Ontology type: schema:ScholarlyArticle Open Access: True
2008-01
AUTHORSJunji Furuse, Tadahiro Takada, Masaru Miyazaki, Shuichi Miyakawa, Kazuhiro Tsukada, Masato Nagino, Satoshi Kondo, Hiroya Saito, Toshio Tsuyuguchi, Koichi Hirata, Fumio Kimura, Hideyuki Yoshitomi, Satoshi Nozawa, Masahiro Yoshida, Keita Wada, Hodaka Amano, Fumihiko Miura
ABSTRACTFew randomized controlled trials (RCTs) with large numbers of patients have been conducted to date in patients with biliary tract cancer, and standard chemotherapy has not been established yet. In this article we review previous studies and clinical trials regarding chemotherapy for unresectable biliary tract cancer, and we present guidelines for the appropriate use of chemotherapy in patients with biliary tract cancer. According to an RCT comparing chemotherapy and best supportive care for these patients, survival was significantly longer and quality of life was significantly better in the chemotherapy group than in the control group. Thus, chemotherapy for patients with biliary tract cancer seems to be a significant treatment of choice. However, chemotherapy for patients with biliary tract cancer should be indicated for those with unresectable, locally advanced disease or distant metastasis, or for those with recurrence after resection. That is why making the diagnosis of unresectable disease should be done with greatest care. As a rule, pathological diagnosis, including cytology or histopathological diagnosis, is preferable. Chemotherapy is recommended in patients with a good general condition, because in patients with general deterioration, such as those with a performance status of 2 or 3 or those with insufficient biliary decompression, the benefit of chemotherapy is limited. As chemotherapy for unresectable biliary tract cancer, the use of gemcitabine or tegafur/gimeracil/oteracil potassium is recommended. As postoperative adjuvant chemotherapy, no effective adjuvant therapy has been established at the present time. It is recommended that further clinical trials, especially large multi-institutional RCTs (phase III studies) using novel agents such as gemcitabine should be performed as soon as possible in order to establish a standard treatment. More... »
PAGES55-62
http://scigraph.springernature.com/pub.10.1007/s00534-007-1280-z
DOIhttp://dx.doi.org/10.1007/s00534-007-1280-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1017686721
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18274844
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ampulla of Vater",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biliary Tract Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemotherapy, Adjuvant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Evidence-Based Medicine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Randomized Controlled Trials as Topic",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi, Chiba, 277-8577 Japan",
"id": "http://www.grid.ac/institutes/grid.497282.2",
"name": [
"Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi, Chiba, 277-8577 Japan"
],
"type": "Organization"
},
"familyName": "Furuse",
"givenName": "Junji",
"id": "sg:person.01154650450.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154650450.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.264706.1",
"name": [
"Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Takada",
"givenName": "Tadahiro",
"id": "sg:person.01145073410.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145073410.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan",
"id": "http://www.grid.ac/institutes/grid.136304.3",
"name": [
"Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"
],
"type": "Organization"
},
"familyName": "Miyazaki",
"givenName": "Masaru",
"id": "sg:person.0773025611.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773025611.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Gastroenterological Surgery, Fujita Health University, Toyoake, Japan",
"id": "http://www.grid.ac/institutes/grid.256115.4",
"name": [
"Department of Gastroenterological Surgery, Fujita Health University, Toyoake, Japan"
],
"type": "Organization"
},
"familyName": "Miyakawa",
"givenName": "Shuichi",
"id": "sg:person.012517244744.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012517244744.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan",
"id": "http://www.grid.ac/institutes/grid.267346.2",
"name": [
"Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan"
],
"type": "Organization"
},
"familyName": "Tsukada",
"givenName": "Kazuhiro",
"id": "sg:person.01233146520.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233146520.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.27476.30",
"name": [
"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Nagino",
"givenName": "Masato",
"id": "sg:person.01211606464.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211606464.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan",
"id": "http://www.grid.ac/institutes/grid.39158.36",
"name": [
"Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"
],
"type": "Organization"
},
"familyName": "Kondo",
"givenName": "Satoshi",
"id": "sg:person.01264520473.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264520473.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Asahikawa Kosei General Hospital, Asahikawa, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Radiology, Asahikawa Kosei General Hospital, Asahikawa, Japan"
],
"type": "Organization"
},
"familyName": "Saito",
"givenName": "Hiroya",
"id": "sg:person.01245744760.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245744760.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan",
"id": "http://www.grid.ac/institutes/grid.136304.3",
"name": [
"Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan"
],
"type": "Organization"
},
"familyName": "Tsuyuguchi",
"givenName": "Toshio",
"id": "sg:person.0727433030.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727433030.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgical Oncology and Gastroenterological Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan",
"id": "http://www.grid.ac/institutes/grid.263171.0",
"name": [
"Department of Surgical Oncology and Gastroenterological Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan"
],
"type": "Organization"
},
"familyName": "Hirata",
"givenName": "Koichi",
"id": "sg:person.015313514313.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015313514313.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan",
"id": "http://www.grid.ac/institutes/grid.136304.3",
"name": [
"Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"
],
"type": "Organization"
},
"familyName": "Kimura",
"givenName": "Fumio",
"id": "sg:person.01127754745.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127754745.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan",
"id": "http://www.grid.ac/institutes/grid.136304.3",
"name": [
"Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"
],
"type": "Organization"
},
"familyName": "Yoshitomi",
"givenName": "Hideyuki",
"id": "sg:person.01245062664.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245062664.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan",
"id": "http://www.grid.ac/institutes/grid.136304.3",
"name": [
"Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan"
],
"type": "Organization"
},
"familyName": "Nozawa",
"givenName": "Satoshi",
"id": "sg:person.01267524127.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267524127.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.264706.1",
"name": [
"Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yoshida",
"givenName": "Masahiro",
