Topische Schmerztherapie bei oraler Mukositis View Full Text


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Article Info

DATE

2013-05-19

AUTHORS

H. Bornemann-Cimenti, S.K. Kobald, I.S. Szilagyi, A. Sandner-Kiesling

ABSTRACT

BackgroundThe pain provoked by mucositis is often described as the most excruciating symptom of cancer treatment. It often causes reduced ingestion, malnutrition, and sometimes postponement or withdrawal of the therapy. For health care providers, adequate pain treatment is a major challenge. The aim of this article is to present an overview of studies on the topical treatment of mucositis pain.MethodsA systematic search was performed in PubMed with the keywords “mucositis” “pain” and “topical” or “local”. In addition, reference lists and relevant websites were scanned for appropriate literature.ResultsA total of 47 articles were included. There is only scarce evidence for the topical treatment of mucositis pain. The most convincing studies tested opioids, corticoids and benzydamine. For the other substances, too few studies were performed, the results were contradictory, or the study quality was low.ConclusionBased on the information gathered in this systematic search of the literature, topical treatment of mucositis pain today is based on empiricism and not on scientific evidence. More... »

PAGES

253-262

References to SciGraph publications

  • 2000-01. Efficacy of treatment to relieve mucositis-induced discomfort in SUPPORTIVE CARE IN CANCER
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  • 1998-10-01. Effect of topical oral G-CSF on oral mucositis: a randomised placebo-controlled trial in BONE MARROW TRANSPLANTATION
  • 1978-02. Recurrent oral ulceration. A double-blind comparison of treatment with betamethasone valerate aerosol and placebo in BRITISH DENTAL JOURNAL
  • 2008-01. Efficacy of a Mucoadhesive Patch Compared with an Oral Solution for Treatment of Aphthous Stomatitis in DRUGS IN R&D
  • 2003-04-01. A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • 2006-01-16. Reliability and validity of a patient self-administered daily questionnaire to assess impact of oral mucositis (OM) on pain and daily functioning in patients undergoing autologous hematopoietic stem cell transplantation (HSCT) in BONE MARROW TRANSPLANTATION
  • 2009-05-06. A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial in TRIALS
  • 2006-11-28. Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis in SUPPORTIVE CARE IN CANCER
  • 2004-01-29. Tolerability and effects of two formulations of oral transmucosal fentanyl citrate (OTFC; ACTIQ) in patients with radiation-induced oral mucositis in SUPPORTIVE CARE IN CANCER
  • 2005-08. Topische Applikation von Morphingel bei entzündlichen Haut- und Schleimhautläsionen in DER SCHMERZ
  • 1983-03-19. A controlled clinical trial of the efficacy of topically applied fluocinonide in the treatment of recurrent aphthous ulceration in BRITISH DENTAL JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00482-013-1318-x

    DOI

    http://dx.doi.org/10.1007/s00482-013-1318-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014026651

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23685992


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