Analysis of microvessels in pancreatic cancer: by light microscopy, confocal laser scan microscopy, and electron microscopy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07

AUTHORS

Kenji Takagi, Tadahiro Takada, Hodaka Amano, Masahiro Yoshida, Humihiko Miura, Naoyuki Toyota, Keita Wada, Ichirou Takahashi

ABSTRACT

Background/PurposeThe microvessel density (MVD) of most malignant tumors is considered to be strongly related to metastasis and prognosis. Weidner’s “hot spot method” for determining MVD is in general use, but it is possible that cells other than endothelial cells will also be stained. In our previous study, no correlations were observed between MVD determined by the “hot spot method” and prognosis/metastasis. But, using the “lumen method,” we found a correlation with the number of vessel structures only. In the present study, we analyzed the staining of microvessels in pancreatic cancer, using light microscopy, confocal laser scan microscopy (CLSM), and transmission electron microscopy (TEM).MethodsMicrovessel staining of pancreatic cancer with CD34, factor VIII, and CD45 antibodies was examined in consecutive slices by light microscopy. For CLSM, freshly resected specimens were immunostained with factor VIII and fluorescein isothiocynate. For TEM, specimens were fixed with 2.5% glutaraldehyde, treated with 1% osmium tetroxide, and embedded in epoxy resin.ResultsStaining of vessels with CD34 and factor VIII antibodies appeared similar under light microscopy. However, CD34-stained consecutive slices were judged not to reveal vessel structures, and some cells stained with CD45 antibody were similar in appearance to CD34-stained cells. Under CLSM, irregular arrangements of neovascularization, consisting of many branches, were observed, but many positively stained cells not identified as vessels were also seen. Microvessels were distinctly identified under TEM, but the types of individual cells could not be determined.ConclusionsAn integrated, reproducible method for the measurement of MVD is vital. For pancreatic cancer, the “lumen method” is recommended. More... »

PAGES

384-390

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00534-007-1241-6

DOI

http://dx.doi.org/10.1007/s00534-007-1241-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038938977

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18670839


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Confocal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microvessels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takagi", 
        "givenName": "Kenji", 
        "id": "sg:person.0600320004.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600320004.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takada", 
        "givenName": "Tadahiro", 
        "id": "sg:person.01145073410.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145073410.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amano", 
        "givenName": "Hodaka", 
        "id": "sg:person.01167775323.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167775323.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Masahiro", 
        "id": "sg:person.01130041525.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130041525.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miura", 
        "givenName": "Humihiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toyota", 
        "givenName": "Naoyuki", 
        "id": "sg:person.01315172576.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315172576.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wada", 
        "givenName": "Keita", 
        "id": "sg:person.01162577627.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162577627.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Laboratory for Electron Microscopy, Teikyo University School of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Central Laboratory for Electron Microscopy, Teikyo University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Ichirou", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1014010801754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022465370", 
          "https://doi.org/10.1023/a:1014010801754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-004-1556-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035821769", 
          "https://doi.org/10.1007/s00535-004-1556-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003090106", 
          "https://doi.org/10.1038/sj.bjc.6690248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s005340070020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009097716", 
          "https://doi.org/10.1007/s005340070020"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-07", 
    "datePublishedReg": "2008-07-01", 
