Pharmacogenetics of post-transplant diabetes mellitus in children with renal transplantation treated with tacrolimus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Pauline Lancia, Tiphaine Adam de Beaumais, Valéry Elie, Florentine Garaix, Marc Fila, François Nobili, Bruno Ranchin, Pascale Testevuide, Tim Ulinski, Wei Zhao, Georges Deschênes, Evelyne Jacqz-Aigrain

ABSTRACT

BACKGROUND: Post-transplant diabetes mellitus (PTDM) is a major complication of immunosuppressive therapy, with many risk factors reported in adults with renal transplantation. The objective of this study was to investigate potential non-genetic and genetic risk factors of PTDM in children with renal transplantation treated with tacrolimus. METHODS: A national database was screened for patients developing PTDM within 4 years following tacrolimus introduction. PTDM was defined as glucose disorder requiring anti-diabetic treatment. PTDM patients were matched to "non-PTDM" control transplanted children according to age, gender, and duration of post-transplant follow-up. Patients were genotyped for six selected genetic variants in POR*28 (rs1057868), PPARa (rs4253728), CYP3A5 (rs776746), VDR (rs2228570 and rs731236), and ABCB1 (rs1045642) genes, implicated in glucose homeostasis and tacrolimus disposition. RESULTS: Among the 98 children with renal transplantation enrolled in this multicentre study, 18 developed PTDM. None of the clinical and biological parameters was significant between PTDM and control patients. Homozygous carriers of POR*28 or wild-type ABCB1 (rs1045642) gene variants were more frequent in PTDM than in control patients with differences close to significance (p = 0.114 and p = 0.066 respectively). A genetic score based on these variants demonstrated that POR*28/*28 and ABCB1 CC or CT genotype carriers were at a significantly higher risk of developing PTDM after renal transplantation. CONCLUSION: Identification of PTDM risk factors should allow clinicians to allocate the best immunosuppressant for each patient with renal transplantation, and improve care for patients who are at a higher risk. More... »

PAGES

1045-1055

References to SciGraph publications

  • 2015-03. New-onset diabetes after kidney transplant in children in PEDIATRIC NEPHROLOGY
  • 2001-02. Post-transplant diabetes mellitus: Increasing incidence in renal allograft recipients transplanted in recent years in KIDNEY INTERNATIONAL
  • 2002-01. Increased incidence in post-transplant diabetes mellitus in children: a case-control analysis in PEDIATRIC NEPHROLOGY
  • 2010-04. Effects of steroid avoidance and novel protocols on growth in paediatric renal transplant patients in PEDIATRIC NEPHROLOGY
  • 2007-07. Bardet–Biedl syndrome: beyond the cilium in PEDIATRIC NEPHROLOGY
  • 2012-06. PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2007-02. Childhood hemolytic uremic syndrome is associated with adolescent-onset diabetes mellitus in PEDIATRIC NEPHROLOGY
  • 2002-10. Patient survival after renal transplantation: IV. Impact of post-transplant diabetes in KIDNEY INTERNATIONAL
  • 2010-07. Risk factors for new-onset diabetes after kidney transplantation in NATURE REVIEWS NEPHROLOGY
  • 2017-06. Pharmacogenetics of posttransplant diabetes mellitus in THE PHARMACOGENOMICS JOURNAL
  • 2004-01. Polymorphisms in Human MDR1 (P‐glycoprotein): Recent Advances and Clinical Relevance in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2017-05. Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients in PEDIATRIC NEPHROLOGY
  • 2005-06. New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation in KIDNEY INTERNATIONAL
  • 2014-06. The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00467-017-3881-3

    DOI

    http://dx.doi.org/10.1007/s00467-017-3881-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100823573

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29399716


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