Evaluation of indices for predicting recovery of exercise tolerance in patients surviving allogenic hematopoietic stem cell transplantation View Full Text


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Article Info

DATE

2022-01-22

AUTHORS

Ryota Hamada, Tadakazu Kondo, Kazuhiro Harada, Masanobu Murao, Junsuke Miyasaka, Michiko Yoshida, Honami Yonezawa, Manabu Nankaku, Yasuyuki Arai, Junya Kanda, Akifumi Takaori-Kondo, Ryosuke Ikeguchi, Shuichi Matsuda

ABSTRACT

PurposeDecline in physical function in the early stage after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a major challenge. Exercise tolerance tests, such as the 6-min walk test, are useful markers for predicting exercise tolerance and various other traits, including cardiometabolic risk and non-relapse mortality. This retrospective cohort study aimed to investigate and identify predictors of recovery of exercise tolerance in the early stage after allo-HSCT.MethodsNinety-eight patients were classified into recovery and non-recovery groups according to the median 6-min walk distance (6MWD) at discharge.ResultsLogistic regression analysis revealed that pre-post change in knee extensor strength (ΔKES) and hematopoietic cell transplantation comorbidity index were useful predictors of recovery of exercise tolerance at discharge and moderate predictors of 6MWD recovery in the early post-transplant period. Receiver operating characteristic analysis showed that pre-transplant ΔKES was an accurate predictor of 6MWD recovery in the early post-transplant period. The cutoff point for ΔKES calculated using the Youden index was − 1.17 Nm/kg.ConclusionsThe results of this study emphasize the importance of the need for programs designed to prevent muscle weakness in the early period after allo-HSCT. The results from markers of recovery of exercise tolerance are promising and can be used for patient education in rehabilitation programs after allo-HSCT. More... »

PAGES

4027-4034

References to SciGraph publications

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  • 2005-02-07. Pilot study of a home-based aerobic exercise program for sedentary cancer survivors treated with hematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00520-022-06822-z

    DOI

    http://dx.doi.org/10.1007/s00520-022-06822-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1144911921

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35066668


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    25 schema:description PurposeDecline in physical function in the early stage after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a major challenge. Exercise tolerance tests, such as the 6-min walk test, are useful markers for predicting exercise tolerance and various other traits, including cardiometabolic risk and non-relapse mortality. This retrospective cohort study aimed to investigate and identify predictors of recovery of exercise tolerance in the early stage after allo-HSCT.MethodsNinety-eight patients were classified into recovery and non-recovery groups according to the median 6-min walk distance (6MWD) at discharge.ResultsLogistic regression analysis revealed that pre-post change in knee extensor strength (ΔKES) and hematopoietic cell transplantation comorbidity index were useful predictors of recovery of exercise tolerance at discharge and moderate predictors of 6MWD recovery in the early post-transplant period. Receiver operating characteristic analysis showed that pre-transplant ΔKES was an accurate predictor of 6MWD recovery in the early post-transplant period. The cutoff point for ΔKES calculated using the Youden index was − 1.17 Nm/kg.ConclusionsThe results of this study emphasize the importance of the need for programs designed to prevent muscle weakness in the early period after allo-HSCT. The results from markers of recovery of exercise tolerance are promising and can be used for patient education in rehabilitation programs after allo-HSCT.
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