Association of C1q-fixing DSA with late graft failure in pediatric renal transplant recipients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02-29

AUTHORS

Alexander Fichtner, Caner Süsal, Britta Höcker, Susi Rieger, Rüdiger Waldherr, Jens H Westhoff, Anja Sander, Gerhard Opelz, Burkhard Tönshoff

ABSTRACT

BackgroundWe investigated the prognostic value of overall and complement-binding donor-specific HLA antibodies (DSA) in pediatric patients undergoing clinically indicated graft biopsies and their association with graft outcome and specific histological lesions.MethodsSera of 62 patients at time of indication biopsy ≥1 year posttransplant were assessed for DSA and C1q-fixing DSA by single-antigen bead (SAB) technology.ResultsTwenty-six patients (42 %) were DSA-positive at time of indication biopsy and nine (15 %) were C1q-positive. At 4 years postbiopsy, patients with C1q-positivity had a low graft survival (11 %) compared to DSA-positive, C1q-negative patients (82 %, p = 0.001) and to DSA-negative patients (88 %, p < 0.001). The majority (89 %) of C1q-positive patients were diagnosed with active chronic antibody-mediated rejection (ABMR). C1q DSA-positivity [adjusted hazard ratio (HR) 6.35], presence of transplant glomerulopathy (HR 9.54), and estimated glomerular filtration rate (eGFR) at the time of indication biopsy (HR 0.91) were risk factors for subsequent graft loss.ConclusionsThe presence of C1q-positive DSA in the context of an indication biopsy identifies a subgroup of pediatric renal transplant recipients with a markedly increased risk of subsequent graft loss. Because a fraction of DSA-positive patients escape rejection or graft dysfunction, the C1q assay increases the specificity of a positive DSA result regarding unfavorable transplant outcome. More... »

PAGES

1157-1166

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-016-3322-8

DOI

http://dx.doi.org/10.1007/s00467-016-3322-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040045817

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26928311


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement C1q", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft Rejection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplant Recipients", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fichtner", 
        "givenName": "Alexander", 
        "id": "sg:person.0634572435.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634572435.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00fcsal", 
        "givenName": "Caner", 
        "id": "sg:person.0762750410.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762750410.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f6cker", 
        "givenName": "Britta", 
        "id": "sg:person.01113416771.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113416771.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rieger", 
        "givenName": "Susi", 
        "id": "sg:person.014024326677.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014024326677.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Pathology Heidelberg, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Clinical Pathology Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waldherr", 
        "givenName": "R\u00fcdiger", 
        "id": "sg:person.01041273513.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041273513.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westhoff", 
        "givenName": "Jens H", 
        "id": "sg:person.01234721075.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234721075.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sander", 
        "givenName": "Anja", 
        "id": "sg:person.01266744035.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266744035.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Opelz", 
        "givenName": "Gerhard", 
        "id": "sg:person.01227377470.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227377470.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "T\u00f6nshoff", 
        "givenName": "Burkhard", 
        "id": "sg:person.0740557371.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740557371.53"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2016-02-29", 
    "datePublishedReg": "2016-02-29", 
    "description": "BackgroundWe investigated the prognostic value of overall and complement-binding donor-specific HLA antibodies (DSA) in pediatric patients undergoing clinically indicated graft biopsies and their association with graft outcome and specific histological lesions.MethodsSera of 62 patients at time of indication biopsy \u22651\u00a0year posttransplant were assessed for DSA and C1q-fixing DSA by single-antigen bead (SAB) technology.ResultsTwenty-six patients (42\u00a0%) were DSA-positive at time of indication biopsy and nine (15\u00a0%) were C1q-positive. At 4\u00a0years postbiopsy, patients with C1q-positivity had a low graft survival (11\u00a0%) compared to DSA-positive, C1q-negative patients (82\u00a0%, p\u2009=\u20090.001) and to DSA-negative patients (88\u00a0%, p\u2009<\u20090.001). The majority (89\u00a0%) of C1q-positive patients were diagnosed with active chronic antibody-mediated rejection (ABMR). C1q DSA-positivity [adjusted hazard ratio (HR) 6.35], presence of transplant glomerulopathy (HR 9.54), and estimated glomerular filtration rate (eGFR) at the time of indication biopsy (HR 0.91) were risk factors for subsequent graft loss.ConclusionsThe presence of C1q-positive DSA in the context of an indication biopsy identifies a subgroup of pediatric renal transplant recipients with a markedly increased risk of subsequent graft loss. Because a fraction of DSA-positive patients escape rejection or graft dysfunction, the C1q assay increases the specificity of a positive DSA result regarding unfavorable transplant outcome.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00467-016-3322-8", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097267", 
        "issn": [
          "0931-041X", 
          "1432-198X"
        ], 
        "name": "Pediatric Nephrology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "keywords": [
      "donor-specific HLA antibodies", 
      "pediatric renal transplant recipients", 
      "subsequent graft loss", 
      "renal transplant recipients", 
      "indication biopsies", 
      "graft loss", 
      "transplant recipients", 
      "chronic antibody-mediated rejection", 
      "single-antigen bead technology", 
      "C1q-negative patients", 
      "DSA-negative patients", 
      "C1q-positive patients", 
      "DSA-positive patients", 
      "ResultsTwenty-six patients", 
      "lower graft survival", 
      "antibody-mediated rejection", 
      "glomerular filtration rate", 
      "late graft failure", 
      "specific histological lesions", 
      "graft biopsy", 
      "year posttransplant", 
      "C1q positivity", 
      "DSA positivity", 
      "graft dysfunction", 
      "HLA antibodies", 
      "graft outcome", 
      "graft survival", 
      "transplant glomerulopathy", 
      "transplant outcomes", 
      "graft failure", 
      "pediatric patients", 
      "prognostic value", 
      "filtration rate", 
      "risk factors", 
      "histological lesions", 
      "patients", 
      "biopsy", 
      "ConclusionsThe presence", 
      "C1q", 
      "association of C1q", 
      "DSA results", 
      "recipients", 
      "outcomes", 
      "bead technology", 
      "association", 
      "MethodsSera", 
      "posttransplant", 
      "postbiopsy", 
      "glomerulopathy", 
      "BackgroundWe", 
      "dysfunction", 
      "lesions", 
      "rejection", 
      "antibodies", 
      "survival", 
      "subgroups", 
      "risk", 
      "loss", 
      "failure", 
      "majority", 
      "presence", 
      "specificity", 
      "time", 
      "factors", 
      "rate", 
      "fraction", 
      "results", 
      "identifies", 
      "values", 
      "context", 
      "technology"
    ], 
    "name": "Association of C1q-fixing DSA with late graft failure in pediatric renal transplant recipients", 
    "pagination": "1157-1166", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040045817"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00467-016-3322-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26928311"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00467-016-3322-8", 
      "https://app.dimensions.ai/details/publication/pub.1040045817"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_686.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00467-016-3322-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00467-016-3322-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00467-016-3322-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00467-016-3322-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00467-016-3322-8'


