Recurrence of proteinuria 10 years post-transplant in NPHS2-associated focal segmental glomerulosclerosis after conversion from cyclosporin A to sirolimus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05-24

AUTHORS

Britta Höcker, Tanja Knüppel, Rüdiger Waldherr, Franz Schaefer, Stefanie Weber, Burkhard Tönshoff

ABSTRACT

Mutations in the NPHS2 gene, which encodes podocin, are associated with steroid-resistant nephrotic syndrome in childhood. Renal histology frequently presents focal segmental glomerulosclerosis (FSGS). Post-transplant recurrence of proteinuria in patients affected by homozygous or compound heterozygous NPHS2 mutation is encountered rarely (1–2%) compared to 30% recurrence in nonhereditary FSGS. We report on a pediatric kidney transplant recipient with NPHS2-associated nephrotic syndrome and FSGS, who developed biopsy-proven recurrence of FSGS 10 years post-transplant in temporal association with conversion from cyclosporin A (CsA)- to sirolimus (SRL)-based immunosuppression, due to histological evidence of severe CsA-induced nephrotoxicity. Reswitch of the immunosuppressive regimen from SRL to CsA led to a noticeable decrease of proteinuria and to stabilization of graft function. We conclude that patients with hereditary FSGS are not entirely protected from post-transplant recurrence of proteinuria, even in the long term. The close temporal relationship of FSGS recurrence with CsA withdrawal and conversion to SRL suggests that caution should be exercised in the use of CsA-free immunosuppression also in patients with NPHS2-associated FSGS. More... »

PAGES

1476-1479

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-006-0148-9

DOI

http://dx.doi.org/10.1007/s00467-006-0148-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025832957

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16721582


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