Maintenance therapy with mycophenolate mofetil after rituximab in pediatric patients with steroid-dependent nephrotic syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10

AUTHORS

Shuichi Ito, Koichi Kamei, Masao Ogura, Mai Sato, Takuya Fujimaru, Tomoaki Ishikawa, Tomohiro Udagawa, Kazumoto Iijima

ABSTRACT

Rituximab (RTX) has a significant steroid-sparing effect in children with steroid-dependent nephrotic syndrome (SDNS). However, patients are likely to relapse with the recovery of CD20+ cells. We conducted a small prospective cohort study with a historical control to evaluate the effect of RTX infusion followed by mycophenolate mofetil (MMF) as a maintenance therapy. Nine patients with SDNS who stopped their steroid treatment but were treated with MMF after RTX infusion were prospectively observed (group A). Seven patients with SDNS who discontinued steroid and immunosuppressive agents after RTX administration served as a control (group B). During the first year after the administration of RTX, six patients in group A and one patient in group B did not suffer a relapse (p < 0.05). The number of patients who relapsed during the 1 year preceding RTX treatment did not differ between the two groups [4.1 (A) vs. 5.7 (B)], but it was significantly lower in the MMF-treated group 1 year after the RTX treatment [0.4 (A) vs. 2.3 (B), p < 0.005]. The daily amount of prednisolone after the RTX treatment was lower in group A than in group B (0.11 vs. 0.46 mg/kg/day, respectively; p < 0.05). Three patients in group A and five patients in group B relapsed to SDNS and needed additional RTX treatment(s) within 1 year (odds ratio 5.0). Based on these results, we conclude that maintenance therapy with MMF after RTX is a good clinical option. More... »

PAGES

1823-1828

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-011-1886-x

DOI

http://dx.doi.org/10.1007/s00467-011-1886-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038755333

