Focal segmental glomerulosclerosis and medullary nephrocalcinosis in children with ADCK4 mutations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-12

AUTHORS

Eujin Park, Hee Gyung Kang, Young Hun Choi, Kyoung Bun Lee, Kyung Chul Moon, Hyeon Joo Jeong, Michio Nagata, Hae Il Cheong

ABSTRACT

BackgroundMutations in the AarF domain containing kinase 4 gene (ADCK4), one of the novel genes causing steroid-resistant nephrotic syndrome (SRNS), usually manifest as isolated adolescent-onset focal segmental glomerulosclerosis (FSGS). ADCK4 interacts with components of the coenzyme Q10 (CoQ10) biosynthesis pathway.MethodsThe incidence and phenotypes of patients with ADCK4 mutations were investigated in a cohort of Korean pediatric patients with SRNS.ResultsAmong the 53 patients enrolled in the study the incidence of ADCK4-associated FSGS was 7.5% (n = 4) in children aged 5 years and older with multidrug-resistant FSGS. Two additional patients were included for phenotype analyses, one detected by family screening and the other with cyclosporine-responsive FSGS. These six patients presented proteinuria without overt nephrotic syndrome at a median age of 110 (range 60–153) months, of whom five progressed to end-stage renal disease within a median period of 46 (range 36–79) months after onset. Renal biopsies revealed mitochondrial abnormalities in podocytes and tubular cells of all patients. Notably, all patients showed accompanying medullary nephrocalcinosis. None of the patients showed other extrarenal manifestations.ConclusionsADCK4 mutations should be considered in older children presenting with steroid resistant FSGS. An early diagnosis of ADCK4 mutations is essential because the condition is treatable with CoQ10 supplementation at an early stage. The association with medullary nephrocalcinosis may be an additional diagnostic indicator. More... »

PAGES

1547-1554

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-017-3657-9

DOI

http://dx.doi.org/10.1007/s00467-017-3657-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084815209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28405841