 

This table displays all metadata directly associated to this object as RDF triples.

260 TRIPLES      20 PREDICATES      112 URIs      104 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00467-016-3322-8 schema:about N015156f352b442878d326e4039ee51ae
2 N015f77ab15834012a86dfe3563d84ef6
3 N0647ed2cc3e044de84d03569593d3cb8
4 N09da6263632745408ccccaf7255df7c2
5 N1adcd6318b764a90952228cd900d76ca
6 N2eb6829d84d14029a646d22bc6508046
7 N4346850fc30948899f56935230adc99d
8 N4c4942f2f0ee40acb78b34e942a9402b
9 N53677018e2d04dddbae18a964e2c78d9
10 N5ba1eb11eb044084bcb0de26f2932dfc
11 N6ebf1d0a9a0d4742951c92222d9ff4e6
12 N8fc4e6c69819443b92d2d91b60f7609a
13 Naa7153003b7e4394a95901606a5ce491
14 Ne18627a666d74dc0a881e200bf981e22
15 Nea83f612259a49d485bacc15b7aa8407
16 Nedc78d88066e4e9ca959d08e40cbed03
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author N2e0afec43823444caca589d8bbb2f2f4
20 schema:datePublished 2016-02-29
21 schema:datePublishedReg 2016-02-29
22 schema:description BackgroundWe investigated the prognostic value of overall and complement-binding donor-specific HLA antibodies (DSA) in pediatric patients undergoing clinically indicated graft biopsies and their association with graft outcome and specific histological lesions.MethodsSera of 62 patients at time of indication biopsy ≥1 year posttransplant were assessed for DSA and C1q-fixing DSA by single-antigen bead (SAB) technology.ResultsTwenty-six patients (42 %) were DSA-positive at time of indication biopsy and nine (15 %) were C1q-positive. At 4 years postbiopsy, patients with C1q-positivity had a low graft survival (11 %) compared to DSA-positive, C1q-negative patients (82 %, p = 0.001) and to DSA-negative patients (88 %, p < 0.001). The majority (89 %) of C1q-positive patients were diagnosed with active chronic antibody-mediated rejection (ABMR). C1q DSA-positivity [adjusted hazard ratio (HR) 6.35], presence of transplant glomerulopathy (HR 9.54), and estimated glomerular filtration rate (eGFR) at the time of indication biopsy (HR 0.91) were risk factors for subsequent graft loss.ConclusionsThe presence of C1q-positive DSA in the context of an indication biopsy identifies a subgroup of pediatric renal transplant recipients with a markedly increased risk of subsequent graft loss. Because a fraction of DSA-positive patients escape rejection or graft dysfunction, the C1q assay increases the specificity of a positive DSA result regarding unfavorable transplant outcome.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf N35e2e48019064d04a20596bad6da72b6
26 Nbaaaa5df84094ff481343f7392641e7b
27 sg:journal.1097267
28 schema:keywords BackgroundWe
29 C1q
30 C1q positivity
31 C1q-negative patients
32 C1q-positive patients
33 ConclusionsThe presence
34 DSA positivity
35 DSA results
36 DSA-negative patients
37 DSA-positive patients
38 HLA antibodies
39 MethodsSera
40 ResultsTwenty-six patients
41 antibodies
42 antibody-mediated rejection
43 association
44 association of C1q
45 bead technology
46 biopsy
47 chronic antibody-mediated rejection
48 context
49 donor-specific HLA antibodies
50 dysfunction
51 factors
52 failure
53 filtration rate
54 fraction
55 glomerular filtration rate
56 glomerulopathy
57 graft biopsy
58 graft dysfunction
59 graft failure
60 graft loss
61 graft outcome
62 graft survival
63 histological lesions
64 identifies
65 indication biopsies
66 late graft failure
67 lesions
68 loss
69 lower graft survival
70 majority
71 outcomes
72 patients
73 pediatric patients
74 pediatric renal transplant recipients
75 postbiopsy
76 posttransplant
77 presence
78 prognostic value
79 rate
80 recipients
81 rejection
82 renal transplant recipients
83 results
84 risk
85 risk factors
86 single-antigen bead technology
87 specific histological lesions
88 specificity
89 subgroups
90 subsequent graft loss
91 survival
92 technology
93 time
94 transplant glomerulopathy
