Insignificant impact of VUR on the progression of CKD in children with CAKUT View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09-24

AUTHORS

Kenji Ishikura, Osamu Uemura, Yuko Hamasaki, Hideo Nakai, Shuichi Ito, Ryoko Harada, Motoshi Hattori, Yasuo Ohashi, Ryojiro Tanaka, Koichi Nakanishi, Tetsuji Kaneko, Kazumoto Iijima, Masataka Honda, on behalf of the Pediatric CKD Study Group in Japan in conjunction with the Committee of Measures for Pediatric CKD of the Japanese Society for Pediatric Nephrology

ABSTRACT

BackgroundVesicoureteral reflux (VUR) is associated with an increased risk of kidney disorders. It is unclear whether VUR is associated with progression from chronic kidney disease (CKD) to end-stage kidney disease (ESKD) in children with congenital anomalies of the kidney and urinary tract (CAKUT).MethodsWe conducted a 3-year follow-up survey of a cohort of 447 children with CKD (stage 3–5). Rates of and risk factors for progression to ESKD were determined using the Kaplan–Meier method and Cox regression respectively.ResultsCongenital anomaly of the kidney and urinary tract was the primary etiology in 278 out of 447 children; 118 (42.4 %) had a history of VUR at the start of the cohort study. There were significantly more boys than girls with VUR, whereas the proportions were similar in children without VUR. The types of urinary anomalies/complications of the two groups were significantly different. Three-year renal survival rates of the groups were not significantly different, irrespective of CKD stage. Age < 2 years and age after puberty, stage 4 or 5 CKD, and heavy proteinuria, but not history of VUR, were significantly associated with progression to ESKD.ConclusionsHistory of VUR at the start of follow-up was not associated with the progression of stage 3–5 CKD in children with CAKUT. More... »

PAGES

105-112

References to SciGraph publications

Journal

TITLE

Pediatric Nephrology

ISSUE

1

VOLUME

31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-015-3196-1

DOI

http://dx.doi.org/10.1007/s00467-015-3196-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025057244

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26404649


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36 schema:description BackgroundVesicoureteral reflux (VUR) is associated with an increased risk of kidney disorders. It is unclear whether VUR is associated with progression from chronic kidney disease (CKD) to end-stage kidney disease (ESKD) in children with congenital anomalies of the kidney and urinary tract (CAKUT).MethodsWe conducted a 3-year follow-up survey of a cohort of 447 children with CKD (stage 3–5). Rates of and risk factors for progression to ESKD were determined using the Kaplan–Meier method and Cox regression respectively.ResultsCongenital anomaly of the kidney and urinary tract was the primary etiology in 278 out of 447 children; 118 (42.4 %) had a history of VUR at the start of the cohort study. There were significantly more boys than girls with VUR, whereas the proportions were similar in children without VUR. The types of urinary anomalies/complications of the two groups were significantly different. Three-year renal survival rates of the groups were not significantly different, irrespective of CKD stage. Age  < 2 years and age after puberty, stage 4 or 5 CKD, and heavy proteinuria, but not history of VUR, were significantly associated with progression to ESKD.ConclusionsHistory of VUR at the start of follow-up was not associated with the progression of stage 3–5 CKD in children with CAKUT.
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42 schema:keywords BackgroundVesicoureteral reflux
43 CAKUT
44 CKD stage
45 ConclusionsHistory
46 Cox regression
47 Kaplan-Meier method
48 MethodsWe
49 VUR
50 age
51 anomalies
52 boys
53 children
54 chronic kidney disease
55 cohort
56 cohort study
57 complications
58 congenital anomalies
59 disease
60 disorders
61 end-stage kidney disease
62 etiology
63 factors
64 follow
65 girls
66 group
67 heavy proteinuria
68 history
69 impact
70 insignificant impact
71 kidney
72 kidney disease
73 kidney disorders
74 method
75 more boys
76 primary etiology
77 progression
78 progression of CKD
79 proportion
80 proteinuria
81 puberty
82 rate
83 reflux
84 regression
85 renal survival rate
86 risk
87 risk factors
88 stage
89 stage 3
90 stage 4
91 start
92 study
93 survey
94 survival rate
95 tract
96 types
97 urinary tract
98 years
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