Pregabalin und postoperative Hyperalgesie View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12-23

AUTHORS

A.J. Lederer, H. Bornemann-Cimenti, M. Wejbora, C. Kern-Pirsch, K. Michaeli, A. Sandner-Kiesling

ABSTRACT

Numerous studies support the theory that pregabalin causes an antihyperalgesic effect, which could be potentially beneficial in a perioperative setting. By binding to calcium channels pregabalin reduces the release of excitatory neurotransmitters and therefore inhibits central sensitization. Animal studies clearly demonstrated the antihyperalgesic potency of pregabalin but human experiments are, however, inconclusive. Clinical studies with quantitative sensory testing have not yet been published.Although strongly supported by theoretical considerations the routine preoperative application of pregabalin for the prevention of hyperalgesia cannot be recommended due to the lack of clinical studies. Future studies should incorporate secondary hyperalgesia and allodynia as primary parameters. More... »

PAGES

12-18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00482-010-1008-x

DOI

http://dx.doi.org/10.1007/s00482-010-1008-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012729740

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21181417


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