Okamoto

ABSTRACT

The common bile duct and the main pancreatic duct open into the duodenum, where they frequently form a common channel. The sphincter of Oddi is located at the distal end of the pancreatic and bile ducts; it regulates the outflow of bile and pancreatic juice. In patients with a pancreaticobiliary maljunction, the action of the sphincter does not functionally affect the junction. Therefore, in these patients, two-way regurgitation (pancreatobiliary and biliopancreatic reflux) occurs. This results in various pathological conditions of the biliary tract and the pancreas. Biliopancreatic reflux could be confirmed by: operative or postoperative T-tube cholangiography; CT combined with drip infusion cholangiography; histological detection of gallbladder cancer cells in the main pancreatic duct; and reflux of bile on the cut surface of the pancreas. Biliopancreatic reflux occurs frequently in patients with a long common channel. Although the true prevalence, degree, and pathophysiology of biliopancreatic reflux remain unclear, biliopancreatic reflux is related to the occurrence of acute pancreatitis. Obstruction of a long common channel easily causes bile flow into the pancreas. Even if no obstruction is present, biliopancreatic reflux can still result in acute pancreatitis in some cases. More... »

PAGES

19-24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00534-008-0010-5

DOI

http://dx.doi.org/10.1007/s00534-008-0010-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045846426

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19110654


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207 grid-institutes:grid.415479.a schema:alternateName Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Tokyo, Japan. kamisawa@cick.jp
208 schema:name Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Tokyo, Japan. kamisawa@cick.jp
209 rdf:type schema:Organization
 




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