Ontology type: schema:ScholarlyArticle
2019-01-04
AUTHORSE. A. Underwood, K. J. Jerzak, G. Lebovic, P. A. Rochon, C. Elser, K. I. Pritchard, M. C. Tierney
ABSTRACTPURPOSE: Evidence suggests endocrine therapy (ET) for breast cancer (BC) has adverse cognitive effects, but its specific effects on older women are unknown. This is despite the fact that older women are at increased risk of both breast cancer (BC) and cognitive decline relative to younger women. This study prospectively examined the cognitive effects of ET in a cohort of older BC patients. Our primary outcome measure was change in verbal memory, the cognitive domain most consistently affected by estrogen deprivation. METHODS: Forty-two chemotherapy-naïve women age 60+, without dementia and recently diagnosed with hormone receptor-positive BC, completed neuropsychological tests at the time of ET initiation and after 1 year of treatment. Change in age-standardized verbal memory performance was examined using paired t tests. To assess a broader range of potential cognitive effects, we also examined changes in visual memory, processing speed, frontal executive function, and perceptual reasoning. RESULTS: Participants exhibited significant decline from baseline to 1 year in verbal memory (p = 0.01). This decline was small to moderate in effect size (d = - 0.40). Performance on other domains did not change significantly over the year (all p > 0.05). CONCLUSIONS: Our findings suggest potentially detrimental effects of ET on verbal memory in older women after just 1 year of treatment. Given that ET is prescribed for courses of 5 to 10 years, additional studies examining longer-term effects of treatment in older women are critical. More... »
PAGES1-9
http://scigraph.springernature.com/pub.10.1007/s00520-018-4603-5
DOIhttp://dx.doi.org/10.1007/s00520-018-4603-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111099731
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30610433
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Psychology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Psychology and Cognitive Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Toronto",
"id": "https://www.grid.ac/institutes/grid.17063.33",
"name": [
"Primary Care Research Unit, Department of Family and Community Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Suite E349, Toronto, ON, Canada",
"Sunnybrook Research Institute, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Underwood",
"givenName": "E. A.",
"id": "sg:person.014124136742.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014124136742.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sunnybrook Health Science Centre",
"id": "https://www.grid.ac/institutes/grid.413104.3",
"name": [
"Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Jerzak",
"givenName": "K. J.",
"id": "sg:person.01201267630.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201267630.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "St. Michael's Hospital",
"id": "https://www.grid.ac/institutes/grid.415502.7",
"name": [
"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada",
"Applied Health Research Centre, St. Michael\u2019s Hospital, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Lebovic",
"givenName": "G.",
"id": "sg:person.01323214052.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323214052.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Women's College Hospital",
"id": "https://www.grid.ac/institutes/grid.417199.3",
"name": [
"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada",
"Department of Medicine, University of Toronto, Toronto, ON, Canada",
"Women\u2019s College Research Institute, Women\u2019s College Hospital, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Rochon",
"givenName": "P. A.",
"id": "sg:person.01005772611.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005772611.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sinai Health System",
"id": "https://www.grid.ac/institutes/grid.492573.e",
"name": [
"Department of Medicine, University of Toronto, Toronto, ON, Canada",
"Princess Margaret Hospital Cancer Centre, Toronto, ON, Canada",
"Sinai Health System, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Elser",
"givenName": "C.",
"id": "sg:person.01170205740.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170205740.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Toronto",
"id": "https://www.grid.ac/institutes/grid.17063.33",
"name": [
"Sunnybrook Research Institute, Toronto, ON, Canada",
"Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada",
"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada",
"Department of Medicine, University of Toronto, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Pritchard",
"givenName": "K. I.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Toronto",
"id": "https://www.grid.ac/institutes/grid.17063.33",
"name": [
"Department of Family & Community Medicine, University of Toronto, Toronto, ON, Canada",
"Primary Care Research Unit, Department of Family and Community Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Suite E349, Toronto, ON, Canada",
"Sunnybrook Research Institute, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Tierney",
"givenName": "M. C.",
"id": "sg:person.01341010632.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341010632.25"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/pon.3799",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000158645"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pon.3799",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000158645"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1037/1040-3590.7.1.80",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000989907"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.breast.2010.03.025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001675508"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1037/1040-3590.8.2.145",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002547610"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2013-1808",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004760566"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/17455057.3.2.173",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006616089"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/17455057.3.2.173",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006616089"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/00207454.2010.542842",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007570204"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/hbeh.2002.1770",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013428421"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.43.0116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019055846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.21.3553",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019393498"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejon.2011.07.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020147371"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clbc.2013.10.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020153517"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-319-19425-7_4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020949150",