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Association Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulosclerosis, Focal Segmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Failure, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Korea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephrocalcinosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephrotic Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Seoul National University Children\u2019s Hospital, 101 Daehak-Ro, Jongno-Gu, 03080, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412482.9", 
          "name": [
            "Department of Pediatrics, Seoul National University Children\u2019s Hospital, 101 Daehak-Ro, Jongno-Gu, 03080, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Eujin", 
        "id": "sg:person.01264734630.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264734630.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Coordination Center for Rare Diseases, Seoul National University Hospital, 03080, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Pediatrics, Seoul National University Children\u2019s Hospital, 101 Daehak-Ro, Jongno-Gu, 03080, Seoul, South Korea", 
            "Research Coordination Center for Rare Diseases, Seoul National University Hospital, 03080, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Hee Gyung", 
        "id": "sg:person.01326241545.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326241545.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Seoul National University College of Medicine, 03080, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Radiology, Seoul National University College of Medicine, 03080, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Young Hun", 
        "id": "sg:person.015517607114.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015517607114.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Seoul National University Hospital, 03080, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Pathology, Seoul National University Hospital, 03080, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyoung Bun", 
        "id": "sg:person.01204275617.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204275617.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, 03080, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Pathology, Seoul National University Hospital, 03080, Seoul, South Korea", 
            "Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, 03080, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moon", 
        "givenName": "Kyung Chul", 
        "id": "sg:person.01103153136.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103153136.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "Hyeon Joo", 
        "id": "sg:person.010675647015.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010675647015.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagata", 
        "givenName": "Michio", 
        "id": "sg:person.01022702772.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022702772.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, 03080, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Pediatrics, Seoul National University Children\u2019s Hospital, 101 Daehak-Ro, Jongno-Gu, 03080, Seoul, South Korea", 
            "Research Coordination Center for Rare Diseases, Seoul National University Hospital, 03080, Seoul, South Korea", 
            "Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, 03080, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheong", 
        "givenName": "Hae Il", 
        "id": "sg:person.01135777524.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135777524.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00240-008-0165-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010825864", 
          "https://doi.org/10.1007/s00240-008-0165-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00240-006-0061-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041479157", 
          "https://doi.org/10.1007/s00240-006-0061-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-011-1926-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029112129", 
          "https://doi.org/10.1007/s00467-011-1926-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-04-12", 
    "datePublishedReg": "2017-04-12", 
    "description": "BackgroundMutations in the AarF domain containing kinase 4 gene (ADCK4), one of the novel genes causing steroid-resistant nephrotic syndrome (SRNS), usually manifest as isolated adolescent-onset focal segmental glomerulosclerosis (FSGS). ADCK4 interacts with components of the coenzyme Q10 (CoQ10) biosynthesis pathway.MethodsThe incidence and phenotypes of patients with ADCK4 mutations were investigated in a cohort of Korean pediatric patients with SRNS.ResultsAmong the 53 patients enrolled in the study the incidence of ADCK4-associated FSGS was 7.5% (n = 4) in children aged 5 years and older with multidrug-resistant FSGS. Two additional patients were included for phenotype analyses, one detected by family screening and the other with cyclosporine-responsive FSGS. These six patients presented proteinuria without overt nephrotic syndrome at a median age of 110 (range 60\u2013153) months, of whom five progressed to end-stage renal disease within a median period of 46 (range 36\u201379)\u00a0months after onset. Renal biopsies revealed mitochondrial abnormalities in podocytes and tubular cells of all patients. Notably, all patients showed accompanying medullary nephrocalcinosis. None of the patients showed other extrarenal manifestations.ConclusionsADCK4 mutations should be considered in older children presenting with steroid resistant FSGS. An early diagnosis of ADCK4 mutations is essential because the condition is treatable with CoQ10 supplementation at an early stage. The association with medullary nephrocalcinosis may be an additional diagnostic indicator.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00467-017-3657-9", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097267", 
