Late recovery of renal function by rituximab in a patient with Wegener’s granulomatosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-11-06

AUTHORS

Michal Malina, Betti Schaefer, Rüdiger Waldherr, Elke Wühl, Franz Schaefer, Claus Peter Schmitt

ABSTRACT

BackgroundRituximab has proven effective in the treatment of complicated granulomatosis with polyangiitis (Wegener’s, GPA). Two controlled trials in adults demonstrated beneficial effects of rituximab compared to cyclophosphamide in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis to induce remission and to treat relapses. Pediatric experience with rituximab in GPA is limited; the impact on renal function is unknown.Case-diagnosis/treatmentWe report a female adolescent with GPA and necrotizing glomerulonephritis that lead to end-stage renal disease (ESRD). After 22 months of peritoneal dialysis, she still experienced relapses and major treatment-associated adverse effects. After a single dose of rituximab, she rapidly achieved clinical remission and, unexpectedly, steadily recovered glomerular filtration rate, plateauing at 25 ml/min/1.73 m2. Peritoneal dialysis could be discontinued for 16 months.ConclusionsThis case documents a potent beneficial effect of rituximab on renal manifestation of GPA even in long-established ESRD. More... »

PAGES

511-514

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-012-2332-4

DOI

http://dx.doi.org/10.1007/s00467-012-2332-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012671785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23124537


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