    "description": "Background/PurposeThe microvessel density (MVD) of most malignant tumors is considered to be strongly related to metastasis and prognosis. Weidner\u2019s \u201chot spot method\u201d for determining MVD is in general use, but it is possible that cells other than endothelial cells will also be stained. In our previous study, no correlations were observed between MVD determined by the \u201chot spot method\u201d and prognosis/metastasis. But, using the \u201clumen method,\u201d we found a correlation with the number of vessel structures only. In the present study, we analyzed the staining of microvessels in pancreatic cancer, using light microscopy, confocal laser scan microscopy (CLSM), and transmission electron microscopy (TEM).MethodsMicrovessel staining of pancreatic cancer with CD34, factor VIII, and CD45 antibodies was examined in consecutive slices by light microscopy. For CLSM, freshly resected specimens were immunostained with factor VIII and fluorescein isothiocynate. For TEM, specimens were fixed with 2.5% glutaraldehyde, treated with 1% osmium tetroxide, and embedded in epoxy resin.ResultsStaining of vessels with CD34 and factor VIII antibodies appeared similar under light microscopy. However, CD34-stained consecutive slices were judged not to reveal vessel structures, and some cells stained with CD45 antibody were similar in appearance to CD34-stained cells. Under CLSM, irregular arrangements of neovascularization, consisting of many branches, were observed, but many positively stained cells not identified as vessels were also seen. Microvessels were distinctly identified under TEM, but the types of individual cells could not be determined.ConclusionsAn integrated, reproducible method for the measurement of MVD is vital. For pancreatic cancer, the \u201clumen method\u201d is recommended.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00534-007-1241-6", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1043285", 
        "issn": [
          "1868-6974", 
          "1868-6982"
        ], 
        "name": "Journal of Hepato-Biliary-Pancreatic Sciences", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "keywords": [
      "pancreatic cancer", 
      "microvessel density", 
      "confocal laser scan microscopy", 
      "CD45 antibody", 
      "hot spot method", 
      "factor VIII", 
      "laser scan microscopy", 
      "factor VIII antibodies", 
      "most malignant tumors", 
      "light microscopy", 
      "malignant tumors", 
      "VIII antibodies", 
      "measurement of MVD", 
      "cancer", 
      "endothelial cells", 
      "spot method", 
      "consecutive slices", 
      "microvessels", 
      "analysis of microvessels", 
      "antibodies", 
      "metastasis", 
      "vessel structure", 
      "CD34", 
      "present study", 
      "staining", 
      "cells", 
      "vessels", 
      "reproducible method", 
      "previous studies", 
      "irregular arrangement", 
      "slices", 
      "prognosis", 
      "tumors", 
      "VIII", 
      "neovascularization", 
      "study", 
      "specimens", 
      "correlation", 
      "general use", 
      "individual cells", 
      "fluorescein", 
      "appearance", 
      "osmium tetroxide", 
      "use", 
      "electron microscopy", 
      "method", 
      "microscopy", 
      "number", 
      "types", 
      "Weidner", 
      "glutaraldehyde", 
      "analysis", 
      "branches", 
      "lumen method", 
      "transmission electron microscopy", 
      "measurements", 
      "tetroxide", 
      "density", 
      "structure", 
      "arrangement", 
      "resin", 
      "Integrated", 
      "epoxy resin", 
      "Background/PurposeThe microvessel density", 
      "PurposeThe microvessel density", 
      "prognosis/metastasis", 
      "staining of microvessels", 
      "scan microscopy", 
      "MethodsMicrovessel staining", 
      "CD34-stained consecutive slices", 
      "CD34-stained cells", 
      "ConclusionsAn integrated"
    ], 
    "name": "Analysis of microvessels in pancreatic cancer: by light microscopy, confocal laser scan microscopy, and electron microscopy", 
    "pagination": "384-390", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038938977"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00534-007-1241-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18670839"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00534-007-1241-6", 
      "https://app.dimensions.ai/details/publication/pub.1038938977"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_466.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00534-007-1241-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00534-007-1241-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00534-007-1241-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00534-007-1241-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00534-007-1241-6'