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21556716


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Murine-Derived", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD20", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunosuppressive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mycophenolic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephrotic Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prednisolone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rituximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Secondary Prevention", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Steroids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, 157-8535, Setagaya-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Shuichi", 
        "id": "sg:person.012302533312.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012302533312.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, 157-8535, Setagaya-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamei", 
        "givenName": "Koichi", 
        "id": "sg:person.01316365041.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316365041.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, 157-8535, Setagaya-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogura", 
        "givenName": "Masao", 
        "id": "sg:person.01174574062.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174574062.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, 157-8535, Setagaya-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Mai", 
        "id": "sg:person.01060345462.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060345462.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, 157-8535, Setagaya-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujimaru", 
        "givenName": "Takuya", 
        "id": "sg:person.0622744202.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622744202.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, 157-8535, Setagaya-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishikawa", 
        "givenName": "Tomoaki", 
        "id": "sg:person.015327457417.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015327457417.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, 157-8535, Setagaya-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Udagawa", 
        "givenName": "Tomohiro", 
        "id": "sg:person.01267226363.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267226363.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kobe University", 
          "id": "https://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Pediatrics, School of Medicine, Kobe University, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iijima", 
        "givenName": "Kazumoto", 
        "id": "sg:person.01360637141.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360637141.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00467-006-0294-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001089825", 
          "https://doi.org/10.1007/s00467-006-0294-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-006-0294-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001089825", 
          "https://doi.org/10.1007/s00467-006-0294-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2002.00303.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002280019", 
          "https://doi.org/10.1046/j.1523-1755.2002.00303.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-010-1465-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013692046", 
          "https://doi.org/10.1007/s00467-010-1465-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-010-1465-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013692046", 
          "https://doi.org/10.1007/s00467-010-1465-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-0899-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019693863", 
          "https://doi.org/10.1007/s00467-008-0899-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3476(81)80760-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022626465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1377-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022984402", 
          "https://doi.org/10.1007/s00467-009-1377-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1377-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022984402", 
          "https://doi.org/10.1007/s00467-009-1377-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-10-186999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023377809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1195-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028250994", 
          "https://doi.org/10.1007/s00467-009-1195-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1195-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028250994", 
          "https://doi.org/10.1007/s00467-009-1195-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1195-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028250994", 
          "https://doi.org/10.1007/s00467-009-1195-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.05691108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031173083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.00550206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031234598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ppul.20864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032788189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ppul.20864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032788189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(81)92348-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033459468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(81)92348-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033459468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-1030-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034882908", 
          "https://doi.org/10.1007/s00467-008-1030-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-1030-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034882908", 
          "https://doi.org/10.1007/s00467-008-1030-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-004-1434-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034927167", 
          "https://doi.org/10.1007/s00467-004-1434-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-005-2013-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045340328", 
          "https://doi.org/10.1007/s00467-005-2013-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-005-2013-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045340328", 
          "https://doi.org/10.1007/s00467-005-2013-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-0814-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047664910", 
          "https://doi.org/10.1007/s00467-008-0814-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-0814-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047664910", 
          "https://doi.org/10.1007/s00467-008-0814-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1191-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052697168", 
          "https://doi.org/10.1007/s00467-009-1191-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1191-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052697168", 
          "https://doi.org/10.1007/s00467-009-1191-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1191-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052697168", 
          "https://doi.org/10.1007/s00467-009-1191-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-10", 
    "datePublishedReg": "2011-10-01", 
    "description": "Rituximab (RTX) has a significant steroid-sparing effect in children with steroid-dependent nephrotic syndrome (SDNS). However, patients are likely to relapse with the recovery of CD20+ cells. We conducted a small prospective cohort study with a historical control to evaluate the effect of RTX infusion followed by mycophenolate mofetil (MMF) as a maintenance therapy. Nine patients with SDNS who stopped their steroid treatment but were treated with MMF after RTX infusion were prospectively observed (group A). Seven patients with SDNS who discontinued steroid and immunosuppressive agents after RTX administration served as a control (group B). During the first year after the administration of RTX, six patients in group A and one patient in group B did not suffer a relapse (p\u2009<\u20090.05). The number of patients who relapsed during the 1 year preceding RTX treatment did not differ between the two groups [4.1 (A) vs. 5.7 (B)], but it was significantly lower in the MMF-treated group 1 year after the RTX treatment [0.4 (A) vs. 2.3 (B), p\u2009<\u20090.005]. The daily amount of prednisolone after the RTX treatment was lower in group A than in group B (0.11 vs. 0.46 mg/kg/day, respectively; p\u2009<\u20090.05). Three patients in group A and five patients in group B relapsed to SDNS and needed additional RTX treatment(s) within 1 year (odds ratio 5.0). Based on these results, we conclude that maintenance therapy with MMF after RTX is a good clinical option.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00467-011-1886-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097267", 
        "issn": [
          "0931-041X", 
          "1432-198X"
        ], 
        "name": "Pediatric Nephrology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Maintenance therapy with mycophenolate mofetil after rituximab in pediatric patients with steroid-dependent nephrotic syndrome", 
    "pagination": "1823-1828", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b89d3d66c11d142ea66089703cd90e732cc602c24f6fc71182b8f84add032f60"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21556716"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8708728"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00467-011-1886-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038755333"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00467-011-1886-x", 
      "https://app.dimensions.ai/details/publication/pub.1038755333"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000490.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00467-011-1886-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00467-011-1886-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00467-011-1886-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00467-011-1886-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00467-011-1886-x'


 

This table displays all metadata directly associated to this object as RDF triples.