        "issn": [
          "0931-041X", 
          "1432-198X"
        ], 
        "name": "Pediatric Nephrology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "keywords": [
      "steroid-resistant nephrotic syndrome", 
      "focal segmental glomerulosclerosis", 
      "ADCK4 mutations", 
      "medullary nephrocalcinosis", 
      "nephrotic syndrome", 
      "segmental glomerulosclerosis", 
      "resistant focal segmental glomerulosclerosis", 
      "steroid-resistant focal segmental glomerulosclerosis", 
      "end-stage renal disease", 
      "Korean pediatric patients", 
      "overt nephrotic syndrome", 
      "phenotype of patients", 
      "kinase 4 gene", 
      "MethodsThe incidence", 
      "pediatric patients", 
      "median age", 
      "renal disease", 
      "renal biopsy", 
      "additional patients", 
      "median period", 
      "CoQ10 supplementation", 
      "additional diagnostic indicator", 
      "extrarenal manifestations", 
      "family screening", 
      "early diagnosis", 
      "tubular cells", 
      "patients", 
      "coenzyme Q10 biosynthesis pathway", 
      "nephrocalcinosis", 
      "mitochondrial abnormalities", 
      "older children", 
      "glomerulosclerosis", 
      "diagnostic indicators", 
      "AarF domain", 
      "syndrome", 
      "ADCK4", 
      "incidence", 
      "children", 
      "months", 
      "phenotype analysis", 
      "mutations", 
      "early stages", 
      "proteinuria", 
      "ResultsAmong", 
      "biopsy", 
      "cohort", 
      "BackgroundMutations", 
      "abnormalities", 
      "disease", 
      "diagnosis", 
      "supplementation", 
      "podocytes", 
      "manifestations", 
      "age", 
      "onset", 
      "genes", 
      "association", 
      "screening", 
      "phenotype", 
      "novel genes", 
      "cells", 
      "years", 
      "pathway", 
      "period", 
      "study", 
      "stage", 
      "indicators", 
      "biosynthesis pathway", 
      "analysis", 
      "components", 
      "conditions", 
      "domain"
    ], 
    "name": "Focal segmental glomerulosclerosis and medullary nephrocalcinosis in children with ADCK4 mutations", 
    "pagination": "1547-1554", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084815209"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00467-017-3657-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28405841"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00467-017-3657-9", 
      "https://app.dimensions.ai/details/publication/pub.1084815209"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_744.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00467-017-3657-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00467-017-3657-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00467-017-3657-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00467-017-3657-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00467-017-3657-9'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      21 PREDICATES      114 URIs      103 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00467-017-3657-9 schema:about N02f424b0c07f4360801e64e5c25fb510
2 N19f8016b7bf847f9aa829569907c3028
3 N32b9bb6d0ce94b669160389fff1ec311
4 N33c85de0f50e41639b5dae5d5c1a9ebe
5 N469359c437044e5a8c7228ef8ed25060
6 N572335282eea4f77946edfd128a7041c
7 N5cd4203eaa834b5db4e0ae0cc730221d
8 N68743760c16640bda88239276605130f
9 N7255d0bc924945b2beb28be8ad15b7cc
10 N8b65217c132d432783a1cd6e84ba9c5c
11 N8d7d45ff1dd047f59508b44f6fc9d549
12 Nc850d00effa04b2598a1d7e910235b64
13 Ne65b92bea97b4a29a4734e92aca7480f
14 Nee30728330704124b57e5d7a2c4a27fc
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Na3b9e868b55c4d71b69c898e553fc694
18 schema:citation sg:pub.10.1007/s00240-006-0061-5
19 sg:pub.10.1007/s00240-008-0165-1
20 sg:pub.10.1007/s00467-011-1926-6
21 schema:datePublished 2017-04-12
22 schema:datePublishedReg 2017-04-12
23 schema:description BackgroundMutations in the AarF domain containing kinase 4 gene (ADCK4), one of the novel genes causing steroid-resistant nephrotic syndrome (SRNS), usually manifest as isolated adolescent-onset focal segmental glomerulosclerosis (FSGS). ADCK4 interacts with components of the coenzyme Q10 (CoQ10) biosynthesis pathway.MethodsThe incidence and phenotypes of patients with ADCK4 mutations were investigated in a cohort of Korean pediatric patients with SRNS.ResultsAmong the 53 patients enrolled in the study the incidence of ADCK4-associated FSGS was 7.5% (n = 4) in children aged 5 years and older with multidrug-resistant FSGS. Two additional patients were included for phenotype analyses, one detected by family screening and the other with cyclosporine-responsive FSGS. These six patients presented proteinuria without overt nephrotic syndrome at a median age of 110 (range 60–153) months, of whom five progressed to end-stage renal disease within a median period of 46 (range 36–79) months after onset. Renal biopsies revealed mitochondrial abnormalities in podocytes and tubular cells of all patients. Notably, all patients showed accompanying medullary nephrocalcinosis. None of the patients showed other extrarenal manifestations.ConclusionsADCK4 mutations should be considered in older children presenting with steroid resistant FSGS. An early diagnosis of ADCK4 mutations is essential because the condition is treatable with CoQ10 supplementation at an early stage. The association with medullary nephrocalcinosis may be an additional diagnostic indicator.
