Nephrotoxicity in children with frequently relapsing nephrotic syndrome receiving long-term cyclosporine treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-04

AUTHORS

Yuko Hamasaki, Fumiyo Komaki, Kenji Ishikura, Riku Hamada, Tomoyuki Sakai, Hiroshi Hataya, Kentaro Ogata, Takashi Ando, Masataka Honda

ABSTRACT

BackgroundSteroid-sparing drugs, such as cyclosporine, are recommended as treatment for children with frequently relapsing nephrotic syndrome (FRNS) and steroid-related toxicities. We recently reported a high rate of relapsing nephrotic syndrome 2 years after discontinuation of cyclosporine treatment, suggesting that long-term treatment is necessary. Cyclosporine-associated nephrotoxicity (CAN) is a potential side effect of long-term cyclosporine treatment.MethodsWe retrospectively reviewed pediatric patients with FRNS treated with cyclosporine for ≥3 years at a single center between 1999 and 2012. The cyclosporine dose was adjusted to maintain the whole-blood cyclosporine trough level at 80–100 ng/ml for 6 months, at 60–80 ng/ml for 18 months, and then at around 50–60 ng/ml thereafter. Maintenance dose of prednisolone was not prescribed. CAN was graded in terms of arteriolar hyalinosis and the degree of interstitial fibrosis.ResultsThirty-six children (28 males) were enrolled in the study. The median age at the start of long-term cyclosporine treatment was 9.4 years. The median duration of the longest period of cyclosporine treatment was 4.5 years. Most CAN cases were characterized by arteriolar hyalinosis. The frequency of CAN was positively correlated with the duration of cyclosporine treatment, with an odds ratio (95% confidence interval) for CAN of 3.84 (0.79–18.74) after 2–5 years and 6.60 (1.18–36.94) after >5 years of cyclosporine treatment (vs. 0–2 years).ConclusionsAlthough the frequency of CAN was correlated with the duration of cyclosporine treatment in our pediatric patient population, most cases of CAN involved arteriolar hyalinosis. We conclude that long-term cyclosporine treatment is useful for treating FRNS in children, providing its dose is controlled and kidney biopsies are regularly performed. More... »

PAGES

1383-1390

References to SciGraph publications

  • 2015-01-10. Positive role of rituximab in switching from cyclosporine to mycophenolate mofetil for children with high-dose steroid-dependent nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2013-09-07. Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease in CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • 2015-02-06. Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: medical therapy in CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • 2005-06-24. Mycophenolate mofetil therapy in frequently relapsing steroid-dependent and steroid-resistant nephrotic syndrome of childhood: current status and future directions in PEDIATRIC NEPHROLOGY
  • 2000-02. Long-term clinical and pathological effects of cyclosporin in children with nephrosis in PEDIATRIC NEPHROLOGY
  • 2004-05-25. Single-dose daily administration of cyclosporin A for relapsing nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 1999-02. Two-year cyclosporin treatment in children with steroid-dependent nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2003-05-28. Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2008-11-01. Mycophenolate mofetil versus cyclosporine for remission maintenance in nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2001-09. Recovery from cyclosporine-associated arteriolopathy in childhood nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2013-07-09. Uncertainty in management of childhood-onset idiopathic nephrotic syndrome: is the long-term prognosis really favorable? in PEDIATRIC NEPHROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00467-017-3641-4

    DOI

    http://dx.doi.org/10.1007/s00467-017-3641-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084513328

