Single infusion of rituximab for persistent steroid-dependent minimal-change nephrotic syndrome after long-term cyclosporine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03

AUTHORS

Shuichiro Fujinaga, Daishi Hirano, Naoto Nishizaki, Koichi Kamei, Shuichi Ito, Yoshiyuki Ohtomo, Toshiaki Shimizu, Kazunari Kaneko

ABSTRACT

Rituximab (RTX) has been successfully used as a rescue therapy in children with steroid-dependent nephrotic syndrome (SDNS). However, little is known regarding maintenance therapy after a successful response to RTX in such patients. The efficacy and safety of a single RTX infusion (375 mg/m(2)) were assessed in ten patients who had persistent SDNS associated with minimal-change disease (MCD) despite the long-term use of cyclosporine (CsA). The mean follow-up after RTX infusion was 17 months. Applying RTX resulted in a significant reduction in the mean prednisolone (PSL) dose from 0.39 +/-0.18 to 0.15 +/- 0.14 mg/kg per day. The mean 12-month relapse rates significantly decreased from 4.1 +/- 1.7 to 0.6 +/- 0.6. All but one patient who had continued CsA as maintenance therapy after a single RTX infusion were able to withdraw from PSL without any relapses during the study period, whereas the remaining five patients who discontinued CsA experienced relapses after CD19 cells re-emerged, leading to the reintroduction of CsA or an additional RTX infusion. Infusion reactions occurred in five of ten patients. These data indicate that a single RTX infusion may improve response to CsA in patients with persistent SDNS due to the phenomenon of secondary resistance to CsA. More... »

PAGES

539-544

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-009-1377-5

DOI

http://dx.doi.org/10.1007/s00467-009-1377-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022984402