 

This table displays all metadata directly associated to this object as RDF triples.

231 TRIPLES      22 PREDICATES      111 URIs      99 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00534-007-1241-6 schema:about N2394b43f2773446c89ae63f99a92e06a
2 N3d8d0e48519e48e592dc612fa0a38661
3 N446f9dd274274a20812bca89845d7462
4 N6afa06cf1ba6434d9c549d4e55f90892
5 N7089ecaebb5144b7b741cc377fdea3d7
6 N72ff193ea43947d1af4eb5a2d0001c1c
7 Nacc47ac756f5422e9235dc82a0373152
8 Ne582714808554c3c8d636bb5601ed57a
9 anzsrc-for:11
10 anzsrc-for:1112
11 schema:author N48d8be07c6444748bf7e6ce29363dcd5
12 schema:citation sg:pub.10.1007/s005340070020
13 sg:pub.10.1007/s00535-004-1556-x
14 sg:pub.10.1023/a:1014010801754
15 sg:pub.10.1038/sj.bjc.6690248
16 schema:datePublished 2008-07
17 schema:datePublishedReg 2008-07-01
18 schema:description Background/PurposeThe microvessel density (MVD) of most malignant tumors is considered to be strongly related to metastasis and prognosis. Weidner’s “hot spot method” for determining MVD is in general use, but it is possible that cells other than endothelial cells will also be stained. In our previous study, no correlations were observed between MVD determined by the “hot spot method” and prognosis/metastasis. But, using the “lumen method,” we found a correlation with the number of vessel structures only. In the present study, we analyzed the staining of microvessels in pancreatic cancer, using light microscopy, confocal laser scan microscopy (CLSM), and transmission electron microscopy (TEM).MethodsMicrovessel staining of pancreatic cancer with CD34, factor VIII, and CD45 antibodies was examined in consecutive slices by light microscopy. For CLSM, freshly resected specimens were immunostained with factor VIII and fluorescein isothiocynate. For TEM, specimens were fixed with 2.5% glutaraldehyde, treated with 1% osmium tetroxide, and embedded in epoxy resin.ResultsStaining of vessels with CD34 and factor VIII antibodies appeared similar under light microscopy. However, CD34-stained consecutive slices were judged not to reveal vessel structures, and some cells stained with CD45 antibody were similar in appearance to CD34-stained cells. Under CLSM, irregular arrangements of neovascularization, consisting of many branches, were observed, but many positively stained cells not identified as vessels were also seen. Microvessels were distinctly identified under TEM, but the types of individual cells could not be determined.ConclusionsAn integrated, reproducible method for the measurement of MVD is vital. For pancreatic cancer, the “lumen method” is recommended.
19 schema:genre article
20 schema:inLanguage en
21 schema:isAccessibleForFree false
22 schema:isPartOf Na2475e99befe46618eaaca6514d972f2
23 Nd4c86a3631314e2fb3df3e14e2fb3b05
24 sg:journal.1043285
25 schema:keywords Background/PurposeThe microvessel density
26 CD34
27 CD34-stained cells
28 CD34-stained consecutive slices
29 CD45 antibody
30 ConclusionsAn integrated
31 Integrated
32 MethodsMicrovessel staining
33 PurposeThe microvessel density
34 VIII
35 VIII antibodies
36 Weidner
37 analysis
38 analysis of microvessels
39 antibodies
40 appearance
41 arrangement
42 branches
43 cancer
44 cells
45 confocal laser scan microscopy
46 consecutive slices
47 correlation
48 density
49 electron microscopy
50 endothelial cells
51 epoxy resin
52 factor VIII
53 factor VIII antibodies
54 fluorescein
55 general use
56 glutaraldehyde
57 hot spot method
58 individual cells
59 irregular arrangement
60 laser scan microscopy
61 light microscopy
62 lumen method
63 malignant tumors
64 measurement of MVD
65 measurements
66 metastasis
67 method
68 microscopy
69 microvessel density
70 microvessels
71 most malignant tumors
72 neovascularization
73 number
74 osmium tetroxide
75 pancreatic cancer
76 present study
77 previous studies
78 prognosis
79 prognosis/metastasis
80 reproducible method
81 resin
82 scan microscopy
83 slices
84 specimens
85 spot method
86 staining
87 staining of microvessels
88 structure
89 study
90 tetroxide
91 transmission electron microscopy
92 tumors
93 types
94 use
95 vessel structure
96 vessels
97 schema:name Analysis of microvessels in pancreatic cancer: by light microscopy, confocal laser scan microscopy, and electron microscopy
98 schema:pagination 384-390
99 schema:productId N3de481d5bdd14b0a9c2491280575efa0
100 N876013aee57b423296c2c7cc5d451d25
101 Nf596cf7238d14fafa12f1bd8e70a1a78
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038938977
103 https://doi.org/10.1007/s00534-007-1241-6
104 schema:sdDatePublished 2022-01-01T18:19
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher Nfb0f472adb7741d2ab565e0e71396fda
107 schema:url https://doi.org/10.1007/s00534-007-1241-6
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N06b63b70501b4540a68a4ac305219ad7 rdf:first sg:person.01315172576.20
112 rdf:rest N9b1cd7f326a44e40b1e1f6625dc5cee5
113 N2394b43f2773446c89ae63f99a92e06a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Pancreatic Neoplasms
115 rdf:type schema:DefinedTerm
116 N3d8d0e48519e48e592dc612fa0a38661 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Microscopy, Confocal
118 rdf:type schema:DefinedTerm
119 N3de481d5bdd14b0a9c2491280575efa0 schema:name doi
120 schema:value 10.1007/s00534-007-1241-6
121 rdf:type schema:PropertyValue
122 N446f9dd274274a20812bca89845d7462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Immunohistochemistry
