Hope, optimism and survival in a randomised trial of chemotherapy for metastatic colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-01

AUTHORS

Penelope E. Schofield, M. R. Stockler, D. Zannino, N. C. Tebbutt, T. J. Price, R. J. Simes, N. Wong, N. Pavlakis, D. Ransom, E. Moylan, C. Underhill, D. Wyld, I. Burns, R. Ward, N. Wilcken, M. Jefford

ABSTRACT

PURPOSE: Psychological responses to cancer are widely believed to affect survival. We investigated associations between hope, optimism, anxiety, depression, health utility and survival in patients starting first-line chemotherapy for metastatic colorectal cancer. METHODS: Four hundred twenty-nine subjects with metastatic colorectal cancer in a randomised controlled trial of chemotherapy completed baseline questionnaires assessing the following: hopefulness, optimism, anxiety and depression and health utility. Hazard ratios (HRs) and P values were calculated with Cox models for overall survival (OS) and progression-free survival (PFS) in univariable and multivariable analyses. RESULTS: Median follow-up was 31 months. Univariable analyses showed that OS was associated negatively with depression (HR 2.04, P < 0.001) and positively with health utility (HR 0.56, P < 0.001) and hopefulness (HR 0.75, P = 0.013). In multivariable analysis, OS was also associated negatively with depression (HR 1.72, P < 0.001) and positively with health utility (HR 0.73, P = 0.014), but not with optimism, anxiety or hopefulness. PFS was not associated with hope, optimism, anxiety or depression in any analyses. CONCLUSIONS: Depression and health utility, but not optimism, hope or anxiety, were associated with survival after controlling for known prognostic factors in patients with advanced colorectal cancer. Further research is required to understand the nature of the relationship between depression and survival. If a causal mechanism is identified, this may lead to interventional possibilities. More... »

PAGES

401-408

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00520-015-2792-8

DOI

http://dx.doi.org/10.1007/s00520-015-2792-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019430909

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26093975


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