95 transplant outcomes
96 transplant recipients
97 values
98 year posttransplant
99 schema:name Association of C1q-fixing DSA with late graft failure in pediatric renal transplant recipients
100 schema:pagination 1157-1166
101 schema:productId N48b579878c06445ab172f205fbc986a0
102 N5dc54e4d174c429b8337700eca12646d
103 Ned0b089567374ee79f5ecf111dd55f39
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040045817
105 https://doi.org/10.1007/s00467-016-3322-8
106 schema:sdDatePublished 2022-12-01T06:34
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N00e74dd356944d0a90e035696a3f9760
109 schema:url https://doi.org/10.1007/s00467-016-3322-8
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N00e74dd356944d0a90e035696a3f9760 schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 N015156f352b442878d326e4039ee51ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Kidney Transplantation
117 rdf:type schema:DefinedTerm
118 N015f77ab15834012a86dfe3563d84ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Adolescent
120 rdf:type schema:DefinedTerm
121 N0647ed2cc3e044de84d03569593d3cb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Antibodies
123 rdf:type schema:DefinedTerm
124 N09da6263632745408ccccaf7255df7c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Transplant Recipients
126 rdf:type schema:DefinedTerm
127 N0e97aabb27494cf3992d696c79056685 rdf:first sg:person.01113416771.47
128 rdf:rest Nbf5394e55a59486c9bc86661954e6e36
129 N1adcd6318b764a90952228cd900d76ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Retrospective Studies
131 rdf:type schema:DefinedTerm
132 N2e0afec43823444caca589d8bbb2f2f4 rdf:first sg:person.0634572435.58
133 rdf:rest N9ca9e3ab1e8049af953f52339a778667
134 N2eb6829d84d14029a646d22bc6508046 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Male
136 rdf:type schema:DefinedTerm
137 N35e2e48019064d04a20596bad6da72b6 schema:volumeNumber 31
138 rdf:type schema:PublicationVolume
139 N4346850fc30948899f56935230adc99d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Complement Activation
141 rdf:type schema:DefinedTerm
142 N48b579878c06445ab172f205fbc986a0 schema:name pubmed_id
143 schema:value 26928311
144 rdf:type schema:PropertyValue
145 N492f813f1f8a4eb6bfab895af5777c51 rdf:first sg:person.01234721075.30
146 rdf:rest Nb0445cadb48a4e4dad0193bf2ce62f68
147 N4c4942f2f0ee40acb78b34e942a9402b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cohort Studies
149 rdf:type schema:DefinedTerm
150 N53677018e2d04dddbae18a964e2c78d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Prognosis
152 rdf:type schema:DefinedTerm
153 N5ba1eb11eb044084bcb0de26f2932dfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Complement C1q
155 rdf:type schema:DefinedTerm
156 N5dc54e4d174c429b8337700eca12646d schema:name doi
157 schema:value 10.1007/s00467-016-3322-8
158 rdf:type schema:PropertyValue
159 N6ebf1d0a9a0d4742951c92222d9ff4e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Graft Rejection
161 rdf:type schema:DefinedTerm
162 N8fc4e6c69819443b92d2d91b60f7609a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Child
164 rdf:type schema:DefinedTerm
165 N9003c5c1606f4a0589c348fedcf123ef rdf:first sg:person.01227377470.55
166 rdf:rest N9956d28f509442bb9f681b638e0bcf24
167 N9956d28f509442bb9f681b638e0bcf24 rdf:first sg:person.0740557371.53
168 rdf:rest rdf:nil
169 N9ca9e3ab1e8049af953f52339a778667 rdf:first sg:person.0762750410.13
170 rdf:rest N0e97aabb27494cf3992d696c79056685
171 Naa7153003b7e4394a95901606a5ce491 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Humans
173 rdf:type schema:DefinedTerm
174 Nb0445cadb48a4e4dad0193bf2ce62f68 rdf:first sg:person.01266744035.53
175 rdf:rest N9003c5c1606f4a0589c348fedcf123ef
176 Nbaaaa5df84094ff481343f7392641e7b schema:issueNumber 7
177 rdf:type schema:PublicationIssue
178 Nbf5394e55a59486c9bc86661954e6e36 rdf:first sg:person.014024326677.87