124 rdf:type schema:DefinedTerm
125 N48d8be07c6444748bf7e6ce29363dcd5 rdf:first sg:person.0600320004.12
126 rdf:rest Nf50e21d96a4e4e9fbc6e6f7b1b20adb3
127 N578b5ecf721944a391648a0298609cfd schema:affiliation grid-institutes:grid.264706.1
128 schema:familyName Takahashi
129 schema:givenName Ichirou
130 rdf:type schema:Person
131 N5d64855d2ec34b14bd4bd1fc1608390f rdf:first sg:person.01167775323.13
132 rdf:rest N71a43aa1ded24b34beddafda9fbce59d
133 N6afa06cf1ba6434d9c549d4e55f90892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Microscopy, Electron
135 rdf:type schema:DefinedTerm
136 N7089ecaebb5144b7b741cc377fdea3d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Humans
138 rdf:type schema:DefinedTerm
139 N71a43aa1ded24b34beddafda9fbce59d rdf:first sg:person.01130041525.07
140 rdf:rest N8aff7873b0314ea499a5e85065cc5616
141 N72ff193ea43947d1af4eb5a2d0001c1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Neovascularization, Pathologic
143 rdf:type schema:DefinedTerm
144 N876013aee57b423296c2c7cc5d451d25 schema:name dimensions_id
145 schema:value pub.1038938977
146 rdf:type schema:PropertyValue
147 N8aff7873b0314ea499a5e85065cc5616 rdf:first Na5ab2c5750374305a9443cb5b112b7ac
148 rdf:rest N06b63b70501b4540a68a4ac305219ad7
149 N9b1cd7f326a44e40b1e1f6625dc5cee5 rdf:first sg:person.01162577627.41
150 rdf:rest Nad5383416e17483ca68b8a2a959a0de5
151 Na2475e99befe46618eaaca6514d972f2 schema:volumeNumber 15
152 rdf:type schema:PublicationVolume
153 Na5ab2c5750374305a9443cb5b112b7ac schema:affiliation grid-institutes:grid.264706.1
154 schema:familyName Miura
155 schema:givenName Humihiko
156 rdf:type schema:Person
157 Nacc47ac756f5422e9235dc82a0373152 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Carcinoma, Pancreatic Ductal
159 rdf:type schema:DefinedTerm
160 Nad5383416e17483ca68b8a2a959a0de5 rdf:first N578b5ecf721944a391648a0298609cfd
161 rdf:rest rdf:nil
162 Nd4c86a3631314e2fb3df3e14e2fb3b05 schema:issueNumber 4
163 rdf:type schema:PublicationIssue
164 Ne582714808554c3c8d636bb5601ed57a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Microvessels
166 rdf:type schema:DefinedTerm
167 Nf50e21d96a4e4e9fbc6e6f7b1b20adb3 rdf:first sg:person.01145073410.03
168 rdf:rest N5d64855d2ec34b14bd4bd1fc1608390f
169 Nf596cf7238d14fafa12f1bd8e70a1a78 schema:name pubmed_id
170 schema:value 18670839
171 rdf:type schema:PropertyValue
172 Nfb0f472adb7741d2ab565e0e71396fda schema:name Springer Nature - SN SciGraph project
173 rdf:type schema:Organization
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
178 schema:name Oncology and Carcinogenesis
179 rdf:type schema:DefinedTerm
180 sg:journal.1043285 schema:issn 1868-6974
181 1868-6982
182 schema:name Journal of Hepato-Biliary-Pancreatic Sciences
183 schema:publisher Springer Nature
184 rdf:type schema:Periodical
185 sg:person.01130041525.07 schema:affiliation grid-institutes:grid.264706.1
186 schema:familyName Yoshida
187 schema:givenName Masahiro
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130041525.07
189 rdf:type schema:Person
190 sg:person.01145073410.03 schema:affiliation grid-institutes:grid.264706.1
191 schema:familyName Takada
192 schema:givenName Tadahiro
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145073410.03
194 rdf:type schema:Person
195 sg:person.01162577627.41 schema:affiliation grid-institutes:grid.264706.1
196 schema:familyName Wada
197 schema:givenName Keita
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162577627.41
199 rdf:type schema:Person
200 sg:person.01167775323.13 schema:affiliation grid-institutes:grid.264706.1
201 schema:familyName Amano
202 schema:givenName Hodaka
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167775323.13
204 rdf:type schema:Person
205 sg:person.01315172576.20 schema:affiliation grid-institutes:grid.264706.1
206 schema:familyName Toyota
207 schema:givenName Naoyuki
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315172576.20
209 rdf:type schema:Person
210 sg:person.0600320004.12 schema:affiliation grid-institutes:grid.264706.1
211 schema:familyName Takagi
212 schema:givenName Kenji
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600320004.12
214 rdf:type schema:Person
215 sg:pub.10.1007/s005340070020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009097716
216 https://doi.org/10.1007/s005340070020
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s00535-004-1556-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035821769
219 https://doi.org/10.1007/s00535-004-1556-x
220 rdf:type schema:CreativeWork
221 sg:pub.10.1023/a:1014010801754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022465370
222 https://doi.org/10.1023/a:1014010801754
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/sj.bjc.6690248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003090106
225 https://doi.org/10.1038/sj.bjc.6690248
226 rdf:type schema:CreativeWork
227 grid-institutes:grid.264706.1 schema:alternateName Central Laboratory for Electron Microscopy, Teikyo University School of Medicine, Tokyo, Japan
228 Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan
229 schema:name Central Laboratory for Electron Microscopy, Teikyo University School of Medicine, Tokyo, Japan
230 Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga-cho, Itabashi-ku, 173-8606, Tokyo, Japan
231 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...