Evaluation of pediatric nephropathies by a computerized Urine Protein Expert System (UPES) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11

AUTHORS

Andreas Lun, Miroslav Ivandic, Friedrich Priem, Guido Filler, Martin Kirschstein, Jochen H. H. Ehrich, Walter G. Guder

ABSTRACT

A computerized Urine Protein Expert System (UPES) measuring creatinine, total protein, albumin, IgG, alpha(1)-microglobulin, alpha(2)-macroglobulin, and N-acetyl-beta-D-glucosaminidase, together with urine dipstick testing for granulocyte esterase and hemoglobin pseudoperoxidase, and measurement of serum creatinine had been found to be useful in adults for differentiating between renal disorders. The objective of this study was to investigate UPES for identifying the different types of proteinuria and their underlying prerenal, glomerular, tubular, and postrenal causes in 146 children characterized by routine and invasive nephrological investigations. UPES proved to be a useful tool in pediatric renal patients after refinements were implemented in the program. Comparing UPES with the pediatric nephrologist's interpretation of all available clinical and laboratory data, UPES diagnosed glomerulopathies in 46 (75%) of 61 patients. In a further 23% it suggested glomerular involvement by indicating either a disturbed glomerular permeability or increased excretion of albumin. Tubular proteinuria was correctly described by UPES in 23 (100%) patients with different tubulopathies. UPES revealed normal kidney function in all healthy children and all children with remission of renal disorders. Therefore, UPES can be regarded as a useful tool in the automated differentiation of renal diseases in children. More... »

PAGES

900-906

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004670050724

DOI

http://dx.doi.org/10.1007/s004670050724

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006440038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10603145


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