Lipopolysaccharide-binding protein: a potential marker of febrile urinary tract infection in childhood View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-03-06

AUTHORS

Evanthia A. Tsalkidou, Emmanouel Roilides, Stefanos Gardikis, Gregory Trypsianis, Alexandros Kortsaris, Athanasios Chatzimichael, Ioannis Tentes

ABSTRACT

BackgroundUrinary tract infections (UTIs) are encountered frequently in children, and their early diagnosis and treatment are important. This study evaluates the diagnostic value of serum concentrations of lipopolysaccharide-binding protein (LBP), an acute-phase protein, in children with febrile UTI and compares it to those of the total white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6).MethodsThe study population comprised 77 consecutive patients with a first-episode febrile UTI (33 boys) with a median age of 11 months [interquartile range (IQR), 5.5–33 months], 21 healthy controls (11 boys) with a median age of 10 months (IQR, 5–20.5 months) and 58 febrile controls with a fever due to other causes (28 boys) with a median age of 12.5 months (IQR, 7–30 months). LBP, IL-6, PCT, and CRP were measured for both patients and control groups.ResultsThe serum levels of LBP (p < 0.001), CRP (p < 0.001), PCT (p = 0.001), IL-6 (p = 0.002), ESR (p = 0.020), and WBC (p < 0.001) were higher in patients with febrile UTI than in the healthy and febrile control groups. The LPB cut-off value for best sensitivity and specificity in patients with febrile UTI was >43.23 mg/l. Furthermore, the area under the receiver operating characteristic curve was significantly greater for LBP than for CRP (p = 0.014), PCT (p < 0.001), ESR (p < 0.001), WBC (p = 0.002) and IL-6 (p = 0.006).ConclusionsThe results of this study suggest that the serum LBP concentration constitutes a reliable biologic marker for the diagnosis of a febrile UTI in children. More... »

PAGES

1091-1097

Journal

TITLE

Pediatric Nephrology

ISSUE

7

VOLUME

28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-013-2432-9

DOI

http://dx.doi.org/10.1007/s00467-013-2432-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041490403

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23463341


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40 schema:description BackgroundUrinary tract infections (UTIs) are encountered frequently in children, and their early diagnosis and treatment are important. This study evaluates the diagnostic value of serum concentrations of lipopolysaccharide-binding protein (LBP), an acute-phase protein, in children with febrile UTI and compares it to those of the total white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6).MethodsThe study population comprised 77 consecutive patients with a first-episode febrile UTI (33 boys) with a median age of 11 months [interquartile range (IQR), 5.5–33 months], 21 healthy controls (11 boys) with a median age of 10 months (IQR, 5–20.5 months) and 58 febrile controls with a fever due to other causes (28 boys) with a median age of 12.5 months (IQR, 7–30 months). LBP, IL-6, PCT, and CRP were measured for both patients and control groups.ResultsThe serum levels of LBP (p  <  0.001), CRP (p  <  0.001), PCT (p  =  0.001), IL-6 (p  =  0.002), ESR (p  =  0.020), and WBC (p  <  0.001) were higher in patients with febrile UTI than in the healthy and febrile control groups. The LPB cut-off value for best sensitivity and specificity in patients with febrile UTI was >43.23 mg/l. Furthermore, the area under the receiver operating characteristic curve was significantly greater for LBP than for CRP (p  =  0.014), PCT (p  <  0.001), ESR (p  <  0.001), WBC (p  =  0.002) and IL-6 (p  =  0.006).ConclusionsThe results of this study suggest that the serum LBP concentration constitutes a reliable biologic marker for the diagnosis of a febrile UTI in children.
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46 schema:keywords BackgroundUrinary tract infection
47 C-reactive protein
48 ConclusionsThe results
49 LBP concentrations
50 LPB
51 MethodsThe study population
52 Serum LBP concentrations
53 UTI
54 acute phase proteins
55 age
56 area
57 biologic markers
58 blood cell count
59 cause
60 cell count
61 characteristic curve
62 childhood
63 children
64 concentration
65 consecutive patients
66 control
67 control group
68 count
69 curves
70 diagnosis
71 diagnostic value
72 early diagnosis
73 erythrocyte sedimentation rate
74 febrile UTI
75 febrile control group
76 febrile controls
77 febrile urinary tract infection
78 fever
79 good sensitivity
80 group
81 healthy controls
82 infection
83 interleukin-6
84 levels
85 lipopolysaccharide-binding protein
86 markers
87 median age
88 months
89 patients
90 population
91 potential marker
92 procalcitonin
93 protein
94 rate
95 receiver
96 reliable biologic marker
97 results
98 sedimentation rate
99 sensitivity
100 serum concentrations
101 serum levels
102 specificity
103 study
104 study population
105 total white blood cell count
106 tract infections
107 treatment
108 urinary tract infection
109 values
110 white blood cell count
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