Ontology type: schema:ScholarlyArticle
2018-12-18
AUTHORSKoichi Kamei, Kenji Ishikura, Mayumi Sako, Shuichi Ito, Kandai Nozu, Kazumoto Iijima
ABSTRACTPatients with steroid-resistant nephrotic syndrome (SRNS) who develop resistance to immunosuppressive agents, defined as refractory SRNS, have poor renal outcomes. Although the chimeric anti-CD20 monoclonal antibody rituximab has shown efficacy for frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome, its efficacy for refractory SRNS remains uncertain due to limited data. According to previous case reports, 50.4% of patients with refractory SRNS showed clinical improvements after rituximab treatment. Remission rates in patients with initial steroid resistance and late steroid resistance were 43.9 and 57.7%, respectively, and 41.5 and 63.6% in patients with focal segmental glomerulosclerosis and minor glomerular abnormalities, respectively. However, various factors (race, disease severity, number of rituximab doses, concomitant treatments, and observation period) differed among these observational studies and their consensus may also have been affected by potential publication bias. Rituximab monotherapy may have some degree of efficacy and lead to satisfactory outcomes in a subset of patients with refractory SRNS. However, administration of concomitant treatments during rituximab-mediated B cell depletion, such as methylprednisolone pulse therapy, daily oral prednisolone therapy, and immunosuppressive agents, may lead to better outcomes in these patients. Large-scale, multi-center prospective studies are needed to evaluate the efficacy and safety of such regimens. More... »
PAGES17-24
http://scigraph.springernature.com/pub.10.1007/s00467-018-4166-1
DOIhttp://dx.doi.org/10.1007/s00467-018-4166-1
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1110754443
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30564879
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Resistance",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Therapy, Combination",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glucocorticoids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunosuppressive Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocyte Depletion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nephrotic Syndrome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Observational Studies as Topic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pulse Therapy, Drug",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recurrence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Remission Induction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rituximab",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.63906.3a",
"name": [
"Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kamei",
"givenName": "Koichi",
"id": "sg:person.01316365041.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316365041.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.63906.3a",
"name": [
"Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Ishikura",
"givenName": "Kenji",
"id": "sg:person.01112735663.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112735663.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division for Clinical Trials, Department of Clinical Research, Center for Clinical Research and Development, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.63906.3a",
"name": [
"Division for Clinical Trials, Department of Clinical Research, Center for Clinical Research and Development, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, 157-8535, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Sako",
"givenName": "Mayumi",
"id": "sg:person.01032464245.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032464245.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pediatrics, Graduate School of Medicine, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, 236-0004, Yokohama, Kanagawa, Japan",
"id": "http://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Pediatrics, Graduate School of Medicine, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, 236-0004, Yokohama, Kanagawa, Japan"
],
"type": "Organization"
},
"familyName": "Ito",
"givenName": "Shuichi",
"id": "sg:person.012302533312.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012302533312.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Hyogo, Japan",
"id": "http://www.grid.ac/institutes/grid.31432.37",
"name": [
"Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Hyogo, Japan"
],
"type": "Organization"
},
"familyName": "Nozu",
"givenName": "Kandai",
"id": "sg:person.0717317506.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717317506.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Hyogo, Japan",
"id": "http://www.grid.ac/institutes/grid.31432.37",
"name": [
"Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Hyogo, Japan"
],
"type": "Organization"
},
"familyName": "Iijima",
"givenName": "Kazumoto",
"id": "sg:person.01360637141.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360637141.54"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00467-009-1264-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014215541",
"https://doi.org/10.1007/s00467-009-1264-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-017-3746-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090744154",
"https://doi.org/10.1007/s00467-017-3746-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-018-3994-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1105406699",
"https://doi.org/10.1007/s00467-018-3994-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/pl00013420",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001860777",
"https://doi.org/10.1007/pl00013420"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-003-1314-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010752634",
"https://doi.org/10.1007/s00467-003-1314-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-013-2485-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039329871",
"https://doi.org/10.1007/s00467-013-2485-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-004-1584-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028397240",
"https://doi.org/10.1007/s00467-004-1584-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004670000494",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028129758",
"https://doi.org/10.1007/s004670000494"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-009-1376-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043363246",
"https://doi.org/10.1007/s00467-009-1376-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-012-2361-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017924951",
"https://doi.org/10.1007/s00467-012-2361-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-011-1778-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051524286",
"https://doi.org/10.1007/s00467-011-1778-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10157-016-1319-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022803771",
"https://doi.org/10.1007/s10157-016-1319-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-007-0640-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035964062",
"https://doi.org/10.1007/s00467-007-0640-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-014-2800-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013865385",
"https://doi.org/10.1007/s00467-014-2800-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-012-2319-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023506176",