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20049616


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Murine-Derived", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclosporine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunosuppressive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephrosis, Lipoid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prednisolone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rituximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Steroids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Saitama Children's Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416697.b", 
          "name": [
            "Division of Nephrology, Saitama Children\u2032s Medical Center, 2100 Magome, Iwatsuki-ward, 339 8551, Saitama-city, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujinaga", 
        "givenName": "Shuichiro", 
        "id": "sg:person.01365552065.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365552065.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Saitama Children's Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416697.b", 
          "name": [
            "Division of Nephrology, Saitama Children\u2032s Medical Center, 2100 Magome, Iwatsuki-ward, 339 8551, Saitama-city, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirano", 
        "givenName": "Daishi", 
        "id": "sg:person.0710261165.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710261165.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Saitama Children's Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416697.b", 
          "name": [
            "Division of Nephrology, Saitama Children\u2032s Medical Center, 2100 Magome, Iwatsuki-ward, 339 8551, Saitama-city, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishizaki", 
        "givenName": "Naoto", 
        "id": "sg:person.0756374365.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756374365.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology, National Center for Child Health and Development, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamei", 
        "givenName": "Koichi", 
        "id": "sg:person.01316365041.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316365041.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Child Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.63906.3a", 
          "name": [
            "Division of Nephrology, National Center for Child Health and Development, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Shuichi", 
        "id": "sg:person.012302533312.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012302533312.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, Juntendo Nerima Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtomo", 
        "givenName": "Yoshiyuki", 
        "id": "sg:person.01037465220.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037465220.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimizu", 
        "givenName": "Toshiaki", 
        "id": "sg:person.010504007022.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010504007022.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Pediatrics, Kansai Medical University, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaneko", 
        "givenName": "Kazunari", 
        "id": "sg:person.011754227562.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011754227562.93"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00467-006-0294-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001089825", 
          "https://doi.org/10.1007/s00467-006-0294-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-006-0294-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001089825", 
          "https://doi.org/10.1007/s00467-006-0294-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-006-0427-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005006895", 
          "https://doi.org/10.1007/s00467-006-0427-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-006-0427-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005006895", 
          "https://doi.org/10.1007/s00467-006-0427-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc063706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006041047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2007.02.270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012388686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(74)91880-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017067259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(74)91880-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017067259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-007-0596-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020427819", 
          "https://doi.org/10.1007/s00467-007-0596-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-007-0596-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020427819", 
          "https://doi.org/10.1007/s00467-007-0596-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-005-1932-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027983866", 
          "https://doi.org/10.1007/s00467-005-1932-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-005-1932-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027983866", 
          "https://doi.org/10.1007/s00467-005-1932-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-005-1932-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027983866", 
          "https://doi.org/10.1007/s00467-005-1932-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1226-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029092830", 
          "https://doi.org/10.1007/s00467-009-1226-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1226-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029092830", 
          "https://doi.org/10.1007/s00467-009-1226-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1226-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029092830", 
          "https://doi.org/10.1007/s00467-009-1226-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2006.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032128819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-1030-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034882908", 
          "https://doi.org/10.1007/s00467-008-1030-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-1030-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034882908", 
          "https://doi.org/10.1007/s00467-008-1030-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-004-1434-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034927167", 
