Early and frequent development of ocular hypertension in children with nephrotic syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05-24

AUTHORS

Emi Kawaguchi, Kenji Ishikura, Riku Hamada, Yoshinobu Nagaoka, Yoshihiko Morikawa, Tomoyuki Sakai, Yuko Hamasaki, Hiroshi Hataya, Eiichiro Noda, Masaru Miura, Takashi Ando, Masataka Honda

ABSTRACT

BackgroundPrednisolone, the first-line treatment for children with nephrotic syndrome, causes severe side effects. One of these side effects is ocular hypertension, which can result in severe and permanent visual disturbance. However, the exact prevalence, severity and timing of development of ocular hypertension have yet to be fully explored in this pediatric patient group.MethodsIn this retrospective cohort study, children with nephrotic syndrome treated with prednisolone for their first episode were analyzed. Intraocular pressure was screened with an iCare® tonometer and confirmed with Goldmann applanation tonometry before the initiation of prednisolone treatment and at 1 and 4 weeks thereafter.ResultsA total of 26 children with nephrotic syndrome were included in this study, of whom eight (30.8 %) required treatment with eye drops for ocular hypertension. The median time interval between the diagnosis of ocular hypertension and start of treatment was 9 (range 5–31) days. At relapse of nephrotic syndrome, all children who had undergone treatment for ocular hypertension in their first episode again required treatment for ocular hypertension.ConclusionsRoutine ophthalmologic examination should be conducted from the early phase after the start of prednisolone treatment. In addition, children with episodes of ocular hypertension may be at greater risk of its reappearance with relapse of the nephrotic syndrome. More... »

PAGES

2165-2171

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-014-2848-x

DOI

http://dx.doi.org/10.1007/s00467-014-2848-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027648715

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24859790


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