"id": "sg:person.01130041525.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130041525.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.264706.1",
"name": [
"Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Wada",
"givenName": "Keita",
"id": "sg:person.01162577627.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162577627.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.264706.1",
"name": [
"Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Amano",
"givenName": "Hodaka",
"id": "sg:person.01167775323.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167775323.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.264706.1",
"name": [
"Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Miura",
"givenName": "Fumihiko",
"id": "sg:person.01115635730.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115635730.35"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/sj.bjc.6601736",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016846770",
"https://doi.org/10.1038/sj.bjc.6601736"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/b:drug.0000011797.09549.53",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038864503",
"https://doi.org/10.1023/b:drug.0000011797.09549.53"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6602576",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052616134",
"https://doi.org/10.1038/sj.bjc.6602576"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6601796",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008635604",
"https://doi.org/10.1038/sj.bjc.6601796"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1385/ijgc:32:2-3:107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038909402",
"https://doi.org/10.1385/ijgc:32:2-3:107"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6602208",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015354465",
"https://doi.org/10.1038/sj.bjc.6602208"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6600543",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016551013",
"https://doi.org/10.1038/sj.bjc.6600543"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-007-0673-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013512506",
"https://doi.org/10.1007/s00280-007-0673-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00534-007-1274-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024299938",
"https://doi.org/10.1007/s00534-007-1274-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1016209901417",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015634355",
"https://doi.org/10.1023/a:1016209901417"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-005-0095-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030889660",
"https://doi.org/10.1007/s00280-005-0095-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1006268018519",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035563235",
"https://doi.org/10.1023/a:1006268018519"
],
"type": "CreativeWork"
}
],
"datePublished": "2008-01",
"datePublishedReg": "2008-01-01",
"description": "Few randomized controlled trials (RCTs) with large numbers of patients have been conducted to date in patients with biliary tract cancer, and standard chemotherapy has not been established yet. In this article we review previous studies and clinical trials regarding chemotherapy for unresectable biliary tract cancer, and we present guidelines for the appropriate use of chemotherapy in patients with biliary tract cancer. According to an RCT comparing chemotherapy and best supportive care for these patients, survival was significantly longer and quality of life was significantly better in the chemotherapy group than in the control group. Thus, chemotherapy for patients with biliary tract cancer seems to be a significant treatment of choice. However, chemotherapy for patients with biliary tract cancer should be indicated for those with unresectable, locally advanced disease or distant metastasis, or for those with recurrence after resection. That is why making the diagnosis of unresectable disease should be done with greatest care. As a rule, pathological diagnosis, including cytology or histopathological diagnosis, is preferable. Chemotherapy is recommended in patients with a good general condition, because in patients with general deterioration, such as those with a performance status of 2 or 3 or those with insufficient biliary decompression, the benefit of chemotherapy is limited. As chemotherapy for unresectable biliary tract cancer, the use of gemcitabine or tegafur/gimeracil/oteracil potassium is recommended. As postoperative adjuvant chemotherapy, no effective adjuvant therapy has been established at the present time. It is recommended that further clinical trials, especially large multi-institutional RCTs (phase III studies) using novel agents such as gemcitabine should be performed as soon as possible in order to establish a standard treatment.",
"genre": "article",
"id": "sg:pub.10.1007/s00534-007-1280-z",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1043285",
"issn": [
"1868-6974",
"1868-6982"
],
"name": "Journal of Hepato-Biliary-Pancreatic Sciences",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "15"
}
],
"keywords": [
"biliary tract cancer",
"unresectable biliary tract cancer",
"tract cancer",
"clinical trials",
"tegafur/gimeracil/oteracil potassium",
"postoperative adjuvant chemotherapy",
"multi-institutional RCTs",
"best supportive care",
"good general condition",
"benefit of chemotherapy",
"use of gemcitabine",
"effective adjuvant therapy",
"further clinical trials",
"quality of life",
"oteracil potassium",
"chemotherapy group",
"unresectable disease",
"biliary decompression",
"adjuvant chemotherapy",
"supportive care",
"advanced disease",
"performance status",
"adjuvant therapy",
"standard chemotherapy",
"distant metastasis",
"biliary tract",
"ampullary carcinoma",
"standard treatment",
"pathological diagnosis",
"histopathological diagnosis",
"novel agents",
"chemotherapy",
"patients",
"control group",
"cancer",
"significant treatment",
"diagnosis",
"trials",
"appropriate use",
"RCTs",
"gemcitabine",
"disease",
"care",
"treatment",
"general condition",
"general deterioration",
"guidelines",
"previous studies",
"resection",
"group",
"recurrence",
"carcinoma",
"metastasis",
"therapy",
"cytology",
"tract",
"decompression",
"survival",
"status",
"great care",
"agents",
"use",
"deterioration",
"present time",
"study",
"life",
"benefits",
"potassium",
"date",
"large number",
"quality",
"number",
"time",
"choice",
"conditions",
"article",
"order",
"rules",
"insufficient biliary decompression",
"gimeracil/oteracil potassium",
"large multi-institutional RCTs"
],
"name": "Guidelines for chemotherapy of biliary tract and ampullary carcinomas",
"pagination": "55-62",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1017686721"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00534-007-1280-z"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"18274844"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00534-007-1280-z",
"https://app.dimensions.ai/details/publication/pub.1017686721"
],
"sdDataset": "articles",
"sdDatePublished": "2022-01-01T18:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_473.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00534-007-1280-z"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00534-007-1280-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00534-007-1280-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00534-007-1280-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00534-007-1280-z'
This table displays all metadata directly associated to this object as RDF triples.
361 TRIPLES
22 PREDICATES
127 URIs
107 LITERALS
15 BLANK NODES