Posterior reversible encephalopathy syndrome in children with kidney diseases View Full Text


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Article Info

DATE

2011-05-11

AUTHORS

Kenji Ishikura, Yuko Hamasaki, Tomoyuki Sakai, Hiroshi Hataya, Robert H. Mak, Masataka Honda

ABSTRACT

Posterior reversible encephalopathy syndrome (PRES) was originally used to describe a reversible, predominantly posterior leukoencephalopathy in patients who had renal insufficiency, hypertension, or who received immunosuppressive therapy. Since PRES is prevalent in children with kidney diseases, awareness and understanding of it is important for practicing pediatric nephrologists. A comprehensive approach to the diagnosis of PRES includes thorough determination of predisposing factors, clinical symptoms, and mandatory appropriate imaging. Unfortunately, the pathophysiology of PRES is still obscure and specificity of radiological examination has not yet been established. Two major predisposing factors, namely hypertension and calcineurin inhibitors, are well recognized. In addition, nephrotic syndrome is a common underlying condition for development of PRES. Frequent symptoms include altered consciousness (coma, stupor, lethargy, confusion), seizure, headache, and visual disturbance. Most of these symptoms usually develop abruptly and resolve within a few weeks after proper management. Cranial magnetic resonance (MR) imaging is the first-line modality of imaging studies for detecting PRES. Diffusion-weighted imaging with quantification of apparent diffusion coefficient (ADC) values by ADC mapping may provide more accurate and specific images in the future. More... »

PAGES

375-384

References to SciGraph publications

  • 2005-06. Neuropathological correlates of reversible posterior leukoencephalopathy in NEUROCRITICAL CARE
  • 2003-12-16. Reversible posterior leukoencephalopathy in a patient with Wegener granulomatosis in PEDIATRIC NEPHROLOGY
  • 2001-07. Reversible encephalopathy associated with tacrolimus in pediatric renal transplants in PEDIATRIC NEPHROLOGY
  • 2004-08-19. Hypertension induced reversible posterior leukoencephalopathy syndrome: a report of two cases in EUROPEAN JOURNAL OF PEDIATRICS
  • 2010-02-01. Acute post-streptococcal glomerulonephritis in children of French Polynesia: a 3-year retrospective study in PEDIATRIC NEPHROLOGY
  • 2005-04-01. Tacrolimus-Related Encephalopathy following Allogeneic Stem Cell Transplantation in Children in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2007-06-07. Molecular mechanism of edema formation in nephrotic syndrome: therapeutic implications in PEDIATRIC NEPHROLOGY
  • 2003-09-19. Is reversible posterior leukoencephalopathy with severe hypertension completely reversible in all patients? in PEDIATRIC NEPHROLOGY
  • 2001-07. Posterior leukoencephalopathy syndrome in poststreptococcal acute glomerulonephritis in PEDIATRIC NEPHROLOGY
  • 2005-02-17. The use of cyclosporine in a boy with a prior episode of posterior encephalopathy in PEDIATRIC NEPHROLOGY
  • 2004-09-24. Reversible encephalopathy syndrome: report of 12 cases with follow-up in NEURORADIOLOGY
  • 2006-11-21. Posterior reversible encephalopathy syndrome in intensive care medicine in INTENSIVE CARE MEDICINE
  • 1999-05. Cyclosporine neurotoxicity: a review in JOURNAL OF NEUROLOGY
  • 2007-07-26. Posterior reversible encephalopathy in a child with Langerhans cell histiocytosis following allogeneic PBSCT treatment with cyclosporine in EUROPEAN JOURNAL OF PEDIATRICS
  • 2010-12-10. Children with posterior reversible encephalopathy syndrome associated with atypical diffusion-weighted imaging and apparent diffusion coefficient in CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00467-011-1873-2

    DOI

    http://dx.doi.org/10.1007/s00467-011-1873-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013448710

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21556718


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