Patient perspectives on ipilimumab across the melanoma treatment trajectory View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-01

AUTHORS

Elyse Shuk, Alexander N. Shoushtari, Jason Luke, Michael A. Postow, Maggie Callahan, James J. Harding, Katherine G. Roth, Marisa Flavin, Adrian Granobles, Jana Christian, Geoffrey Gold, Maria Schoenhammer, Mallorie Gordon, Nicholas Cimaglia, Robert Dyson, Noah Goodman-Davis, Marta N. Colgan, Itisha S. Jefferson, Rodrigo Munhoz, Sandra D’Angelo, Jedd Wolchok, Paul Chapman, Ping Chi, Richard D. Carvajal, Jennifer L. Hay

ABSTRACT

PurposeIpilimumab was the first FDA-approved agent for advanced melanoma to improve survival and represents a paradigm shift in melanoma and cancer treatment. Its unique toxicity profile and kinetics of treatment response raise novel patient education challenges. We assessed patient perceptions of ipilimumab therapy across the treatment trajectory.MethodsFour patient cohorts were assessed at different time points relative to treatment initiation: (1) prior to initiation of ipilimumab (n = 10), (2) at weeks 10–12 before restaging studies (n = 11), (3) at week 12 following restaging studies indicating progression of disease (n = 10), and (4) at week 12 following restaging studies indicating either a radiographic response or disease stability (n = 10). Patients participated in a semistructured qualitative interview to assess their experiences with ipilimumab. Quality of life was assessed via the Functional Assessment of Cancer Therapy-General and its Melanoma-specific module.ResultsPerceived quality of life was comparable across cohorts, and a majority of the sample understood side effects from ipilimumab and the potential for a delayed treatment response. Patients without progression of disease following restaging studies at week 12 held more positive views regarding ipilimumab compared to patients who had progressed.ConclusionPatients generally regarded ipilimumab positively despite the risk of unique toxicities and potential for delayed therapeutic responses; however, those with progression expressed uncertainty regarding whether taking ipilimumab was worthwhile. Physician communication practices and patient education regarding realistic expectations for therapeutic benefit as well as unique toxicities associated with ipilimumab should be developed so that patients can better understand the possible outcomes from treatment. More... »

PAGES

2155-2167

Journal

TITLE

Supportive Care in Cancer

ISSUE

7

VOLUME

25

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00520-017-3621-z

DOI

http://dx.doi.org/10.1007/s00520-017-3621-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084022444

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28247127


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    "description": "PurposeIpilimumab was the first FDA-approved agent for advanced melanoma to improve survival and represents a paradigm shift in melanoma and cancer treatment. Its unique toxicity profile and kinetics of treatment response raise novel patient education challenges. We assessed patient perceptions of ipilimumab therapy across the treatment trajectory.MethodsFour patient cohorts were assessed at different time points relative to treatment initiation: (1) prior to initiation of ipilimumab (n\u00a0=\u00a010), (2) at weeks 10\u201312 before restaging studies (n\u00a0=\u00a011), (3) at week 12 following restaging studies indicating progression of disease (n\u00a0=\u00a010), and (4) at week 12 following restaging studies indicating either a radiographic response or disease stability (n\u00a0=\u00a010). Patients participated in a semistructured qualitative interview to assess their experiences with ipilimumab. Quality of life was assessed via the Functional Assessment of Cancer Therapy-General and its Melanoma-specific module.ResultsPerceived quality of life was comparable across cohorts, and a majority of the sample understood side effects from ipilimumab and the potential for a delayed treatment response. Patients without progression of disease following restaging studies at week 12 held more positive views regarding ipilimumab compared to patients who had progressed.ConclusionPatients generally regarded ipilimumab positively despite the risk of unique toxicities and potential for delayed therapeutic responses; however, those with progression expressed uncertainty regarding whether taking ipilimumab was worthwhile. Physician communication practices and patient education regarding realistic expectations for therapeutic benefit as well as unique toxicities associated with ipilimumab should be developed so that patients can better understand the possible outcomes from treatment.", 
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21 schema:description PurposeIpilimumab was the first FDA-approved agent for advanced melanoma to improve survival and represents a paradigm shift in melanoma and cancer treatment. Its unique toxicity profile and kinetics of treatment response raise novel patient education challenges. We assessed patient perceptions of ipilimumab therapy across the treatment trajectory.MethodsFour patient cohorts were assessed at different time points relative to treatment initiation: (1) prior to initiation of ipilimumab (n = 10), (2) at weeks 10–12 before restaging studies (n = 11), (3) at week 12 following restaging studies indicating progression of disease (n = 10), and (4) at week 12 following restaging studies indicating either a radiographic response or disease stability (n = 10). Patients participated in a semistructured qualitative interview to assess their experiences with ipilimumab. Quality of life was assessed via the Functional Assessment of Cancer Therapy-General and its Melanoma-specific module.ResultsPerceived quality of life was comparable across cohorts, and a majority of the sample understood side effects from ipilimumab and the potential for a delayed treatment response. Patients without progression of disease following restaging studies at week 12 held more positive views regarding ipilimumab compared to patients who had progressed.ConclusionPatients generally regarded ipilimumab positively despite the risk of unique toxicities and potential for delayed therapeutic responses; however, those with progression expressed uncertainty regarding whether taking ipilimumab was worthwhile. Physician communication practices and patient education regarding realistic expectations for therapeutic benefit as well as unique toxicities associated with ipilimumab should be developed so that patients can better understand the possible outcomes from treatment.
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