Steroid therapy in children with IgA nephropathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-18

AUTHORS

Alexandra Cambier, Olivia Boyer, Georges Deschenes, James Gleeson, Anne Couderc, Julien Hogan, Thomas Robert

ABSTRACT

IgA nephropathy (IgAN) is one the most common primary glomerulonephritis in children and adolescents worldwide, with 20% of children developing end-stage kidney disease (ESKD) within 20 years of diagnosis. There is a need for treatment guidelines, especially for steroids in children with primary IgAN, since the STOP-IgA trial casts doubts on the use of steroids in adults with intermediate risk. Pediatricians are prone to prescribe steroids in addition to renin-angiotensin system blockade (RASB) when proteinuria is > 0.5 g/l, eGFR deteriorates < 70 ml/min/1.73 m2, or when a biopsy sample shows glomerular inflammation. Lack of randomized controlled trials (RCTs) in children with IgAN has led to an absence of consensus on the use of immunosuppressive agents in the treatment of progressive IgAN. This literature review evaluates the available evidence on steroid treatment in children with IgAN. More... »

PAGES

1-8

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00467-018-4189-7

    DOI

    http://dx.doi.org/10.1007/s00467-018-4189-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112218900

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30778826


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