Prophylactic rituximab administration in children with complicated nephrotic syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-09-30

AUTHORS

Mika Okutsu, Koichi Kamei, Mai Sato, Toru Kanamori, Kentaro Nishi, Sho Ishiwa, Masao Ogura, Mayumi Sako, Shuichi Ito, Kenji Ishikura

ABSTRACT

BackgroundRituximab is effective for maintaining remission in patients with complicated nephrotic syndrome, although a history of steroid-resistant nephrotic syndrome (SRNS) is a risk factor for early relapse. We investigated the efficacy of prophylactic rituximab treatment for maintaining remission after B cell recovery.MethodsPatients with complicated steroid-dependent or frequently relapsing nephrotic syndrome with history of SRNS who received a single dose of rituximab (375 mg/m2) and continued immunosuppressive agents were enrolled in this retrospective study. Patients were divided into two groups: a prophylaxis group, which received additional rituximab treatment at B cell recovery and a non-prophylaxis group. The relapse-free period from the last rituximab infusion (the second treatment in prophylaxis group and the first treatment in non-prophylaxis group) was compared between two groups using the Kaplan-Meier method, and risk factors for early relapse were calculated using multivariate analysis by Cox proportional hazards model.ResultsSixteen patients in the prophylaxis group and 45 in the non-prophylaxis group were enrolled. Fifty-percent relapse-free survival after the last rituximab treatment was 667 days in the former and 335 days in the latter (p = 0.001). Multivariate analysis showed that additional rituximab treatment was the only significant negative factor for early relapse, with a hazard ratio of 0.40 (p = 0.02). Fifty-percent relapse-free survival after B cell recovery was much longer in the prophylaxis group (954 vs. 205.5 days, p = 0.003).ConclusionsAdditional rituximab treatment at B cell recovery can maintain prolonged remission even after B cell recovery in patients with complicated nephrotic syndrome with history of SRNS. More... »

PAGES

611-619

References to SciGraph publications

  • 2017-06-29. Long-term outcome of childhood-onset complicated nephrotic syndrome after a multicenter, double-blind, randomized, placebo-controlled trial of rituximab in PEDIATRIC NEPHROLOGY
  • 2011-05-10. Maintenance therapy with mycophenolate mofetil after rituximab in pediatric patients with steroid-dependent nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2013-01-23. Long-term outcome of children treated with rituximab for idiopathic nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2013-05-23. Fulminant viral myocarditis after rituximab therapy in pediatric nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2012-12-05. Does rituximab induce hypogammaglobulinemia in patients with pediatric idiopathic nephrotic syndrome? in PEDIATRIC NEPHROLOGY
  • 2018-07-09. Rituximab modulates T- and B-lymphocyte subsets and urinary CD80 excretion in patients with steroid-dependent nephrotic syndrome in PEDIATRIC RESEARCH
  • 2012-09-05. Atypical Pneumocystis jiroveci pneumonia with multiple nodular granulomas after rituximab for refractory nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2018-08-14. Effect of different rituximab regimens on B cell depletion and time to relapse in children with steroid-dependent nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2009-09-01. Fatal pulmonary fibrosis after rituximab administration in PEDIATRIC NEPHROLOGY
  • 2012-12-28. Cyclosporine versus mycophenolate mofetil for maintenance of remission of steroid-dependent nephrotic syndrome after a single infusion of rituximab in EUROPEAN JOURNAL OF PEDIATRICS
  • 2015-09-04. Risk factors for relapse and long-term outcome in steroid-dependent nephrotic syndrome treated with rituximab in PEDIATRIC NEPHROLOGY
  • 2016-08-24. Predictors of relapse and long-term outcome in children with steroid-dependent nephrotic syndrome after rituximab treatment in CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00467-020-04771-5

    DOI

    http://dx.doi.org/10.1007/s00467-020-04771-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1131290293