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28378029


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biopsy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child, Preschool", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclosporine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibrosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glucocorticoids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Long-Term Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Maintenance Chemotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nephrotic Syndrome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prednisolone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417084.e", 
              "name": [
                "Department of Pediatric Nephrology, Faculty of Medicine, Toho University, 6-11-1 Omori-Nishi, Ota-Ku, 143-8541, Tokyo, Japan", 
                "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hamasaki", 
            "givenName": "Yuko", 
            "id": "sg:person.01161051063.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161051063.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Infectious Diseases Control, Health and Welfare Bureau Health Center of Kawasaki City, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Division of Infectious Diseases Control, Health and Welfare Bureau Health Center of Kawasaki City, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Komaki", 
            "givenName": "Fumiyo", 
            "id": "sg:person.01047135477.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047135477.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.63906.3a", 
              "name": [
                "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan", 
                "Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishikura", 
            "givenName": "Kenji", 
            "id": "sg:person.01112735663.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112735663.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417084.e", 
              "name": [
                "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hamada", 
            "givenName": "Riku", 
            "id": "sg:person.0601607245.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601607245.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakai", 
            "givenName": "Tomoyuki", 
            "id": "sg:person.01127413231.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127413231.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417084.e", 
              "name": [
                "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hataya", 
            "givenName": "Hiroshi", 
            "id": "sg:person.01175526431.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175526431.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417084.e", 
              "name": [
                "Department of Pathology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogata", 
            "givenName": "Kentaro", 
            "id": "sg:person.01033670077.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033670077.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Data Management, Japan Clinical Research Support Unit, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Data Management, Japan Clinical Research Support Unit, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ando", 
            "givenName": "Takashi", 
            "id": "sg:person.01237524620.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237524620.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417084.e", 
              "name": [
                "Department of Nephrology, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Honda", 
            "givenName": "Masataka", 
            "id": "sg:person.01300112777.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300112777.86"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10157-014-1030-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019458362", 
              "https://doi.org/10.1007/s10157-014-1030-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-008-0899-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019693863", 
              "https://doi.org/10.1007/s00467-008-0899-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004670050044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003486257", 
              "https://doi.org/10.1007/s004670050044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-005-1964-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044731039", 
              "https://doi.org/10.1007/s00467-005-1964-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004670050558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045165754", 
              "https://doi.org/10.1007/s004670050558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-013-2553-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009379940", 
              "https://doi.org/10.1007/s00467-013-2553-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-004-1508-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033184947", 
              "https://doi.org/10.1007/s00467-004-1508-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004670100646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053137495", 
              "https://doi.org/10.1007/s004670100646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-014-3034-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039114622", 