24 schema:genre article
25 schema:isAccessibleForFree false
26 schema:isPartOf N1add602bc73f4f05b6a969c49b80c77f
27 N2598d28ab1c944c8be8df22d589492a9
28 sg:journal.1097267
29 schema:keywords ADCK4
30 ADCK4 mutations
31 AarF domain
32 BackgroundMutations
33 CoQ10 supplementation
34 Korean pediatric patients
35 MethodsThe incidence
36 ResultsAmong
37 abnormalities
38 additional diagnostic indicator
39 additional patients
40 age
41 analysis
42 association
43 biopsy
44 biosynthesis pathway
45 cells
46 children
47 coenzyme Q10 biosynthesis pathway
48 cohort
49 components
50 conditions
51 diagnosis
52 diagnostic indicators
53 disease
54 domain
55 early diagnosis
56 early stages
57 end-stage renal disease
58 extrarenal manifestations
59 family screening
60 focal segmental glomerulosclerosis
61 genes
62 glomerulosclerosis
63 incidence
64 indicators
65 kinase 4 gene
66 manifestations
67 median age
68 median period
69 medullary nephrocalcinosis
70 mitochondrial abnormalities
71 months
72 mutations
73 nephrocalcinosis
74 nephrotic syndrome
75 novel genes
76 older children
77 onset
78 overt nephrotic syndrome
79 pathway
80 patients
81 pediatric patients
82 period
83 phenotype
84 phenotype analysis
85 phenotype of patients
86 podocytes
87 proteinuria
88 renal biopsy
89 renal disease
90 resistant focal segmental glomerulosclerosis
91 screening
92 segmental glomerulosclerosis
93 stage
94 steroid-resistant focal segmental glomerulosclerosis
95 steroid-resistant nephrotic syndrome
96 study
97 supplementation
98 syndrome
99 tubular cells
100 years
101 schema:name Focal segmental glomerulosclerosis and medullary nephrocalcinosis in children with ADCK4 mutations
102 schema:pagination 1547-1554
103 schema:productId N9ed5d401b1a34a8ab7958d15bb976fa9
104 Nb3078b5479754556bc8e8333445d9d00
105 Nb72a3f1ea90f49a6abe36d95c2f25e2e
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084815209
107 https://doi.org/10.1007/s00467-017-3657-9
108 schema:sdDatePublished 2022-12-01T06:36
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N8c545aaabc40425a9089561cfdd1ee41
111 schema:url https://doi.org/10.1007/s00467-017-3657-9
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N02f424b0c07f4360801e64e5c25fb510 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Protein Kinases
117 rdf:type schema:DefinedTerm
118 N19f8016b7bf847f9aa829569907c3028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Nephrocalcinosis
120 rdf:type schema:DefinedTerm
121 N1add602bc73f4f05b6a969c49b80c77f schema:issueNumber 9
122 rdf:type schema:PublicationIssue
123 N2598d28ab1c944c8be8df22d589492a9 schema:volumeNumber 32
124 rdf:type schema:PublicationVolume
125 N32b9bb6d0ce94b669160389fff1ec311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Nephrotic Syndrome
127 rdf:type schema:DefinedTerm
128 N33c85de0f50e41639b5dae5d5c1a9ebe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Kidney Failure, Chronic
130 rdf:type schema:DefinedTerm
131 N469359c437044e5a8c7228ef8ed25060 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Male
133 rdf:type schema:DefinedTerm
134 N572335282eea4f77946edfd128a7041c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Disease Progression
136 rdf:type schema:DefinedTerm
137 N5cd4203eaa834b5db4e0ae0cc730221d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Humans
139 rdf:type schema:DefinedTerm
140 N68743760c16640bda88239276605130f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Incidence
142 rdf:type schema:DefinedTerm
143 N711fe89ce38c4f81aaf95a41cad35065 rdf:first sg:person.01135777524.13
144 rdf:rest rdf:nil
145 N7255d0bc924945b2beb28be8ad15b7cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Mutation
147 rdf:type schema:DefinedTerm
148 N8b65217c132d432783a1cd6e84ba9c5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Glomerulosclerosis, Focal Segmental
150 rdf:type schema:DefinedTerm
151 N8c20bd8b585d42358df192c6dfc64b3f rdf:first sg:person.010675647015.12
152 rdf:rest N95e587822c49441ba083ec5683e7dd1d
153 N8c545aaabc40425a9089561cfdd1ee41 schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 N8d7d45ff1dd047f59508b44f6fc9d549 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Korea
157 rdf:type schema:DefinedTerm
158 N95e587822c49441ba083ec5683e7dd1d rdf:first sg:person.01022702772.51
159 rdf:rest N711fe89ce38c4f81aaf95a41cad35065
160 N967196cdcaf440338a65c51b64f401fd rdf:first sg:person.015517607114.36
161 rdf:rest N985cfa989e1042a7b90f71392191b606
162 N985cfa989e1042a7b90f71392191b606 rdf:first sg:person.01204275617.31
163 rdf:rest Nc917e19c36ba4c71a454cc78a358a7bf
164 N9ed5d401b1a34a8ab7958d15bb976fa9 schema:name doi
165 schema:value 10.1007/s00467-017-3657-9
166 rdf:type schema:PropertyValue
167 Na3b9e868b55c4d71b69c898e553fc694 rdf:first sg:person.01264734630.65
168 rdf:rest Nafc4a342abd64ab99b1395541bc34acf
169 Nafc4a342abd64ab99b1395541bc34acf rdf:first sg:person.01326241545.16
170 rdf:rest N967196cdcaf440338a65c51b64f401fd
171 Nb3078b5479754556bc8e8333445d9d00 schema:name dimensions_id
172 schema:value pub.1084815209
173 rdf:type schema:PropertyValue
174 Nb72a3f1ea90f49a6abe36d95c2f25e2e schema:name pubmed_id
