ABO-incompatible pediatric kidney transplantation in a single-center trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-01

AUTHORS

Toshiyuki Ohta, Hiroshi Kawaguchi, Motoshi Hattori, Kazuhiro Takahashi, Hiroyuki Nagafuchi, Yuko Akioka, Waichiro Mizushima, Nobuo Ishikawa, Kazanari Tanabe, Hiroshi Toma, Kota Takahashi, Kazuo Ota, Katsumi Ito

ABSTRACT

We have performed ten pediatric kidney transplantations from living-related ABO-incompatible donors. All patients underwent preoperative plasmapheresis with or without immunoadsorption to reduce isoagglutinin. Primary immunosuppression consisted of methylprednisolone, cyclosporin or tacrolimus, azathioprine, anti-lymphocyte globulin, and/or deoxyspergualin. At transplantation splenectomy was simultaneously performed in all patients. Median follow-up is 65 months (range 4–95 months). The patient and graft survival rates are 100% to date. Post-transplantation isoagglutinin titers did not increase more than 1:32, except for 1 patient, without uncontrollable vascular rejection episodes. Despite the heavy immunosuppressive regimen, cytomegalovirus infection occurred in only three patients, who were successfully treated with ganciclovir and cytomegalovirus high-titer gamma globulin. Our small series clearly shows that the preoperative reduction of isoagglutinin, splenectomy, and strict immunosuppressive therapy lead to successful long-term results in children. More... »

PAGES

1-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004670050001

DOI

http://dx.doi.org/10.1007/s004670050001

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040575324

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11094999


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