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32995922


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunosuppressive Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nephrotic Syndrome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recurrence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rituximab", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Steroids", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
                "Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okutsu", 
            "givenName": "Mika", 
            "id": "sg:person.012205235451.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012205235451.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.63906.3a", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamei", 
            "givenName": "Koichi", 
            "id": "sg:person.01316365041.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316365041.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.63906.3a", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sato", 
            "givenName": "Mai", 
            "id": "sg:person.01060345462.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060345462.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
                "Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanamori", 
            "givenName": "Toru", 
            "id": "sg:person.07530365265.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07530365265.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.63906.3a", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishi", 
            "givenName": "Kentaro", 
            "id": "sg:person.010612274451.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010612274451.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatric Nephrology, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410818.4", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
                "Department of Pediatric Nephrology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishiwa", 
            "givenName": "Sho", 
            "id": "sg:person.015722404651.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015722404651.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.63906.3a", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogura", 
            "givenName": "Masao", 
            "id": "sg:person.01174574062.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174574062.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.63906.3a", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sako", 
            "givenName": "Mayumi", 
            "id": "sg:person.01032464245.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032464245.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Yokohama City University Hospital, Yokohama, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.470126.6", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
                "Department of Pediatrics, Yokohama City University Hospital, Yokohama, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ito", 
            "givenName": "Shuichi", 
            "id": "sg:person.012302533312.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012302533312.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410786.c", 
              "name": [
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan", 
                "Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishikura", 
            "givenName": "Kenji", 
            "id": "sg:person.01112735663.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112735663.13"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00467-013-2485-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039329871", 
              "https://doi.org/10.1007/s00467-013-2485-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41390-018-0088-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105391009", 
              "https://doi.org/10.1038/s41390-018-0088-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-009-1195-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028250994", 
              "https://doi.org/10.1007/s00467-009-1195-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-018-4052-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106150073", 
              "https://doi.org/10.1007/s00467-018-4052-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-012-2361-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017924951", 
              "https://doi.org/10.1007/s00467-012-2361-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-017-3718-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090306762", 
              "https://doi.org/10.1007/s00467-017-3718-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-012-2286-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009853115", 
              "https://doi.org/10.1007/s00467-012-2286-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-015-3197-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008249108", 
              "https://doi.org/10.1007/s00467-015-3197-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00431-012-1913-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045736439", 
