Risk factors for biliary tract and ampullary carcinomas and prophylactic surgery for these factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-01

AUTHORS

Masaru Miyazaki, Tadahiro Takada, Shuichi Miyakawa, Kazuhiro Tsukada, Masato Nagino, Satoshi Kondo, Junji Furuse, Hiroya Saito, Toshio Tsuyuguchi, Kazuo Chijiiwa, Fumio Kimura, Hideyuki Yoshitomi, Satoshi Nozawa, Masahiro Yoshida, Keita Wada, Hodaka Amano, Fumihiko Miura

ABSTRACT

Curative resection is the only treatment for biliary tract cancer that achieves long-term survival. However, patients with advanced biliary tract cancer have only a limited prognosis even after radical surgical resection. Thus, to improve the longterm results, the early detection of biliary tract cancer and subsequent cure seem to be essential. The purpose of this study was to review the literature concerning the risk factors for cancerous and precancerous lesions of the biliary tract, and prophylactic surgery for these factors. It has been reported that pancreaticobiliary maljunction (PBM) with bile duct dilatation is a risk factor for gallbladder cancer and bile duct cancer, while PBM without bile duct dilatation is a risk factor for gallbladder cancer. Thus, in the former group, a prophylactic excision of the common bile duct and gallbladder should be recommended, while in the later group, a prophylactic cholecystectomy without bile duct resection may be the appropriate surgical procedure. It has also been reported that primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma. Patients with PSC often develop advanced cholangiocarcinoma with a poor prognosis. In patients with PSC, therefore, strict follow-up should be recommended. Adenoma and dysplasia have been regarded as precancerous lesions of gallbladder cancer. A polypoid lesion of the gallbladder that is sessile, has a diameter greater than 10 mm, and /or grows rapidly, is highly likely to be cancerous and should be resected. Although gallstones seem to be closely associated with gallbladder cancer, there is no evidence of a direct causal relationship between gallstones and gallbladder cancer. Thus, a cholecystectomy is not advised for asymptomatic cholecystolithiasis. Controversy remains as to whether adenomyomatosis of the gallbladder and porcelain gallbladder are associated with gallbladder cancer. With respect to ampullary carcinoma, adenoma of the ampulla is considered to be a precancerous lesion. This article discusses the risk factors for cancerous and precancerous lesions of the biliary tract and prophylactic treatment for these factors. More... »

PAGES

15-24

References to SciGraph publications

  • 1999-04. Biliary tract inflammatory disorders: Primary sclerosing cholangitis and primary biliary cirrhosis in CURRENT GASTROENTEROLOGY REPORTS
  • 2003-10. Pancreaticobiliary maljunction: retrospective and nationwide survey in Japan in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2000-06-01. Primary gallbladder cancer: recognition of risk factors and the role of prophylactic cholecystectomy in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2008-01. Purpose, use, and preparation of clinical practice guidelines for the management of biliary tract and ampullary carcinomas in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2006-02. Can Endoscopic Ultrasonography Differentiate Nonneoplastic from Neoplastic Gallbladder Polyps? in DIGESTIVE DISEASES AND SCIENCES
  • 2001-07. Expression of Oncogene Products HER2/Neu and Ras and Fibrosis-Related Growth Factors bFGF, TGF-β, and PDGF in Bile from Biliary Malignancies and Inflammatory Disorders in DIGESTIVE DISEASES AND SCIENCES
  • 2000-04. Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2003-04-09. Pancreaticobiliary maljunction: pathophysiological and clinical aspects and the impact on biliary carcinogenesis in LANGENBECK'S ARCHIVES OF SURGERY
  • 2004-08. Neoplastic diseases of the papilla of Vater in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2001-04. Carcinogenesis of malignant lesions of the gall bladder in LANGENBECK'S ARCHIVES OF SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00534-007-1276-8

    DOI

    http://dx.doi.org/10.1007/s00534-007-1276-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042390007

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18274840


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