          "https://doi.org/10.1007/s00467-004-1434-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/18.2.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038231963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-006-0228-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042686378", 
          "https://doi.org/10.1007/s00467-006-0228-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-006-0228-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042686378", 
          "https://doi.org/10.1007/s00467-006-0228-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1442-200x.2007.02487.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043005837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1620/tjem.214.27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045600759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mop.0b013e3282f4307a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045789251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mop.0b013e3282f4307a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045789251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-0814-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047664910", 
          "https://doi.org/10.1007/s00467-008-0814-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-008-0814-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047664910", 
          "https://doi.org/10.1007/s00467-008-0814-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/adc.2005.080960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051533809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1191-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052697168", 
          "https://doi.org/10.1007/s00467-009-1191-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1191-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052697168", 
          "https://doi.org/10.1007/s00467-009-1191-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1191-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052697168", 
          "https://doi.org/10.1007/s00467-009-1191-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5414/cnp60242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072832619"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-03", 
    "datePublishedReg": "2010-03-01", 
    "description": "Rituximab (RTX) has been successfully used as a rescue therapy in children with steroid-dependent nephrotic syndrome (SDNS). However, little is known regarding maintenance therapy after a successful response to RTX in such patients. The efficacy and safety of a single RTX infusion (375 mg/m(2)) were assessed in ten patients who had persistent SDNS associated with minimal-change disease (MCD) despite the long-term use of cyclosporine (CsA). The mean follow-up after RTX infusion was 17 months. Applying RTX resulted in a significant reduction in the mean prednisolone (PSL) dose from 0.39 +/-0.18 to 0.15 +/- 0.14 mg/kg per day. The mean 12-month relapse rates significantly decreased from 4.1 +/- 1.7 to 0.6 +/- 0.6. All but one patient who had continued CsA as maintenance therapy after a single RTX infusion were able to withdraw from PSL without any relapses during the study period, whereas the remaining five patients who discontinued CsA experienced relapses after CD19 cells re-emerged, leading to the reintroduction of CsA or an additional RTX infusion. Infusion reactions occurred in five of ten patients. These data indicate that a single RTX infusion may improve response to CsA in patients with persistent SDNS due to the phenomenon of secondary resistance to CsA.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00467-009-1377-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097267", 
        "issn": [
          "0931-041X", 
          "1432-198X"
        ], 
        "name": "Pediatric Nephrology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "name": "Single infusion of rituximab for persistent steroid-dependent minimal-change nephrotic syndrome after long-term cyclosporine", 
    "pagination": "539-544", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6d80d2f1fa4c877fdee0ccee044fc28f15a8a37dd241f261680638b0d6276775"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20049616"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8708728"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00467-009-1377-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022984402"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00467-009-1377-5", 
      "https://app.dimensions.ai/details/publication/pub.1022984402"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89793_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00467-009-1377-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00467-009-1377-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00467-009-1377-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00467-009-1377-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00467-009-1377-5'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      71 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00467-009-1377-5 schema:about N05dde05288a94f6d83944ad5fcbe793a
2 N06596cf9d98a4e7e8b2fc78c397cdfd2
3 N07e8512e95234f68a659653d96fed5ab
4 N1464e2486cc147af9658103f5e71f70f
5 N2c4e144d39a8414abd0fe6715721aaf8
6 N30b3c4241118450bb953820e381ec54e
7 N420248e889eb4fcb94cb2d576fbadd7f
8 N439dc9c6750e4c1da8e135fc5c2f776d
9 N479271c969664993a3f38003b68b972e
10 N5ea607f3ffb14650a7a719f11465a4b3
11 N6de3d79c43714a84b319ebb160c9418a
12 N7610d9442bc5409c93275a086b7e4dbd
13 N8104f039d07741f7bd8c31969d3e3a6c
14 N8b3398db492a4158892ec09287e81468
15 N9e15fb8fd0c84043850974442e54297f
16 Na5df68b1f2c248c2b8fd93614ca8df32
17 Nb9e535d8279e4aaca13f0ef7dbbc2d6e
18 Nc4310eaef38d4332a72827cb0c36a45a
19 Nd1471db4a2e6492eabb02cd7b2bf464e
20 Ndd7eecd046e04452bd872423c7b6398a
21 Ne05c6e7cce16430f8bef7d9f45e87c01
22 Ne654ee3a2b854ef494b9f2be8d79c64b
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author Ncf9b127c52cb433e8272f9eabfdf60ca
26 schema:citation sg:pub.10.1007/s00467-004-1434-z
27 sg:pub.10.1007/s00467-005-1932-7
28 sg:pub.10.1007/s00467-006-0228-x
29 sg:pub.10.1007/s00467-006-0294-0
30 sg:pub.10.1007/s00467-006-0427-5
31 sg:pub.10.1007/s00467-007-0596-x
32 sg:pub.10.1007/s00467-008-0814-1
33 sg:pub.10.1007/s00467-008-1030-8
34 sg:pub.10.1007/s00467-009-1191-0
35 sg:pub.10.1007/s00467-009-1226-6
36 https://doi.org/10.1016/s0140-6736(74)91880-7
37 https://doi.org/10.1053/j.ajkd.2006.10.015
38 https://doi.org/10.1053/j.ajkd.2007.02.270
39 https://doi.org/10.1056/nejmc063706
40 https://doi.org/10.1093/ndt/18.2.245
41 https://doi.org/10.1097/mop.0b013e3282f4307a
42 https://doi.org/10.1111/j.1442-200x.2007.02487.x
43 https://doi.org/10.1136/adc.2005.080960
44 https://doi.org/10.1620/tjem.214.27