"https://doi.org/10.1007/978-3-319-19425-7_4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/13825580902825220",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025461724"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2014.56.1662",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026897522"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djr257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027589075"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0306-4530(92)90007-t",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028832374"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0306-4530(92)90007-t",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028832374"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ctrv.2014.03.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029514785"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.285.11.1489",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032714420"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neubiorev.2016.03.024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036330096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/gme.0b013e318148b28b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041486475"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/gme.0b013e318148b28b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041486475"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2013.54.2258",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043023679"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-010-0756-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044286632",
"https://doi.org/10.1007/s10549-010-0756-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-010-0756-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044286632",
"https://doi.org/10.1007/s10549-010-0756-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pon.1453",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046873594"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2014.55.1259",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047180001"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0306-4530(03)00053-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053487033"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0306-4530(03)00053-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053487033"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/arclin/9.4.303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059400938"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000163773.21794.0b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000163773.21794.0b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000163773.21794.0b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.52.2.231",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064377111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.52.2.231",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064377111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.52.2.231",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064377111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.54.3.599",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064378338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1503/cjs.006211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067426016"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1503/cjs.006211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067426016"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3233/jad-2010-100516",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078240096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jop.2017.026286",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099657233"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-017-4627-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099730398",
"https://doi.org/10.1007/s10549-017-4627-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-017-4627-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099730398",
"https://doi.org/10.1007/s10549-017-4627-4"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-01-04",
"datePublishedReg": "2019-01-04",
"description": "PURPOSE: Evidence suggests endocrine therapy (ET) for breast cancer (BC) has adverse cognitive effects, but its specific effects on older women are unknown. This is despite the fact that older women are at increased risk of both breast cancer (BC) and cognitive decline relative to younger women. This study prospectively examined the cognitive effects of ET in a cohort of older BC patients. Our primary outcome measure was change in verbal memory, the cognitive domain most consistently affected by estrogen deprivation.\nMETHODS: Forty-two chemotherapy-na\u00efve women age 60+, without dementia and recently diagnosed with hormone receptor-positive BC, completed neuropsychological tests at the time of ET initiation and after 1\u00a0year of treatment. Change in age-standardized verbal memory performance was examined using paired t tests. To assess a broader range of potential cognitive effects, we also examined changes in visual memory, processing speed, frontal executive function, and perceptual reasoning.\nRESULTS: Participants exhibited significant decline from baseline to 1\u00a0year in verbal memory (p\u2009=\u00a00.01). This decline was small to moderate in effect size (d\u2009=\u2009-\u20090.40). Performance on other domains did not change significantly over the year (all p\u2009>\u20090.05).\nCONCLUSIONS: Our findings suggest potentially detrimental effects of ET on verbal memory in older women after just 1\u00a0year of treatment. Given that ET is prescribed for courses of 5 to 10\u00a0years, additional studies examining longer-term effects of treatment in older women are critical.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00520-018-4603-5",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1103473",
"issn": [
"0941-4355",
"1433-7339"
],
"name": "Supportive Care in Cancer",
"type": "Periodical"
}
],
"name": "Cognitive effects of adjuvant endocrine therapy in older women treated for early-stage breast cancer: a 1-year longitudinal study",
"pagination": "1-9",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"945741cc3fae74275dc40c2c49c7aabf3d0ea5cf5753c54645f6f6a5c8e421f5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30610433"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9302957"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00520-018-4603-5"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111099731"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00520-018-4603-5",
"https://app.dimensions.ai/details/publication/pub.1111099731"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T08:35",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000311_0000000311/records_55484_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs00520-018-4603-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00520-018-4603-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00520-018-4603-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00520-018-4603-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00520-018-4603-5'
This table displays all metadata directly associated to this object as RDF triples.
231 TRIPLES
21 PREDICATES
60 URIs
18 LITERALS
7 BLANK NODES