              "https://doi.org/10.1007/s00467-014-3034-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10157-013-0856-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040454736", 
              "https://doi.org/10.1007/s10157-013-0856-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-003-1175-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010530284", 
              "https://doi.org/10.1007/s00467-003-1175-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-04-04", 
        "datePublishedReg": "2017-04-04", 
        "description": "BackgroundSteroid-sparing drugs, such as cyclosporine, are recommended as treatment for children with frequently relapsing nephrotic syndrome (FRNS) and steroid-related toxicities. We recently reported a high rate of relapsing nephrotic syndrome 2\u00a0years after discontinuation of cyclosporine treatment, suggesting that long-term treatment is necessary. Cyclosporine-associated nephrotoxicity (CAN) is a potential side effect of long-term cyclosporine treatment.MethodsWe retrospectively reviewed pediatric patients with FRNS treated with cyclosporine for \u22653\u00a0years at a single center between 1999 and 2012. The cyclosporine dose was adjusted to maintain the whole-blood cyclosporine trough level at 80\u2013100\u00a0ng/ml for 6\u00a0months, at 60\u201380\u00a0ng/ml for 18\u00a0months, and then at around 50\u201360\u00a0ng/ml thereafter. Maintenance dose of prednisolone was not prescribed. CAN was graded in terms of arteriolar hyalinosis and the degree of interstitial fibrosis.ResultsThirty-six children (28 males) were enrolled in the study. The median age at the start of long-term cyclosporine treatment was 9.4\u00a0years. The median duration of the longest period of cyclosporine treatment was 4.5\u00a0years. Most CAN cases were characterized by arteriolar hyalinosis. The frequency of CAN was positively correlated with the duration of cyclosporine treatment, with an odds ratio (95% confidence interval) for CAN of 3.84 (0.79\u201318.74) after 2\u20135 years and 6.60 (1.18\u201336.94) after >5\u00a0years of cyclosporine treatment (vs. 0\u20132 years).ConclusionsAlthough the frequency of CAN was correlated with the duration of cyclosporine treatment in our pediatric patient population, most cases of CAN involved arteriolar hyalinosis. We conclude that long-term cyclosporine treatment is useful for treating FRNS in children, providing its dose is controlled and kidney biopsies are regularly performed.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00467-017-3641-4", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.9341874", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097267", 
            "issn": [
              "0931-041X", 
              "1432-198X"
            ], 
            "name": "Pediatric Nephrology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "32"
          }
        ], 
        "keywords": [
          "long-term cyclosporine treatment", 
          "cyclosporine-associated nephrotoxicity", 
          "cyclosporine treatment", 
          "arteriolar hyalinosis", 
          "nephrotic syndrome", 
          "steroid-related toxicities", 
          "cyclosporine trough levels", 
          "pediatric patient population", 
          "long-term treatment", 
          "potential side effects", 
          "cyclosporine dose", 
          "maintenance dose", 
          "median duration", 
          "pediatric patients", 
          "trough levels", 
          "median age", 
          "single center", 
          "kidney biopsy", 
          "interstitial fibrosis", 
          "patient population", 
          "odds ratio", 
          "side effects", 
          "syndrome 2", 
          "hyalinosis", 
          "dose", 
          "cyclosporine", 
          "treatment", 
          "nephrotoxicity", 
          "syndrome", 
          "children", 
          "high rate", 
          "FRNS", 
          "months", 
          "duration", 
          "CAN cases", 
          "years", 
          "most cases", 
          "BackgroundSteroids", 
          "discontinuation", 
          "prednisolone", 
          "patients", 
          "biopsy", 
          "fibrosis", 
          "MethodsWe", 
          "ConclusionsAlthough", 
          "drugs", 
          "age", 
          "cases", 
          "long period", 
          "toxicity", 
          "population", 
          "frequency", 
          "period", 
          "levels", 
          "center", 
          "start", 
          "study", 
          "rate", 
          "effect", 
          "ratio", 
          "degree", 
          "terms"
        ], 
        "name": "Nephrotoxicity in children with frequently relapsing nephrotic syndrome receiving long-term cyclosporine treatment", 
        "pagination": "1383-1390", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084513328"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00467-017-3641-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28378029"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00467-017-3641-4", 