45 https://doi.org/10.5414/cnp60242
46 schema:datePublished 2010-03
47 schema:datePublishedReg 2010-03-01
48 schema:description Rituximab (RTX) has been successfully used as a rescue therapy in children with steroid-dependent nephrotic syndrome (SDNS). However, little is known regarding maintenance therapy after a successful response to RTX in such patients. The efficacy and safety of a single RTX infusion (375 mg/m(2)) were assessed in ten patients who had persistent SDNS associated with minimal-change disease (MCD) despite the long-term use of cyclosporine (CsA). The mean follow-up after RTX infusion was 17 months. Applying RTX resulted in a significant reduction in the mean prednisolone (PSL) dose from 0.39 +/-0.18 to 0.15 +/- 0.14 mg/kg per day. The mean 12-month relapse rates significantly decreased from 4.1 +/- 1.7 to 0.6 +/- 0.6. All but one patient who had continued CsA as maintenance therapy after a single RTX infusion were able to withdraw from PSL without any relapses during the study period, whereas the remaining five patients who discontinued CsA experienced relapses after CD19 cells re-emerged, leading to the reintroduction of CsA or an additional RTX infusion. Infusion reactions occurred in five of ten patients. These data indicate that a single RTX infusion may improve response to CsA in patients with persistent SDNS due to the phenomenon of secondary resistance to CsA.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N6177d8710aed4bf597bbf304e6aab79b
53 Nfd0f5fa3990f420499b84caded0508c2
54 sg:journal.1097267
55 schema:name Single infusion of rituximab for persistent steroid-dependent minimal-change nephrotic syndrome after long-term cyclosporine
56 schema:pagination 539-544
57 schema:productId N3bf7e32bfbcb497183c10a51028c34e5
58 N3e68616220c1489eae478e14641d54ac
59 Na45c44cc1b374c9fb478cb01d1b03628
60 Nea31499c7d9f483f9a81cc9bc48878e1
61 Nf8e41d96fcc7406aa7d174ec6ac9a533
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022984402
63 https://doi.org/10.1007/s00467-009-1377-5
64 schema:sdDatePublished 2019-04-11T09:53
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N84d3cee26cac45019ae9ba1917775193
67 schema:url http://link.springer.com/10.1007/s00467-009-1377-5
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N05dde05288a94f6d83944ad5fcbe793a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Female
73 rdf:type schema:DefinedTerm
74 N06596cf9d98a4e7e8b2fc78c397cdfd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Antibodies, Monoclonal
76 rdf:type schema:DefinedTerm
77 N07e8512e95234f68a659653d96fed5ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Anti-Inflammatory Agents
79 rdf:type schema:DefinedTerm
80 N1464e2486cc147af9658103f5e71f70f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Rituximab
82 rdf:type schema:DefinedTerm
83 N1a6bd52af91f42699717f252708f8412 rdf:first sg:person.012302533312.63
84 rdf:rest N8c5652c8643542699df5551e6d6b372c
85 N2c4e144d39a8414abd0fe6715721aaf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Child
87 rdf:type schema:DefinedTerm
88 N30b3c4241118450bb953820e381ec54e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Prednisolone
90 rdf:type schema:DefinedTerm
91 N3bf7e32bfbcb497183c10a51028c34e5 schema:name readcube_id
92 schema:value 6d80d2f1fa4c877fdee0ccee044fc28f15a8a37dd241f261680638b0d6276775
93 rdf:type schema:PropertyValue
94 N3e68616220c1489eae478e14641d54ac schema:name pubmed_id
95 schema:value 20049616
96 rdf:type schema:PropertyValue
97 N4061f2fd64b848b6bd0bdb4f47cc57bf rdf:first sg:person.0710261165.94
98 rdf:rest N60d3c29d8e7241d49ab30b82131f2806
99 N420248e889eb4fcb94cb2d576fbadd7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Antibodies, Monoclonal, Murine-Derived
101 rdf:type schema:DefinedTerm
102 N439dc9c6750e4c1da8e135fc5c2f776d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N479271c969664993a3f38003b68b972e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Lymphocytes
107 rdf:type schema:DefinedTerm
108 N5ea607f3ffb14650a7a719f11465a4b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Recurrence
110 rdf:type schema:DefinedTerm
111 N60d3c29d8e7241d49ab30b82131f2806 rdf:first sg:person.0756374365.58
112 rdf:rest N83b40c6acb5f41058b4468ad3ecb7b3f
113 N6177d8710aed4bf597bbf304e6aab79b schema:volumeNumber 25
114 rdf:type schema:PublicationVolume
115 N639bf5fb771748faa19eb2b32c1ba9ba schema:name Department of Pediatrics, Juntendo Nerima Hospital, Tokyo, Japan
116 rdf:type schema:Organization
117 N6de3d79c43714a84b319ebb160c9418a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adolescent
119 rdf:type schema:DefinedTerm
120 N7610d9442bc5409c93275a086b7e4dbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cyclosporine
122 rdf:type schema:DefinedTerm
123 N8104f039d07741f7bd8c31969d3e3a6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Follow-Up Studies
125 rdf:type schema:DefinedTerm
126 N83b40c6acb5f41058b4468ad3ecb7b3f rdf:first sg:person.01316365041.17
127 rdf:rest N1a6bd52af91f42699717f252708f8412
128 N84d3cee26cac45019ae9ba1917775193 schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N86a7a852bae8492bb7d036eec302ca32 rdf:first sg:person.010504007022.99
131 rdf:rest Ndbe8bbf1f3974db9b52a61da632f56dd
132 N8b3398db492a4158892ec09287e81468 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Drug Resistance
134 rdf:type schema:DefinedTerm
135 N8c5652c8643542699df5551e6d6b372c rdf:first sg:person.01037465220.39
136 rdf:rest N86a7a852bae8492bb7d036eec302ca32
137 N9e15fb8fd0c84043850974442e54297f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Immunosuppressive Agents
139 rdf:type schema:DefinedTerm
140 Na45c44cc1b374c9fb478cb01d1b03628 schema:name doi
141 schema:value 10.1007/s00467-009-1377-5
142 rdf:type schema:PropertyValue
143 Na5df68b1f2c248c2b8fd93614ca8df32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Steroids
145 rdf:type schema:DefinedTerm
146 Nb9e535d8279e4aaca13f0ef7dbbc2d6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Child, Preschool
148 rdf:type schema:DefinedTerm
149 Nc4310eaef38d4332a72827cb0c36a45a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Treatment Outcome
151 rdf:type schema:DefinedTerm
152 Ncf9b127c52cb433e8272f9eabfdf60ca rdf:first sg:person.01365552065.26
153 rdf:rest N4061f2fd64b848b6bd0bdb4f47cc57bf
154 Nd1471db4a2e6492eabb02cd7b2bf464e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Male
156 rdf:type schema:DefinedTerm
157 Ndbe8bbf1f3974db9b52a61da632f56dd rdf:first sg:person.011754227562.93
158 rdf:rest rdf:nil
159 Ndd7eecd046e04452bd872423c7b6398a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Antigens, CD19
161 rdf:type schema:DefinedTerm
162 Ne05c6e7cce16430f8bef7d9f45e87c01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Nephrosis, Lipoid