271 TRIPLES      21 PREDICATES      68 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00467-011-1886-x schema:about N00b4549c4e8a43beb0607859c51c869c
2 N0f41621877dd433aaaecf6da99acb129
3 N24d7ffc0928b4d58bc97f53c98be596d
4 N343ede570f694ea3b01b3feabcaf8b44
5 N389738c5d6ab47989dffc5fa729bff9d
6 N3aa736e90a324c60b417a3806f1010e1
7 N3c3e9b64e33d421a958aecbfeb9a0f8d
8 N5af907a707704c8eb17afa54d18d2ece
9 N5fe0efd4891549e79019abf24fe9e72d
10 N6125d6d78051452c9f3c6264773ef38d
11 N645037a69c5f4cf790e3a9fa4717d6b3
12 N71ebaf7b919e46aebe17b79946f2378a
13 N794cdc04be25460db80685a626c8fe77
14 N825f308f2386408e8b1ddb4186133ad9
15 N94a7013e84ed409bb1da6e966e4cd1e1
16 Na163725f1610487d8ec65dace4227c57
17 Na3030d436b994e05aaed7fb3e4daf750
18 Nb5769b23e1604bc993a3aa1c5833a56f
19 Nd3d27a3144734d4ea7f9ac2e8829d84c
20 Nec030516f9ff4cda82a6dcf5d640d43c
21 Neccab0a278a5434d86af272f613e4b54
22 Nf190953706dd4b7ea4a6942b560a6267
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N8ad2168aba9541348fa70a6ae608c01d
26 schema:citation sg:pub.10.1007/s00467-004-1434-z
27 sg:pub.10.1007/s00467-005-2013-7
28 sg:pub.10.1007/s00467-006-0294-0
29 sg:pub.10.1007/s00467-008-0814-1
30 sg:pub.10.1007/s00467-008-0899-6
31 sg:pub.10.1007/s00467-008-1030-8
32 sg:pub.10.1007/s00467-009-1191-0
33 sg:pub.10.1007/s00467-009-1195-9
34 sg:pub.10.1007/s00467-009-1377-5
35 sg:pub.10.1007/s00467-010-1465-6
36 sg:pub.10.1046/j.1523-1755.2002.00303.x
37 https://doi.org/10.1002/ppul.20864
38 https://doi.org/10.1016/s0022-3476(81)80760-3
39 https://doi.org/10.1016/s0140-6736(81)92348-5
40 https://doi.org/10.1182/blood-2008-10-186999
41 https://doi.org/10.2215/cjn.00550206
42 https://doi.org/10.2215/cjn.05691108
43 schema:datePublished 2011-10
44 schema:datePublishedReg 2011-10-01
45 schema:description Rituximab (RTX) has a significant steroid-sparing effect in children with steroid-dependent nephrotic syndrome (SDNS). However, patients are likely to relapse with the recovery of CD20+ cells. We conducted a small prospective cohort study with a historical control to evaluate the effect of RTX infusion followed by mycophenolate mofetil (MMF) as a maintenance therapy. Nine patients with SDNS who stopped their steroid treatment but were treated with MMF after RTX infusion were prospectively observed (group A). Seven patients with SDNS who discontinued steroid and immunosuppressive agents after RTX administration served as a control (group B). During the first year after the administration of RTX, six patients in group A and one patient in group B did not suffer a relapse (p < 0.05). The number of patients who relapsed during the 1 year preceding RTX treatment did not differ between the two groups [4.1 (A) vs. 5.7 (B)], but it was significantly lower in the MMF-treated group 1 year after the RTX treatment [0.4 (A) vs. 2.3 (B), p < 0.005]. The daily amount of prednisolone after the RTX treatment was lower in group A than in group B (0.11 vs. 0.46 mg/kg/day, respectively; p < 0.05). Three patients in group A and five patients in group B relapsed to SDNS and needed additional RTX treatment(s) within 1 year (odds ratio 5.0). Based on these results, we conclude that maintenance therapy with MMF after RTX is a good clinical option.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N2a18a5fe019649248c4751ebd497d345
50 Nebd00963dcb54bffb281ded5094fc4dc
51 sg:journal.1097267
52 schema:name Maintenance therapy with mycophenolate mofetil after rituximab in pediatric patients with steroid-dependent nephrotic syndrome
53 schema:pagination 1823-1828
54 schema:productId N8f5d2694753549c49f367c5c9ca022f0
55 Na3cddffc6e314400a71805166dcad8c5
56 Na9bdd683b6e643faaf9943f5a5f67e7b
57 Nb0e1ce0179bc484bae44eb71e035fdfb
58 Nbe6de770258c41e4ba7a011f01c65769
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038755333
60 https://doi.org/10.1007/s00467-011-1886-x
61 schema:sdDatePublished 2019-04-10T23:19
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N07759e8f95db48b3a72ec18876ac5ca9
64 schema:url http://link.springer.com/10.1007/s00467-011-1886-x
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N00b4549c4e8a43beb0607859c51c869c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Pilot Projects
70 rdf:type schema:DefinedTerm
71 N07759e8f95db48b3a72ec18876ac5ca9 schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 N0f41621877dd433aaaecf6da99acb129 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Prednisolone
75 rdf:type schema:DefinedTerm
76 N24d7ffc0928b4d58bc97f53c98be596d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Anti-Inflammatory Agents
78 rdf:type schema:DefinedTerm
79 N2a18a5fe019649248c4751ebd497d345 schema:issueNumber 10
80 rdf:type schema:PublicationIssue
81 N343ede570f694ea3b01b3feabcaf8b44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Adolescent