              "https://doi.org/10.1007/s00431-012-1913-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-011-1886-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038755333", 
              "https://doi.org/10.1007/s00467-011-1886-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10157-016-1328-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021619576", 
              "https://doi.org/10.1007/s10157-016-1328-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-012-2406-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011349484", 
              "https://doi.org/10.1007/s00467-012-2406-3"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-09-30", 
        "datePublishedReg": "2020-09-30", 
        "description": "BackgroundRituximab is effective for maintaining remission in patients with complicated nephrotic syndrome, although a history of steroid-resistant nephrotic syndrome (SRNS) is a risk factor for early relapse. We investigated the efficacy of prophylactic rituximab treatment for maintaining remission after B cell recovery.MethodsPatients with complicated steroid-dependent or frequently relapsing nephrotic syndrome with history of SRNS who received a single dose of rituximab (375 mg/m2) and continued immunosuppressive agents were enrolled in this retrospective study. Patients were divided into two groups: a prophylaxis group, which received additional rituximab treatment at B cell recovery and a non-prophylaxis group. The relapse-free period from the last rituximab infusion (the second treatment in prophylaxis group and the first treatment in non-prophylaxis group) was compared between two groups using the Kaplan-Meier method, and risk factors for early relapse were calculated using multivariate analysis by Cox proportional hazards model.ResultsSixteen patients in the prophylaxis group and 45 in the non-prophylaxis group were enrolled. Fifty-percent relapse-free survival after the last rituximab treatment was 667 days in the former and 335 days in the latter (p = 0.001). Multivariate analysis showed that additional rituximab treatment was the\u00a0only significant negative factor for early relapse, with a hazard ratio of 0.40 (p = 0.02). Fifty-percent relapse-free survival after B cell recovery was much longer in the prophylaxis group (954 vs. 205.5 days, p = 0.003).ConclusionsAdditional rituximab treatment at B cell recovery can maintain prolonged remission even after B cell recovery in patients with complicated nephrotic syndrome with history of SRNS.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00467-020-04771-5", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1097267", 
            "issn": [
              "0931-041X", 
              "1432-198X"
            ], 
            "name": "Pediatric Nephrology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "36"
          }
        ], 
        "keywords": [
          "steroid-resistant nephrotic syndrome", 
          "B-cell recovery", 
          "complicated nephrotic syndrome", 
          "additional rituximab treatment", 
          "non-prophylaxis group", 
          "rituximab treatment", 
          "relapse-free survival", 
          "nephrotic syndrome", 
          "prophylaxis group", 
          "early relapse", 
          "risk factors", 
          "cell recovery", 
          "multivariate analysis", 
          "Cox proportional hazards model", 
          "last rituximab infusion", 
          "last rituximab treatment", 
          "Kaplan-Meier method", 
          "relapse-free period", 
          "proportional hazards model", 
          "rituximab infusion", 
          "ResultsSixteen patients", 
          "rituximab administration", 
          "prolonged remissions", 
          "hazard ratio", 
          "immunosuppressive agents", 
          "retrospective study", 
          "single dose", 
          "significant negative factor", 
          "hazards model", 
          "patients", 
          "syndrome", 
          "remission", 
          "relapse", 
          "treatment", 
          "survival", 
          "group", 
          "days", 
          "BackgroundRituximab", 
          "MethodsPatients", 
          "rituximab", 
          "infusion", 
          "recovery", 
          "factors", 
          "dose", 
          "administration", 
          "history", 
          "efficacy", 
          "children", 
          "negative factors", 
          "agents", 
          "period", 
          "study", 
          "analysis", 
          "ratio", 
          "method", 
          "model"
        ], 
        "name": "Prophylactic rituximab administration in children with complicated nephrotic syndrome", 
        "pagination": "611-619", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1131290293"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00467-020-04771-5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "32995922"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00467-020-04771-5", 