          "https://app.dimensions.ai/details/publication/pub.1084513328"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_744.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00467-017-3641-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00467-017-3641-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00467-017-3641-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00467-017-3641-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00467-017-3641-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    304 TRIPLES      21 PREDICATES      114 URIs      95 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00467-017-3641-4 schema:about N15f0a3fc80694a34855987efee7bf16c
    2 N1c2bc3e23ae54c7dbe653dbe3d91fb62
    3 N476f87dc8f864920bc53780b25640133
    4 N54a7ac31feb74d9eb10478ae26791447
    5 N5905317f6a2f4d069265bf481b8137f9
    6 N65aa9e2136274f46900635b2f9480768
    7 N67a2947dd0724962ad47050b80e7d147
    8 N693952bda85842a6b3e132c163d0a346
    9 N828f6f7a6479423681567e295da61f3e
    10 Nb53c4c93d0fe41108ec4190429dc6ac7
    11 Nc06c037e888d492e85ed2576c5303903
    12 Nc3a06acbc3b046b2ac0f38b66774b11b
    13 Nc925b4042250491e8d02f0e2fec5184a
    14 Nda3e1f84a221463eab221ba9f2179ecd
    15 Ne21a62d3baeb42c282e6ca89e59e2ff3
    16 Ne5bd784aed344a6487607166d9c1fac7
    17 anzsrc-for:11
    18 anzsrc-for:1103
    19 schema:author Nb48fcffd6b6049e1ba54b828e1590687
    20 schema:citation sg:pub.10.1007/s00467-003-1175-4
    21 sg:pub.10.1007/s00467-004-1508-y
    22 sg:pub.10.1007/s00467-005-1964-z
    23 sg:pub.10.1007/s00467-008-0899-6
    24 sg:pub.10.1007/s00467-013-2553-1
    25 sg:pub.10.1007/s00467-014-3034-x
    26 sg:pub.10.1007/s004670050044
    27 sg:pub.10.1007/s004670050558
    28 sg:pub.10.1007/s004670100646
    29 sg:pub.10.1007/s10157-013-0856-y
    30 sg:pub.10.1007/s10157-014-1030-x
    31 schema:datePublished 2017-04-04
    32 schema:datePublishedReg 2017-04-04
    33 schema:description BackgroundSteroid-sparing drugs, such as cyclosporine, are recommended as treatment for children with frequently relapsing nephrotic syndrome (FRNS) and steroid-related toxicities. We recently reported a high rate of relapsing nephrotic syndrome 2 years after discontinuation of cyclosporine treatment, suggesting that long-term treatment is necessary. Cyclosporine-associated nephrotoxicity (CAN) is a potential side effect of long-term cyclosporine treatment.MethodsWe retrospectively reviewed pediatric patients with FRNS treated with cyclosporine for ≥3 years at a single center between 1999 and 2012. The cyclosporine dose was adjusted to maintain the whole-blood cyclosporine trough level at 80–100 ng/ml for 6 months, at 60–80 ng/ml for 18 months, and then at around 50–60 ng/ml thereafter. Maintenance dose of prednisolone was not prescribed. CAN was graded in terms of arteriolar hyalinosis and the degree of interstitial fibrosis.ResultsThirty-six children (28 males) were enrolled in the study. The median age at the start of long-term cyclosporine treatment was 9.4 years. The median duration of the longest period of cyclosporine treatment was 4.5 years. Most CAN cases were characterized by arteriolar hyalinosis. The frequency of CAN was positively correlated with the duration of cyclosporine treatment, with an odds ratio (95% confidence interval) for CAN of 3.84 (0.79–18.74) after 2–5 years and 6.60 (1.18–36.94) after >5 years of cyclosporine treatment (vs. 0–2 years).ConclusionsAlthough the frequency of CAN was correlated with the duration of cyclosporine treatment in our pediatric patient population, most cases of CAN involved arteriolar hyalinosis. We conclude that long-term cyclosporine treatment is useful for treating FRNS in children, providing its dose is controlled and kidney biopsies are regularly performed.
    34 schema:genre article
    35 schema:isAccessibleForFree false
    36 schema:isPartOf N2aac2ef77723420b9aad3fe684d15555
    37 Nea861fec2c9646b8a40760ee744295aa
    38 sg:journal.1097267
    39 schema:keywords BackgroundSteroids
    40 CAN cases
    41 ConclusionsAlthough
    42 FRNS
    43 MethodsWe
    44 age
    45 arteriolar hyalinosis
    46 biopsy
    47 cases
    48 center
    49 children
    50 cyclosporine
    51 cyclosporine dose
    52 cyclosporine treatment
    53 cyclosporine trough levels
    54 cyclosporine-associated nephrotoxicity
    55 degree
    56 discontinuation
    57 dose
    58 drugs
    59 duration
    60 effect
    61 fibrosis
    62 frequency
    63 high rate
    64 hyalinosis
    65 interstitial fibrosis
    66 kidney biopsy
    67 levels
    68 long period
    69 long-term cyclosporine treatment
    70 long-term treatment
    71 maintenance dose
    72 median age
    73 median duration
    74 months
    75 most cases
    76 nephrotic syndrome
    77 nephrotoxicity
    78 odds ratio
    79 patient population
    80 patients
    81 pediatric patient population
    82 pediatric patients
    83 period
    84 population
    85 potential side effects
    86 prednisolone
    87 rate
    88 ratio
    89 side effects
    90 single center
    91 start
    92 steroid-related toxicities
    93 study
    94 syndrome
    95 syndrome 2
    96 terms
    97 toxicity
    98 treatment
    99 trough levels
    100 years
    101 schema:name Nephrotoxicity in children with frequently relapsing nephrotic syndrome receiving long-term cyclosporine treatment
    102 schema:pagination 1383-1390
    103 schema:productId N0b76b908d8c84b409340900a39e7f126
    104 N1b23b3bc84fe481c8c495e19537b3dbb
    105 Nd4fb325d6d6b4c8c8b478d574feeb7f4
    106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084513328
    107 https://doi.org/10.1007/s00467-017-3641-4
    108 schema:sdDatePublished 2022-12-01T06:36