"https://doi.org/10.1007/s00467-012-2319-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1918",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048825602",
"https://doi.org/10.1038/ng1918"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-009-1410-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040313036",
"https://doi.org/10.1007/s00467-009-1410-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-008-1030-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034882908",
"https://doi.org/10.1007/s00467-008-1030-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-015-3120-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024899507",
"https://doi.org/10.1007/s00467-015-3120-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-005-2013-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045340328",
"https://doi.org/10.1007/s00467-005-2013-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-009-1417-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020824519",
"https://doi.org/10.1007/s00467-009-1417-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11255-008-9393-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007937374",
"https://doi.org/10.1007/s11255-008-9393-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-012-2286-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009853115",
"https://doi.org/10.1007/s00467-012-2286-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-014-2765-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020955418",
"https://doi.org/10.1007/s00467-014-2765-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13312-017-0996-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003367239",
"https://doi.org/10.1007/s13312-017-0996-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-006-0096-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003470812",
"https://doi.org/10.1007/s00467-006-0096-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-009-1138-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048800371",
"https://doi.org/10.1007/s00467-009-1138-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-018-04193-w",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103956834",
"https://doi.org/10.1038/s41467-018-04193-w"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-017-3793-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092166342",
"https://doi.org/10.1007/s00467-017-3793-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-012-2314-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034124932",
"https://doi.org/10.1007/s00467-012-2314-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-009-1408-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019009454",
"https://doi.org/10.1007/s00467-009-1408-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-018-3900-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100938663",
"https://doi.org/10.1007/s00467-018-3900-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00467-009-1195-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028250994",
"https://doi.org/10.1007/s00467-009-1195-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10157-014-1030-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019458362",
"https://doi.org/10.1007/s10157-014-1030-x"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-12-18",
"datePublishedReg": "2018-12-18",
"description": "Patients with steroid-resistant nephrotic syndrome (SRNS) who develop resistance to immunosuppressive agents, defined as refractory SRNS, have poor renal outcomes. Although the chimeric anti-CD20 monoclonal antibody rituximab has shown efficacy for frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome, its efficacy for refractory SRNS remains uncertain due to limited data. According to previous case reports, 50.4% of patients with refractory SRNS showed clinical improvements after rituximab treatment. Remission rates in patients with initial steroid resistance and late steroid resistance were 43.9 and 57.7%, respectively, and 41.5 and 63.6% in patients with focal segmental glomerulosclerosis and minor glomerular abnormalities, respectively. However, various factors (race, disease severity, number of rituximab doses, concomitant treatments, and observation period) differed among these observational studies and their consensus may also have been affected by potential publication bias. Rituximab monotherapy may have some degree of efficacy and lead to satisfactory outcomes in a subset of patients with refractory SRNS. However, administration of concomitant treatments during rituximab-mediated B cell depletion, such as methylprednisolone pulse therapy, daily oral prednisolone therapy, and immunosuppressive agents, may lead to better outcomes in these patients. Large-scale, multi-center prospective studies are needed to evaluate the efficacy and safety of such regimens.",
"genre": "article",
"id": "sg:pub.10.1007/s00467-018-4166-1",
"inLanguage": "en",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.9337961",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7853213",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1097267",
"issn": [
"0931-041X",
"1432-198X"
],
"name": "Pediatric Nephrology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "35"
}
],
"keywords": [
"refractory steroid-resistant nephrotic syndrome",
"steroid-resistant nephrotic syndrome",
"nephrotic syndrome",
"steroid resistance",
"immunosuppressive agents",
"steroid-dependent nephrotic syndrome",
"multi-center prospective study",
"initial steroid resistance",
"late steroid resistance",
"methylprednisolone pulse therapy",
"oral prednisolone therapy",
"poor renal outcome",
"subset of patients",
"CD20 monoclonal antibody",
"minor glomerular abnormalities",
"previous case reports",
"focal segmental glomerulosclerosis",
"potential publication bias",
"degree of efficacy",
"pulse therapy",
"prednisolone therapy",
"renal outcomes",
"rituximab treatment",
"rituximab monotherapy",
"rituximab therapy",
"clinical improvement",
"remission rate",
"glomerular abnormalities",
"cell depletion",
"prospective study",
"such regimens",
"concomitant treatment",
"case report",
"segmental glomerulosclerosis",
"observational study",
"better outcomes",
"patients",
"satisfactory outcome",
"publication bias",
"syndrome",
"monoclonal antibodies",
"therapy",
"efficacy",
"limited data",
"outcomes",
"treatment",
"monotherapy",
"regimens",
"glomerulosclerosis",
"agents",
"abnormalities",
"administration",
"antibodies",
"children",
"study",
"resistance",
"report",
"safety",
"subset",
"depletion",
"factors",
"consensus",
"rate",
"improvement",
"data",
"lead",
"bias",
"degree"
],
"name": "Rituximab therapy for refractory steroid-resistant nephrotic syndrome in children",
"pagination": "17-24",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1110754443"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00467-018-4166-1"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30564879"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00467-018-4166-1",
"https://app.dimensions.ai/details/publication/pub.1110754443"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:17",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_764.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00467-018-4166-1"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00467-018-4166-1'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00467-018-4166-1'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00467-018-4166-1'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00467-018-4166-1'
This table displays all metadata directly associated to this object as RDF triples.
373 TRIPLES
22 PREDICATES
143 URIs
101 LITERALS
22 BLANK NODES