          "https://app.dimensions.ai/details/publication/pub.1131290293"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:23", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_843.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00467-020-04771-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00467-020-04771-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00467-020-04771-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00467-020-04771-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00467-020-04771-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    273 TRIPLES      22 PREDICATES      101 URIs      81 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00467-020-04771-5 schema:about N08e4358832ac4ed7bb20c2ca7ee3c12c
    2 N158739a21f9b44bcb05cca8926b7766c
    3 N2894a0d8fc424148b3043c82771c883b
    4 N2b4dbead509940229676fb387e3148db
    5 N813f7c71fa1f4ba6a69747518622ea95
    6 N8165cff3ebe24816bd6719192f2492bc
    7 N82a96311142448e191217b8321d50930
    8 anzsrc-for:11
    9 anzsrc-for:1103
    10 schema:author N274e7337e281474aa76c575004a00bb4
    11 schema:citation sg:pub.10.1007/s00431-012-1913-3
    12 sg:pub.10.1007/s00467-009-1195-9
    13 sg:pub.10.1007/s00467-011-1886-x
    14 sg:pub.10.1007/s00467-012-2286-6
    15 sg:pub.10.1007/s00467-012-2361-z
    16 sg:pub.10.1007/s00467-012-2406-3
    17 sg:pub.10.1007/s00467-013-2485-9
    18 sg:pub.10.1007/s00467-015-3197-0
    19 sg:pub.10.1007/s00467-017-3718-0
    20 sg:pub.10.1007/s00467-018-4052-x
    21 sg:pub.10.1007/s10157-016-1328-y
    22 sg:pub.10.1038/s41390-018-0088-7
    23 schema:datePublished 2020-09-30
    24 schema:datePublishedReg 2020-09-30
    25 schema:description BackgroundRituximab is effective for maintaining remission in patients with complicated nephrotic syndrome, although a history of steroid-resistant nephrotic syndrome (SRNS) is a risk factor for early relapse. We investigated the efficacy of prophylactic rituximab treatment for maintaining remission after B cell recovery.MethodsPatients with complicated steroid-dependent or frequently relapsing nephrotic syndrome with history of SRNS who received a single dose of rituximab (375 mg/m2) and continued immunosuppressive agents were enrolled in this retrospective study. Patients were divided into two groups: a prophylaxis group, which received additional rituximab treatment at B cell recovery and a non-prophylaxis group. The relapse-free period from the last rituximab infusion (the second treatment in prophylaxis group and the first treatment in non-prophylaxis group) was compared between two groups using the Kaplan-Meier method, and risk factors for early relapse were calculated using multivariate analysis by Cox proportional hazards model.ResultsSixteen patients in the prophylaxis group and 45 in the non-prophylaxis group were enrolled. Fifty-percent relapse-free survival after the last rituximab treatment was 667 days in the former and 335 days in the latter (p = 0.001). Multivariate analysis showed that additional rituximab treatment was the only significant negative factor for early relapse, with a hazard ratio of 0.40 (p = 0.02). Fifty-percent relapse-free survival after B cell recovery was much longer in the prophylaxis group (954 vs. 205.5 days, p = 0.003).ConclusionsAdditional rituximab treatment at B cell recovery can maintain prolonged remission even after B cell recovery in patients with complicated nephrotic syndrome with history of SRNS.
    26 schema:genre article
    27 schema:inLanguage en
    28 schema:isAccessibleForFree false
    29 schema:isPartOf N30d7fd1568914b31bf3bfd8d29fa54fd
    30 N817a0f8433b94d20a6fae635cfcb9cc6
    31 sg:journal.1097267
    32 schema:keywords B-cell recovery
    33 BackgroundRituximab
    34 Cox proportional hazards model
    35 Kaplan-Meier method
    36 MethodsPatients
    37 ResultsSixteen patients
    38 additional rituximab treatment
    39 administration
    40 agents
    41 analysis
    42 cell recovery
    43 children
    44 complicated nephrotic syndrome
    45 days
    46 dose
    47 early relapse
    48 efficacy
    49 factors
    50 group
    51 hazard ratio
    52 hazards model
    53 history
    54 immunosuppressive agents
    55 infusion
    56 last rituximab infusion
    57 last rituximab treatment
    58 method
    59 model
    60 multivariate analysis
    61 negative factors
    62 nephrotic syndrome
    63 non-prophylaxis group
    64 patients
    65 period
    66 prolonged remissions
    67 prophylaxis group
    68 proportional hazards model
    69 ratio
    70 recovery
    71 relapse
    72 relapse-free period
    73 relapse-free survival
    74 remission
    75 retrospective study
    76 risk factors
    77 rituximab
    78 rituximab administration
    79 rituximab infusion
    80 rituximab treatment
    81 significant negative factor
    82 single dose
    83 steroid-resistant nephrotic syndrome
    84 study
    85 survival
    86 syndrome
    87 treatment
    88 schema:name Prophylactic rituximab administration in children with complicated nephrotic syndrome
    89 schema:pagination 611-619
    90 schema:productId N571d04df40a649789e105d32d719f46c