164 rdf:type schema:DefinedTerm
165 Ne654ee3a2b854ef494b9f2be8d79c64b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Infant
167 rdf:type schema:DefinedTerm
168 Nea31499c7d9f483f9a81cc9bc48878e1 schema:name nlm_unique_id
169 schema:value 8708728
170 rdf:type schema:PropertyValue
171 Nf8e41d96fcc7406aa7d174ec6ac9a533 schema:name dimensions_id
172 schema:value pub.1022984402
173 rdf:type schema:PropertyValue
174 Nfd0f5fa3990f420499b84caded0508c2 schema:issueNumber 3
175 rdf:type schema:PublicationIssue
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
180 schema:name Clinical Sciences
181 rdf:type schema:DefinedTerm
182 sg:journal.1097267 schema:issn 0931-041X
183 1432-198X
184 schema:name Pediatric Nephrology
185 rdf:type schema:Periodical
186 sg:person.01037465220.39 schema:affiliation N639bf5fb771748faa19eb2b32c1ba9ba
187 schema:familyName Ohtomo
188 schema:givenName Yoshiyuki
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037465220.39
190 rdf:type schema:Person
191 sg:person.010504007022.99 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
192 schema:familyName Shimizu
193 schema:givenName Toshiaki
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010504007022.99
195 rdf:type schema:Person
196 sg:person.011754227562.93 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
197 schema:familyName Kaneko
198 schema:givenName Kazunari
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011754227562.93
200 rdf:type schema:Person
201 sg:person.012302533312.63 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
202 schema:familyName Ito
203 schema:givenName Shuichi
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012302533312.63
205 rdf:type schema:Person
206 sg:person.01316365041.17 schema:affiliation https://www.grid.ac/institutes/grid.63906.3a
207 schema:familyName Kamei
208 schema:givenName Koichi
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316365041.17
210 rdf:type schema:Person
211 sg:person.01365552065.26 schema:affiliation https://www.grid.ac/institutes/grid.416697.b
212 schema:familyName Fujinaga
213 schema:givenName Shuichiro
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365552065.26
215 rdf:type schema:Person
216 sg:person.0710261165.94 schema:affiliation https://www.grid.ac/institutes/grid.416697.b
217 schema:familyName Hirano
218 schema:givenName Daishi
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710261165.94
220 rdf:type schema:Person
221 sg:person.0756374365.58 schema:affiliation https://www.grid.ac/institutes/grid.416697.b
222 schema:familyName Nishizaki
223 schema:givenName Naoto
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756374365.58
225 rdf:type schema:Person
226 sg:pub.10.1007/s00467-004-1434-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1034927167
227 https://doi.org/10.1007/s00467-004-1434-z
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/s00467-005-1932-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027983866
230 https://doi.org/10.1007/s00467-005-1932-7
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/s00467-006-0228-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042686378
233 https://doi.org/10.1007/s00467-006-0228-x
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s00467-006-0294-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001089825
236 https://doi.org/10.1007/s00467-006-0294-0
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/s00467-006-0427-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005006895
239 https://doi.org/10.1007/s00467-006-0427-5
240 rdf:type schema:CreativeWork
241 sg:pub.10.1007/s00467-007-0596-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020427819
242 https://doi.org/10.1007/s00467-007-0596-x
243 rdf:type schema:CreativeWork
244 sg:pub.10.1007/s00467-008-0814-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047664910
245 https://doi.org/10.1007/s00467-008-0814-1
246 rdf:type schema:CreativeWork
247 sg:pub.10.1007/s00467-008-1030-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034882908
248 https://doi.org/10.1007/s00467-008-1030-8
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s00467-009-1191-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052697168
251 https://doi.org/10.1007/s00467-009-1191-0
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s00467-009-1226-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029092830
254 https://doi.org/10.1007/s00467-009-1226-6
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0140-6736(74)91880-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017067259
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1053/j.ajkd.2006.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032128819
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1053/j.ajkd.2007.02.270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012388686
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1056/nejmc063706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006041047
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/ndt/18.2.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038231963
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1097/mop.0b013e3282f4307a schema:sameAs https://app.dimensions.ai/details/publication/pub.1045789251
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1442-200x.2007.02487.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043005837
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1136/adc.2005.080960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051533809
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1620/tjem.214.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045600759
273 rdf:type schema:CreativeWork
274 https://doi.org/10.5414/cnp60242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072832619
275 rdf:type schema:CreativeWork
276 https://www.grid.ac/institutes/grid.258269.2 schema:alternateName Juntendo University
277 schema:name Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.410783.9 schema:alternateName Kansai Medical University
280 schema:name Department of Pediatrics, Kansai Medical University, Osaka, Japan
281 rdf:type schema:Organization
282 https://www.grid.ac/institutes/grid.416697.b schema:alternateName Saitama Children's Medical Center
283 schema:name Division of Nephrology, Saitama Children′s Medical Center, 2100 Magome, Iwatsuki-ward, 339 8551, Saitama-city, Saitama, Japan
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.63906.3a schema:alternateName National Center For Child Health and Development
286 schema:name Division of Nephrology, National Center for Child Health and Development, Tokyo, Japan
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...