83 rdf:type schema:DefinedTerm
84 N389738c5d6ab47989dffc5fa729bff9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Male
86 rdf:type schema:DefinedTerm
87 N3aa736e90a324c60b417a3806f1010e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Rituximab
89 rdf:type schema:DefinedTerm
90 N3c3e9b64e33d421a958aecbfeb9a0f8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Prospective Studies
92 rdf:type schema:DefinedTerm
93 N4cb2dbcb59a247aabe1b246f890db13c rdf:first sg:person.01316365041.17
94 rdf:rest Nae2276138d1241a39c39e427b1ef6ec4
95 N5af907a707704c8eb17afa54d18d2ece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Secondary Prevention
97 rdf:type schema:DefinedTerm
98 N5fe0efd4891549e79019abf24fe9e72d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Immunosuppressive Agents
100 rdf:type schema:DefinedTerm
101 N6125d6d78051452c9f3c6264773ef38d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Antibodies, Monoclonal, Murine-Derived
103 rdf:type schema:DefinedTerm
104 N645037a69c5f4cf790e3a9fa4717d6b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Treatment Outcome
106 rdf:type schema:DefinedTerm
107 N71ebaf7b919e46aebe17b79946f2378a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Mycophenolic Acid
109 rdf:type schema:DefinedTerm
110 N794cdc04be25460db80685a626c8fe77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Child
112 rdf:type schema:DefinedTerm
113 N825f308f2386408e8b1ddb4186133ad9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Young Adult
115 rdf:type schema:DefinedTerm
116 N842049f8a1ca4478a1aa46c0ea1a5a11 rdf:first sg:person.0622744202.64
117 rdf:rest N8bb51c0b402d452f9936f4b916d71b5a
118 N8ad2168aba9541348fa70a6ae608c01d rdf:first sg:person.012302533312.63
119 rdf:rest N4cb2dbcb59a247aabe1b246f890db13c
120 N8bb51c0b402d452f9936f4b916d71b5a rdf:first sg:person.015327457417.53
121 rdf:rest Ncecf26f830d74b6caf56667dc4381fb8
122 N8f5d2694753549c49f367c5c9ca022f0 schema:name readcube_id
123 schema:value b89d3d66c11d142ea66089703cd90e732cc602c24f6fc71182b8f84add032f60
124 rdf:type schema:PropertyValue
125 N94a7013e84ed409bb1da6e966e4cd1e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Steroids
127 rdf:type schema:DefinedTerm
128 N9542042f10754e88b095e1c610abf481 rdf:first sg:person.01060345462.48
129 rdf:rest N842049f8a1ca4478a1aa46c0ea1a5a11
130 N9ce99f18aaaf4e718961489f628f8f1d rdf:first sg:person.01360637141.54
131 rdf:rest rdf:nil
132 Na163725f1610487d8ec65dace4227c57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Antigens, CD20
134 rdf:type schema:DefinedTerm
135 Na3030d436b994e05aaed7fb3e4daf750 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Child, Preschool
137 rdf:type schema:DefinedTerm
138 Na3cddffc6e314400a71805166dcad8c5 schema:name dimensions_id
139 schema:value pub.1038755333
140 rdf:type schema:PropertyValue
141 Na9bdd683b6e643faaf9943f5a5f67e7b schema:name pubmed_id
142 schema:value 21556716
143 rdf:type schema:PropertyValue
144 Nae2276138d1241a39c39e427b1ef6ec4 rdf:first sg:person.01174574062.16
145 rdf:rest N9542042f10754e88b095e1c610abf481
146 Nb0e1ce0179bc484bae44eb71e035fdfb schema:name nlm_unique_id
147 schema:value 8708728
148 rdf:type schema:PropertyValue
149 Nb5769b23e1604bc993a3aa1c5833a56f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Nephrotic Syndrome
151 rdf:type schema:DefinedTerm
152 Nbe6de770258c41e4ba7a011f01c65769 schema:name doi
153 schema:value 10.1007/s00467-011-1886-x
154 rdf:type schema:PropertyValue
155 Ncecf26f830d74b6caf56667dc4381fb8 rdf:first sg:person.01267226363.98
156 rdf:rest N9ce99f18aaaf4e718961489f628f8f1d
157 Nd3d27a3144734d4ea7f9ac2e8829d84c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Nebd00963dcb54bffb281ded5094fc4dc schema:volumeNumber 26
161 rdf:type schema:PublicationVolume
162 Nec030516f9ff4cda82a6dcf5d640d43c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Kaplan-Meier Estimate
164 rdf:type schema:DefinedTerm
165 Neccab0a278a5434d86af272f613e4b54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Female
167 rdf:type schema:DefinedTerm
168 Nf190953706dd4b7ea4a6942b560a6267 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Survival Analysis
170 rdf:type schema:DefinedTerm
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
175 schema:name Clinical Sciences
176 rdf:type schema:DefinedTerm
177 sg:journal.1097267 schema:issn 0931-041X
178 1432-198X
179 schema:name Pediatric Nephrology
180 rdf:type schema:Periodical
181 sg:person.01060345462.48 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
182 schema:familyName Sato
183 schema:givenName Mai
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060345462.48
185 rdf:type schema:Person
186 sg:person.01174574062.16 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
187 schema:familyName Ogura