179 rdf:rest Nc70b1a4a1e9e461a89932770ecf199d0
180 Nc70b1a4a1e9e461a89932770ecf199d0 rdf:first sg:person.01041273513.06
181 rdf:rest N492f813f1f8a4eb6bfab895af5777c51
182 Ne18627a666d74dc0a881e200bf981e22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Female
184 rdf:type schema:DefinedTerm
185 Nea83f612259a49d485bacc15b7aa8407 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Enzyme-Linked Immunosorbent Assay
187 rdf:type schema:DefinedTerm
188 Ned0b089567374ee79f5ecf111dd55f39 schema:name dimensions_id
189 schema:value pub.1040045817
190 rdf:type schema:PropertyValue
191 Nedc78d88066e4e9ca959d08e40cbed03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name HLA Antigens
193 rdf:type schema:DefinedTerm
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
198 schema:name Immunology
199 rdf:type schema:DefinedTerm
200 sg:journal.1097267 schema:issn 0931-041X
201 1432-198X
202 schema:name Pediatric Nephrology
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.01041273513.06 schema:affiliation grid-institutes:None
206 schema:familyName Waldherr
207 schema:givenName Rüdiger
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041273513.06
209 rdf:type schema:Person
210 sg:person.01113416771.47 schema:affiliation grid-institutes:grid.5253.1
211 schema:familyName Höcker
212 schema:givenName Britta
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113416771.47
214 rdf:type schema:Person
215 sg:person.01227377470.55 schema:affiliation grid-institutes:grid.7700.0
216 schema:familyName Opelz
217 schema:givenName Gerhard
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227377470.55
219 rdf:type schema:Person
220 sg:person.01234721075.30 schema:affiliation grid-institutes:grid.5253.1
221 schema:familyName Westhoff
222 schema:givenName Jens H
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234721075.30
224 rdf:type schema:Person
225 sg:person.01266744035.53 schema:affiliation grid-institutes:grid.7700.0
226 schema:familyName Sander
227 schema:givenName Anja
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266744035.53
229 rdf:type schema:Person
230 sg:person.014024326677.87 schema:affiliation grid-institutes:grid.5253.1
231 schema:familyName Rieger
232 schema:givenName Susi
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014024326677.87
234 rdf:type schema:Person
235 sg:person.0634572435.58 schema:affiliation grid-institutes:grid.5253.1
236 schema:familyName Fichtner
237 schema:givenName Alexander
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634572435.58
239 rdf:type schema:Person
240 sg:person.0740557371.53 schema:affiliation grid-institutes:grid.5253.1
241 schema:familyName Tönshoff
242 schema:givenName Burkhard
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740557371.53
244 rdf:type schema:Person
245 sg:person.0762750410.13 schema:affiliation grid-institutes:grid.7700.0
246 schema:familyName Süsal
247 schema:givenName Caner
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762750410.13
249 rdf:type schema:Person
250 grid-institutes:None schema:alternateName Institute of Clinical Pathology Heidelberg, Heidelberg, Germany
251 schema:name Institute of Clinical Pathology Heidelberg, Heidelberg, Germany
252 rdf:type schema:Organization
253 grid-institutes:grid.5253.1 schema:alternateName Department of Pediatrics I, University Children’s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany
254 schema:name Department of Pediatrics I, University Children’s Hospital Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany
255 rdf:type schema:Organization
256 grid-institutes:grid.7700.0 schema:alternateName Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
257 Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany
258 schema:name Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
259 Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany
260 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...