Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-06-06

AUTHORS

Ryoko Harada, Yuko Hamasaki, Yusuke Okuda, Riku Hamada, Kenji Ishikura

ABSTRACT

Although the concept of chronic kidney disease (CKD) in children is similar to that in adults, pediatric CKD has some peculiarities, and there is less evidence and many factors that are not clearly understood. The past decade has witnessed several additional registry and cohort studies of pediatric CKD and kidney failure. The most common underlying disease in pediatric CKD and kidney failure is congenital anomalies of the kidney and urinary tract (CAKUT), which is one of the major characteristics of CKD in children. The incidence/prevalence of CKD in children varies worldwide. Hypertension and proteinuria are independent risk factors for CKD progression; other factors that may affect CKD progression are primary disease, age, sex, racial/genetic factors, urological problems, low birth weight, and social background. Many studies based on registry data revealed that the risk factors for mortality among children with kidney failure who are receiving kidney replacement therapy are younger age, female sex, non-White race, non-CAKUT etiologies, anemia, hypoalbuminemia, and high estimated glomerular filtration rate at dialysis initiation. The evidence has contributed to clinical practice. The results of these registry-based studies are expected to lead to new improvements in pediatric CKD care. More... »

PAGES

1215-1229

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00467-021-05145-1

    DOI

    http://dx.doi.org/10.1007/s00467-021-05145-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1138645716

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34091754


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