    91 N5e83a62d67574d72ab19ce803ddd2d12
    92 Nf12777d850ac40e7bd0f2b64d152df12
    93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131290293
    94 https://doi.org/10.1007/s00467-020-04771-5
    95 schema:sdDatePublished 2022-05-10T10:23
    96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    97 schema:sdPublisher Nf4e3b8f660f6433f85f9fee3f024cd76
    98 schema:url https://doi.org/10.1007/s00467-020-04771-5
    99 sgo:license sg:explorer/license/
    100 sgo:sdDataset articles
    101 rdf:type schema:ScholarlyArticle
    102 N02a4998342f64383a0a34c2b247c4316 rdf:first sg:person.01032464245.22
    103 rdf:rest N77ccf411bc0c4ce28fd032b75c6b8d0d
    104 N08e4358832ac4ed7bb20c2ca7ee3c12c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Rituximab
    106 rdf:type schema:DefinedTerm
    107 N158739a21f9b44bcb05cca8926b7766c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Humans
    109 rdf:type schema:DefinedTerm
    110 N1f4663adacf648be831730ee5554114e rdf:first sg:person.010612274451.16
    111 rdf:rest N8a8aad35f44b4a37962e9a559913881b
    112 N274e7337e281474aa76c575004a00bb4 rdf:first sg:person.012205235451.53
    113 rdf:rest Nda3cc6e47a98495f90e2f1739b081e4b
    114 N2894a0d8fc424148b3043c82771c883b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Nephrotic Syndrome
    116 rdf:type schema:DefinedTerm
    117 N2b4dbead509940229676fb387e3148db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Immunosuppressive Agents
    119 rdf:type schema:DefinedTerm
    120 N30d7fd1568914b31bf3bfd8d29fa54fd schema:issueNumber 3
    121 rdf:type schema:PublicationIssue
    122 N571d04df40a649789e105d32d719f46c schema:name dimensions_id
    123 schema:value pub.1131290293
    124 rdf:type schema:PropertyValue
    125 N5e83a62d67574d72ab19ce803ddd2d12 schema:name doi
    126 schema:value 10.1007/s00467-020-04771-5
    127 rdf:type schema:PropertyValue
    128 N5f0f24ecb0fb4abe9a3558cc8f6de141 rdf:first sg:person.01112735663.13
    129 rdf:rest rdf:nil
    130 N5f189ac7ae8046b8a8c050b73b4cc741 rdf:first sg:person.01174574062.16
    131 rdf:rest N02a4998342f64383a0a34c2b247c4316
    132 N77ccf411bc0c4ce28fd032b75c6b8d0d rdf:first sg:person.012302533312.63
    133 rdf:rest N5f0f24ecb0fb4abe9a3558cc8f6de141
    134 N813f7c71fa1f4ba6a69747518622ea95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Recurrence
    136 rdf:type schema:DefinedTerm
    137 N8165cff3ebe24816bd6719192f2492bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Steroids
    139 rdf:type schema:DefinedTerm
    140 N817a0f8433b94d20a6fae635cfcb9cc6 schema:volumeNumber 36
    141 rdf:type schema:PublicationVolume
    142 N82a96311142448e191217b8321d50930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Retrospective Studies
    144 rdf:type schema:DefinedTerm
    145 N8a8aad35f44b4a37962e9a559913881b rdf:first sg:person.015722404651.24
    146 rdf:rest N5f189ac7ae8046b8a8c050b73b4cc741
    147 Nbe0c7df3e7ce423ab00b395447a753eb rdf:first sg:person.07530365265.08
    148 rdf:rest N1f4663adacf648be831730ee5554114e
    149 Nd41469bd46ad4b6a9f7e615b082f3b96 rdf:first sg:person.01060345462.48
    150 rdf:rest Nbe0c7df3e7ce423ab00b395447a753eb
    151 Nda3cc6e47a98495f90e2f1739b081e4b rdf:first sg:person.01316365041.17
    152 rdf:rest Nd41469bd46ad4b6a9f7e615b082f3b96
    153 Nf12777d850ac40e7bd0f2b64d152df12 schema:name pubmed_id
    154 schema:value 32995922
    155 rdf:type schema:PropertyValue
    156 Nf4e3b8f660f6433f85f9fee3f024cd76 schema:name Springer Nature - SN SciGraph project
    157 rdf:type schema:Organization
    158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    159 schema:name Medical and Health Sciences
    160 rdf:type schema:DefinedTerm
    161 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    162 schema:name Clinical Sciences
    163 rdf:type schema:DefinedTerm
    164 sg:journal.1097267 schema:issn 0931-041X
    165 1432-198X
    166 schema:name Pediatric Nephrology
    167 schema:publisher Springer Nature
    168 rdf:type schema:Periodical
    169 sg:person.01032464245.22 schema:affiliation grid-institutes:grid.63906.3a
    170 schema:familyName Sako
    171 schema:givenName Mayumi
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032464245.22
    173 rdf:type schema:Person
    174 sg:person.01060345462.48 schema:affiliation grid-institutes:grid.63906.3a
    175 schema:familyName Sato
    176 schema:givenName Mai
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060345462.48
    178 rdf:type schema:Person
    179 sg:person.010612274451.16 schema:affiliation grid-institutes:grid.63906.3a
    180 schema:familyName Nishi
    181 schema:givenName Kentaro
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010612274451.16
    183 rdf:type schema:Person
    184 sg:person.01112735663.13 schema:affiliation grid-institutes:grid.410786.c
    185 schema:familyName Ishikura
    186 schema:givenName Kenji
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112735663.13
    188 rdf:type schema:Person
    189 sg:person.01174574062.16 schema:affiliation grid-institutes:grid.63906.3a