175 schema:value 28405841
176 rdf:type schema:PropertyValue
177 Nc850d00effa04b2598a1d7e910235b64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Female
179 rdf:type schema:DefinedTerm
180 Nc917e19c36ba4c71a454cc78a358a7bf rdf:first sg:person.01103153136.10
181 rdf:rest N8c20bd8b585d42358df192c6dfc64b3f
182 Ne65b92bea97b4a29a4734e92aca7480f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Child
184 rdf:type schema:DefinedTerm
185 Nee30728330704124b57e5d7a2c4a27fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Genetic Association Studies
187 rdf:type schema:DefinedTerm
188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
189 schema:name Medical and Health Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
192 schema:name Clinical Sciences
193 rdf:type schema:DefinedTerm
194 sg:journal.1097267 schema:issn 0931-041X
195 1432-198X
196 schema:name Pediatric Nephrology
197 schema:publisher Springer Nature
198 rdf:type schema:Periodical
199 sg:person.01022702772.51 schema:affiliation grid-institutes:grid.20515.33
200 schema:familyName Nagata
201 schema:givenName Michio
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022702772.51
203 rdf:type schema:Person
204 sg:person.010675647015.12 schema:affiliation grid-institutes:grid.15444.30
205 schema:familyName Jeong
206 schema:givenName Hyeon Joo
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010675647015.12
208 rdf:type schema:Person
209 sg:person.01103153136.10 schema:affiliation grid-institutes:grid.31501.36
210 schema:familyName Moon
211 schema:givenName Kyung Chul
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103153136.10
213 rdf:type schema:Person
214 sg:person.01135777524.13 schema:affiliation grid-institutes:grid.31501.36
215 schema:familyName Cheong
216 schema:givenName Hae Il
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135777524.13
218 rdf:type schema:Person
219 sg:person.01204275617.31 schema:affiliation grid-institutes:grid.412484.f
220 schema:familyName Lee
221 schema:givenName Kyoung Bun
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204275617.31
223 rdf:type schema:Person
224 sg:person.01264734630.65 schema:affiliation grid-institutes:grid.412482.9
225 schema:familyName Park
226 schema:givenName Eujin
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264734630.65
228 rdf:type schema:Person
229 sg:person.01326241545.16 schema:affiliation grid-institutes:grid.412484.f
230 schema:familyName Kang
231 schema:givenName Hee Gyung
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326241545.16
233 rdf:type schema:Person
234 sg:person.015517607114.36 schema:affiliation grid-institutes:grid.31501.36
235 schema:familyName Choi
236 schema:givenName Young Hun
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015517607114.36
238 rdf:type schema:Person
239 sg:pub.10.1007/s00240-006-0061-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041479157
240 https://doi.org/10.1007/s00240-006-0061-5
241 rdf:type schema:CreativeWork
242 sg:pub.10.1007/s00240-008-0165-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010825864
243 https://doi.org/10.1007/s00240-008-0165-1
244 rdf:type schema:CreativeWork
245 sg:pub.10.1007/s00467-011-1926-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029112129
246 https://doi.org/10.1007/s00467-011-1926-6
247 rdf:type schema:CreativeWork
248 grid-institutes:grid.15444.30 schema:alternateName Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea
249 schema:name Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea
250 rdf:type schema:Organization
251 grid-institutes:grid.20515.33 schema:alternateName Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
252 schema:name Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
253 rdf:type schema:Organization
254 grid-institutes:grid.31501.36 schema:alternateName Department of Radiology, Seoul National University College of Medicine, 03080, Seoul, South Korea
255 Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, 03080, Seoul, South Korea
256 schema:name Department of Pathology, Seoul National University Hospital, 03080, Seoul, South Korea
257 Department of Pediatrics, Seoul National University Children’s Hospital, 101 Daehak-Ro, Jongno-Gu, 03080, Seoul, South Korea
258 Department of Radiology, Seoul National University College of Medicine, 03080, Seoul, South Korea
259 Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, 03080, Seoul, South Korea
260 Research Coordination Center for Rare Diseases, Seoul National University Hospital, 03080, Seoul, South Korea
261 rdf:type schema:Organization
262 grid-institutes:grid.412482.9 schema:alternateName Department of Pediatrics, Seoul National University Children’s Hospital, 101 Daehak-Ro, Jongno-Gu, 03080, Seoul, South Korea
263 schema:name Department of Pediatrics, Seoul National University Children’s Hospital, 101 Daehak-Ro, Jongno-Gu, 03080, Seoul, South Korea
264 rdf:type schema:Organization
265 grid-institutes:grid.412484.f schema:alternateName Department of Pathology, Seoul National University Hospital, 03080, Seoul, South Korea
266 Research Coordination Center for Rare Diseases, Seoul National University Hospital, 03080, Seoul, South Korea
267 schema:name Department of Pathology, Seoul National University Hospital, 03080, Seoul, South Korea
268 Department of Pediatrics, Seoul National University Children’s Hospital, 101 Daehak-Ro, Jongno-Gu, 03080, Seoul, South Korea
269 Research Coordination Center for Rare Diseases, Seoul National University Hospital, 03080, Seoul, South Korea
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...