Insulin-like growth factor-I and bone: lessons from mice and men View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-07-01

AUTHORS

Masanobu Kawai, Clifford J. Rosen

ABSTRACT

Studies of humans and animals have illustrated a strong association between insulin-like growth factor (IGF)-I and skeletal acquisition. However, the precise molecular and cellular mechanisms underlying this effect still largely remain unknown. Recent advances in molecular and genetic techniques for in vivo studies provide excellent tools for us to explore how circulating and skeletal insulin-like growth factor-I (IGF-I) may affect not only peak bone mass but also bone loss. This review highlights recent findings that shed new light on the interaction of the IGF-I signaling pathway with other skeletal networks, and the role of IGF-I in the bone marrow milieu. More... »

PAGES

1277-1285

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-008-1040-6

DOI

http://dx.doi.org/10.1007/s00467-008-1040-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041108714

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19011906


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