    190 schema:familyName Ogura
    191 schema:givenName Masao
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174574062.16
    193 rdf:type schema:Person
    194 sg:person.012205235451.53 schema:affiliation grid-institutes:grid.265073.5
    195 schema:familyName Okutsu
    196 schema:givenName Mika
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012205235451.53
    198 rdf:type schema:Person
    199 sg:person.012302533312.63 schema:affiliation grid-institutes:grid.470126.6
    200 schema:familyName Ito
    201 schema:givenName Shuichi
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012302533312.63
    203 rdf:type schema:Person
    204 sg:person.01316365041.17 schema:affiliation grid-institutes:grid.63906.3a
    205 schema:familyName Kamei
    206 schema:givenName Koichi
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316365041.17
    208 rdf:type schema:Person
    209 sg:person.015722404651.24 schema:affiliation grid-institutes:grid.410818.4
    210 schema:familyName Ishiwa
    211 schema:givenName Sho
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015722404651.24
    213 rdf:type schema:Person
    214 sg:person.07530365265.08 schema:affiliation grid-institutes:grid.265073.5
    215 schema:familyName Kanamori
    216 schema:givenName Toru
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07530365265.08
    218 rdf:type schema:Person
    219 sg:pub.10.1007/s00431-012-1913-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045736439
    220 https://doi.org/10.1007/s00431-012-1913-3
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1007/s00467-009-1195-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028250994
    223 https://doi.org/10.1007/s00467-009-1195-9
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/s00467-011-1886-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038755333
    226 https://doi.org/10.1007/s00467-011-1886-x
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/s00467-012-2286-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009853115
    229 https://doi.org/10.1007/s00467-012-2286-6
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s00467-012-2361-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1017924951
    232 https://doi.org/10.1007/s00467-012-2361-z
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s00467-012-2406-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011349484
    235 https://doi.org/10.1007/s00467-012-2406-3
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s00467-013-2485-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039329871
    238 https://doi.org/10.1007/s00467-013-2485-9
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1007/s00467-015-3197-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008249108
    241 https://doi.org/10.1007/s00467-015-3197-0
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/s00467-017-3718-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090306762
    244 https://doi.org/10.1007/s00467-017-3718-0
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/s00467-018-4052-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1106150073
    247 https://doi.org/10.1007/s00467-018-4052-x
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s10157-016-1328-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1021619576
    250 https://doi.org/10.1007/s10157-016-1328-y
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/s41390-018-0088-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105391009
    253 https://doi.org/10.1038/s41390-018-0088-7
    254 rdf:type schema:CreativeWork
    255 grid-institutes:grid.265073.5 schema:alternateName Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan
    256 schema:name Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan
    257 Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan
    258 rdf:type schema:Organization
    259 grid-institutes:grid.410786.c schema:alternateName Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    260 schema:name Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    261 Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan
    262 rdf:type schema:Organization
    263 grid-institutes:grid.410818.4 schema:alternateName Department of Pediatric Nephrology, Tokyo Women’s Medical University, Tokyo, Japan
    264 schema:name Department of Pediatric Nephrology, Tokyo Women’s Medical University, Tokyo, Japan
    265 Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan
    266 rdf:type schema:Organization
    267 grid-institutes:grid.470126.6 schema:alternateName Department of Pediatrics, Yokohama City University Hospital, Yokohama, Kanagawa, Japan
    268 schema:name Department of Pediatrics, Yokohama City University Hospital, Yokohama, Kanagawa, Japan
    269 Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan
    270 rdf:type schema:Organization
    271 grid-institutes:grid.63906.3a schema:alternateName Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan
    272 schema:name Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan
    273 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...