    109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    110 schema:sdPublisher N32031b52e552455d9aa34c99353c1440
    111 schema:url https://doi.org/10.1007/s00467-017-3641-4
    112 sgo:license sg:explorer/license/
    113 sgo:sdDataset articles
    114 rdf:type schema:ScholarlyArticle
    115 N0b56835b77744fb29ecdc8e8e9130c49 rdf:first sg:person.01112735663.13
    116 rdf:rest N88012b987ddf49c79d2ce8edff9b9c28
    117 N0b76b908d8c84b409340900a39e7f126 schema:name dimensions_id
    118 schema:value pub.1084513328
    119 rdf:type schema:PropertyValue
    120 N15f0a3fc80694a34855987efee7bf16c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Retrospective Studies
    122 rdf:type schema:DefinedTerm
    123 N1b23b3bc84fe481c8c495e19537b3dbb schema:name doi
    124 schema:value 10.1007/s00467-017-3641-4
    125 rdf:type schema:PropertyValue
    126 N1c2bc3e23ae54c7dbe653dbe3d91fb62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Adolescent
    128 rdf:type schema:DefinedTerm
    129 N2aac2ef77723420b9aad3fe684d15555 schema:issueNumber 8
    130 rdf:type schema:PublicationIssue
    131 N32031b52e552455d9aa34c99353c1440 schema:name Springer Nature - SN SciGraph project
    132 rdf:type schema:Organization
    133 N33ef7d482bc5484f9832f9d54169f6cc rdf:first sg:person.01300112777.86
    134 rdf:rest rdf:nil
    135 N38ce70ec8cb049b4b5d1788dc42c48a2 rdf:first sg:person.01033670077.45
    136 rdf:rest N89d7f926adb0481aa5bb34a247987d14
    137 N472f4a4453f34c10929e79f28f7cd6e1 rdf:first sg:person.01047135477.19
    138 rdf:rest N0b56835b77744fb29ecdc8e8e9130c49
    139 N476f87dc8f864920bc53780b25640133 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Child, Preschool
    141 rdf:type schema:DefinedTerm
    142 N54a7ac31feb74d9eb10478ae26791447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Female
    144 rdf:type schema:DefinedTerm
    145 N5905317f6a2f4d069265bf481b8137f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Nephrotic Syndrome
    147 rdf:type schema:DefinedTerm
    148 N658844beb6124a988ee5b43fcbb0097f rdf:first sg:person.01175526431.00
    149 rdf:rest N38ce70ec8cb049b4b5d1788dc42c48a2
    150 N65aa9e2136274f46900635b2f9480768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Cyclosporine
    152 rdf:type schema:DefinedTerm
    153 N67a2947dd0724962ad47050b80e7d147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Humans
    155 rdf:type schema:DefinedTerm
    156 N693952bda85842a6b3e132c163d0a346 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Glucocorticoids
    158 rdf:type schema:DefinedTerm
    159 N7e837f329a714fe686e531dda61ac496 rdf:first sg:person.01127413231.31
    160 rdf:rest N658844beb6124a988ee5b43fcbb0097f
    161 N828f6f7a6479423681567e295da61f3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Biopsy
    163 rdf:type schema:DefinedTerm
    164 N88012b987ddf49c79d2ce8edff9b9c28 rdf:first sg:person.0601607245.40
    165 rdf:rest N7e837f329a714fe686e531dda61ac496
    166 N89d7f926adb0481aa5bb34a247987d14 rdf:first sg:person.01237524620.30
    167 rdf:rest N33ef7d482bc5484f9832f9d54169f6cc
    168 Nb48fcffd6b6049e1ba54b828e1590687 rdf:first sg:person.01161051063.21
    169 rdf:rest N472f4a4453f34c10929e79f28f7cd6e1
    170 Nb53c4c93d0fe41108ec4190429dc6ac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Male
    172 rdf:type schema:DefinedTerm
    173 Nc06c037e888d492e85ed2576c5303903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Fibrosis
    175 rdf:type schema:DefinedTerm
    176 Nc3a06acbc3b046b2ac0f38b66774b11b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Maintenance Chemotherapy
    178 rdf:type schema:DefinedTerm
    179 Nc925b4042250491e8d02f0e2fec5184a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Prednisolone
    181 rdf:type schema:DefinedTerm
    182 Nd4fb325d6d6b4c8c8b478d574feeb7f4 schema:name pubmed_id
    183 schema:value 28378029
    184 rdf:type schema:PropertyValue
    185 Nda3e1f84a221463eab221ba9f2179ecd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Child
    187 rdf:type schema:DefinedTerm
    188 Ne21a62d3baeb42c282e6ca89e59e2ff3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Long-Term Care
    190 rdf:type schema:DefinedTerm
    191 Ne5bd784aed344a6487607166d9c1fac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Kidney
    193 rdf:type schema:DefinedTerm
    194 Nea861fec2c9646b8a40760ee744295aa schema:volumeNumber 32
    195 rdf:type schema:PublicationVolume
    196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    197 schema:name Medical and Health Sciences
    198 rdf:type schema:DefinedTerm
    199 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    200 schema:name Clinical Sciences
    201 rdf:type schema:DefinedTerm
    202 sg:grant.9341874 http://pending.schema.org/fundedItem sg:pub.10.1007/s00467-017-3641-4
    203 rdf:type schema:MonetaryGrant
    204 sg:journal.1097267 schema:issn 0931-041X
    205 1432-198X
    206 schema:name Pediatric Nephrology
    207 schema:publisher Springer Nature
    208 rdf:type schema:Periodical
    209 sg:person.01033670077.45 schema:affiliation grid-institutes:grid.417084.e
    210 schema:familyName Ogata
    211 schema:givenName Kentaro
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033670077.45
    213 rdf:type schema:Person
    214 sg:person.01047135477.19 schema:affiliation grid-institutes:None
    215 schema:familyName Komaki
    216 schema:givenName Fumiyo