188 schema:givenName Masao
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174574062.16
190 rdf:type schema:Person
191 sg:person.012302533312.63 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
192 schema:familyName Ito
193 schema:givenName Shuichi
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012302533312.63
195 rdf:type schema:Person
196 sg:person.01267226363.98 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
197 schema:familyName Udagawa
198 schema:givenName Tomohiro
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267226363.98
200 rdf:type schema:Person
201 sg:person.01316365041.17 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
202 schema:familyName Kamei
203 schema:givenName Koichi
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316365041.17
205 rdf:type schema:Person
206 sg:person.01360637141.54 schema:affiliation https://www.grid.ac/institutes/grid.31432.37
207 schema:familyName Iijima
208 schema:givenName Kazumoto
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360637141.54
210 rdf:type schema:Person
211 sg:person.015327457417.53 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
212 schema:familyName Ishikawa
213 schema:givenName Tomoaki
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015327457417.53
215 rdf:type schema:Person
216 sg:person.0622744202.64 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
217 schema:familyName Fujimaru
218 schema:givenName Takuya
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622744202.64
220 rdf:type schema:Person
221 sg:pub.10.1007/s00467-004-1434-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1034927167
222 https://doi.org/10.1007/s00467-004-1434-z
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s00467-005-2013-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045340328
225 https://doi.org/10.1007/s00467-005-2013-7
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/s00467-006-0294-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001089825
228 https://doi.org/10.1007/s00467-006-0294-0
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/s00467-008-0814-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047664910
231 https://doi.org/10.1007/s00467-008-0814-1
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/s00467-008-0899-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019693863
234 https://doi.org/10.1007/s00467-008-0899-6
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/s00467-008-1030-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034882908
237 https://doi.org/10.1007/s00467-008-1030-8
238 rdf:type schema:CreativeWork
239 sg:pub.10.1007/s00467-009-1191-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052697168
240 https://doi.org/10.1007/s00467-009-1191-0
241 rdf:type schema:CreativeWork
242 sg:pub.10.1007/s00467-009-1195-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028250994
243 https://doi.org/10.1007/s00467-009-1195-9
244 rdf:type schema:CreativeWork
245 sg:pub.10.1007/s00467-009-1377-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022984402
246 https://doi.org/10.1007/s00467-009-1377-5
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s00467-010-1465-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013692046
249 https://doi.org/10.1007/s00467-010-1465-6
250 rdf:type schema:CreativeWork
251 sg:pub.10.1046/j.1523-1755.2002.00303.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002280019
252 https://doi.org/10.1046/j.1523-1755.2002.00303.x
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/ppul.20864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032788189
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0022-3476(81)80760-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022626465
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0140-6736(81)92348-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033459468
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1182/blood-2008-10-186999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023377809
261 rdf:type schema:CreativeWork
262 https://doi.org/10.2215/cjn.00550206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031234598
263 rdf:type schema:CreativeWork
264 https://doi.org/10.2215/cjn.05691108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031173083
265 rdf:type schema:CreativeWork
266 https://www.grid.ac/institutes/grid.31432.37 schema:alternateName Kobe University
267 schema:name Department of Pediatrics, School of Medicine, Kobe University, Kobe, Japan
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.63906.3a schema:alternateName National Center For Child Health and Development
270 schema:name Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, 157-8535, Setagaya-ku, Tokyo, Japan
271 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...