Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-04-30

AUTHORS

Chang Hu, Jialing Tang, Yang Gao, Ran Cao

ABSTRACT

BackgroundA growing number of articles had reported the beneficial effects of physical exercise on reduced risks of cancer recurrence and mortality. However, the associations between physical exercise and laboratory biomarkers still had controversy. As we knew, this meta-analysis of randomized controlled trials (RCTs) was the first time for us to comprehensively clarify their relationships in cancer patients.MethodsWe comprehensively searched the PubMed, Cochrane Central, EMBASE, Web of Science, and SportDiscus online databases to identify eligible articles, up to June 1, 2021. Pooled standardized mean differences (SMDs) with 95% confidence intervals (CIs) were utilized to clarify their associations. Sensitivity analysis was performed to assess the impact of the individual on overall and Begg’s/Egger’s plot was utilized to evaluate potential publication bias.ResultsFinally, 35 randomized controlled trials (RCTs) were finally enrolled in this meta-analysis. Our results indicated that physical exercise could significantly reduce BMI (pooled SMD = −0.32 − 0.56 to −0.09)), body weight (pooled SMD = −0.31 (−0.54 to −0.08)), body fat (pooled SMD = −0.44 (−0.70 to −0.18)), waist circumference (pooled SMD = −0.50 (−0.76 to −0.23)), hip circumference (pooled SMD = −0.54 (−0.80 to −0.28)), triglyceride (pooled SMD = −0.35 (−0.69 to −0.02)), fasting insulin (pooled SMD = −0.38 (−0.54 to −0.22)), glucose (pooled SMD = −0.56 (−0.84 to −0.28)), insulin resistance (pooled SMD = −0.40 (−0.72 to −0.07)), CRP (pooled SMD = −0.97 (−1.48 to −0.46)), IGF-1 levels (pooled SMD = −0.56 (−0.83 to −0.29)) and remarkably increase IGFBP-3 levels (pooled SMD = 0.81 (0.45 to 1.17)). Further sensitivity analysis and Begg’s or Egger’s test suggested that our results were robust with no significant publication bias.ConclusionsOur results shed light on the beneficial effects of physical exercise on cancer patients by means of BMI/weight change and various biomarkers alteration (insulin-glucose pathways or inflammatory biomarkers). Our results were anticipated for clinical application to improve cancer patients’ prognosis. More... »

PAGES

1-12

References to SciGraph publications

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  • 2011-02-19. Effects of a Weight Loss Intervention on Body Mass, Fitness, and Inflammatory Biomarkers in Overweight or Obese Breast Cancer Survivors in INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
  • 2015-03-01. Exercise and dietary advice intervention for survivors of triple-negative breast cancer: effects on body fat, physical function, quality of life, and adipokine profile in SUPPORTIVE CARE IN CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00520-022-07013-6

    DOI

    http://dx.doi.org/10.1007/s00520-022-07013-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147558392

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35501513


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    38 EMBASE
    39 Egger plot
    40 Egger's test
    41 Further sensitivity analysis
    42 IGF-1 levels
    43 IGFBP-3 levels
    44 MethodsWe
    45 PubMed
    46 ResultsFinally
    47 SPORTDiscus
    48 Web
    49 Web of Science
    50 alterations
    51 analysis
    52 applications
    53 article
    54 association
    55 beneficial effects
    56 bias
    57 biomarker alterations
    58 biomarkers
    59 body fat
    60 body weight
    61 cancer patients
    62 cancer recurrence
    63 changes
    64 circumference
    65 clinical application
    66 confidence intervals
    67 controversy
    68 differences
    69 effect
    70 eligible articles
    71 exercise
    72 fat
    73 first time
    74 glucose
    75 hip circumference
    76 impact
    77 individuals
    78 insulin
    79 insulin resistance
    80 interval
    81 laboratory biomarkers
    82 levels
    83 light
    84 mean difference
    85 means
    86 mortality
    87 number
    88 number of articles
    89 patients
    90 physical exercise
    91 plots
    92 potential publication bias
    93 prognosis
    94 publication bias
    95 recurrence
    96 reduced risk
    97 relationship
    98 resistance
    99 results
    100 risk
    101 science
    102 sensitivity analysis
    103 significant publication bias
    104 standardized mean difference
    105 test
    106 time
    107 trials
    108 triglycerides
    109 waist circumference
    110 weight
    111 weight change
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