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047135477.19
    218 rdf:type schema:Person
    219 sg:person.01112735663.13 schema:affiliation grid-institutes:grid.63906.3a
    220 schema:familyName Ishikura
    221 schema:givenName Kenji
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112735663.13
    223 rdf:type schema:Person
    224 sg:person.01127413231.31 schema:affiliation grid-institutes:grid.410827.8
    225 schema:familyName Sakai
    226 schema:givenName Tomoyuki
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127413231.31
    228 rdf:type schema:Person
    229 sg:person.01161051063.21 schema:affiliation grid-institutes:grid.417084.e
    230 schema:familyName Hamasaki
    231 schema:givenName Yuko
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161051063.21
    233 rdf:type schema:Person
    234 sg:person.01175526431.00 schema:affiliation grid-institutes:grid.417084.e
    235 schema:familyName Hataya
    236 schema:givenName Hiroshi
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175526431.00
    238 rdf:type schema:Person
    239 sg:person.01237524620.30 schema:affiliation grid-institutes:None
    240 schema:familyName Ando
    241 schema:givenName Takashi
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237524620.30
    243 rdf:type schema:Person
    244 sg:person.01300112777.86 schema:affiliation grid-institutes:grid.417084.e
    245 schema:familyName Honda
    246 schema:givenName Masataka
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300112777.86
    248 rdf:type schema:Person
    249 sg:person.0601607245.40 schema:affiliation grid-institutes:grid.417084.e
    250 schema:familyName Hamada
    251 schema:givenName Riku
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601607245.40
    253 rdf:type schema:Person
    254 sg:pub.10.1007/s00467-003-1175-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010530284
    255 https://doi.org/10.1007/s00467-003-1175-4
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/s00467-004-1508-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1033184947
    258 https://doi.org/10.1007/s00467-004-1508-y
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s00467-005-1964-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1044731039
    261 https://doi.org/10.1007/s00467-005-1964-z
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s00467-008-0899-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019693863
    264 https://doi.org/10.1007/s00467-008-0899-6
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s00467-013-2553-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009379940
    267 https://doi.org/10.1007/s00467-013-2553-1
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s00467-014-3034-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039114622
    270 https://doi.org/10.1007/s00467-014-3034-x
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s004670050044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003486257
    273 https://doi.org/10.1007/s004670050044
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/s004670050558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045165754
    276 https://doi.org/10.1007/s004670050558
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1007/s004670100646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053137495
    279 https://doi.org/10.1007/s004670100646
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s10157-013-0856-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1040454736
    282 https://doi.org/10.1007/s10157-013-0856-y
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1007/s10157-014-1030-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019458362
    285 https://doi.org/10.1007/s10157-014-1030-x
    286 rdf:type schema:CreativeWork
    287 grid-institutes:None schema:alternateName Department of Data Management, Japan Clinical Research Support Unit, Tokyo, Japan
    288 Division of Infectious Diseases Control, Health and Welfare Bureau Health Center of Kawasaki City, Kanagawa, Japan
    289 schema:name Department of Data Management, Japan Clinical Research Support Unit, Tokyo, Japan
    290 Division of Infectious Diseases Control, Health and Welfare Bureau Health Center of Kawasaki City, Kanagawa, Japan
    291 rdf:type schema:Organization
    292 grid-institutes:grid.410827.8 schema:alternateName Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
    293 schema:name Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
    294 rdf:type schema:Organization
    295 grid-institutes:grid.417084.e schema:alternateName Department of Nephrology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
    296 Department of Pathology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
    297 schema:name Department of Nephrology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
    298 Department of Pathology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
    299 Department of Pediatric Nephrology, Faculty of Medicine, Toho University, 6-11-1 Omori-Nishi, Ota-Ku, 143-8541, Tokyo, Japan
    300 rdf:type schema:Organization
    301 grid-institutes:grid.63906.3a schema:alternateName Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan
    302 schema:name Department of Nephrology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
    303 Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan
    304 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...