Mycophenolate mofetil therapy in frequently relapsing steroid-dependent and steroid-resistant nephrotic syndrome of childhood: current status and future directions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-10

AUTHORS

Asha Moudgil, Arvind Bagga, Stanley C. Jordan

ABSTRACT

Clinicians are often faced with therapeutic dilemmas and challenges while treating children with frequently relapsing steroid-dependent nephrotic syndrome (SDNS) and steroid-resistant nephrotic syndrome (SRNS). In the past, children with SDNS have been treated with long-term alternate day steroids cyclophosphamide, cyclosporine (CSA), chlorambucil, levamisole, and azathioprine. The essential aim of these therapies is to maintain remission while limiting exposure to steroids. These medications have variable efficacy and undesirable toxicity profiles. Recently, mycophenolate mofetil (MMF) has emerged as a new therapeutic option for the management of SDNS in a few uncontrolled clinical trials. Preliminary data are encouraging. MMF was found to be useful in maintaining remission and has a steroid-sparing effect. Clearly, more data are needed to further characterize the safety and efficacy of MMF, define adequate length of treatment, and optimize drug exposure and monitoring. The management of SRNS is primarily aimed at decreasing proteinuria and inducing remission, if possible. By doing so, one would aim to preserve renal function. CSA therapy is known to be useful in this regard but has undesirable side effects, the most concerning being nephrotoxicity. MMF in combination with steroids and angiotensin-converting enzyme-inhibitor drugs is known to have some efficacy in the management of SRNS. These preliminary data have prompted the National Institutes of Health to sponsor a multicentric controlled trial to compare the safety and efficacy of MMF with that of CSA in the treatment of steroid-resistant focal segmental glomerulosclerosis (FSGS). If MMF therapy is found to be efficacious, it would help obviate the need for CSA and its associated nephrotoxicity. Clearly, MMF has emerged as an important new therapeutic option for the treatment of childhood nephrotic syndrome and FSGS. Further data are required to assess those conditions most likely to respond. More... »

PAGES

1376-1381

References to SciGraph publications

  • 2005-04. Switch from cyclosporine A to mycophenolate mofetil in nephrotic children in PEDIATRIC NEPHROLOGY
  • 1990-07. Treatment of steroid-resistant focal segmental glomerulosclerosis with pulse methylprednisolone and alkylating agents in PEDIATRIC NEPHROLOGY
  • 1992-01. Comparison of cyclosporin and chlorambucil in the treatment of steroid-dependent idiopathic nephrotic syndrome: a multicentre randomized controlled trial in PEDIATRIC NEPHROLOGY
  • 2003-07. Cyclophosphamide in steroid-sensitive nephrotic syndrome: outcome and outlook in PEDIATRIC NEPHROLOGY
  • 1991-07. Racial differences in the incidence and renal outcome of idiopathic focal segmental glomerulosclerosis in children in PEDIATRIC NEPHROLOGY
  • 2004-01. Frequently relapsing nephrotic syndrome: treatment with mycophenolate mofetil in PEDIATRIC NEPHROLOGY
  • 2001-05. Immunosuppressive agents in childhood nephrotic syndrome: A meta-analysis of randomized controlled trials in KIDNEY INTERNATIONAL
  • 1999-12. A randomized trial of cyclosporine in patients with steroid-resistant focal segmental glomerulosclerosis in KIDNEY INTERNATIONAL
  • 1999-08. Disseminated autoimmune disease during levamisole treatment of nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2000-07. Efficacy of long-term azathioprine for relapsing nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2003-08. Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 1998-11. Age and ethnicity affect the risk and outcome of focal segmental glomerulosclerosis in PEDIATRIC NEPHROLOGY
  • 1992-11. Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2002-05. Risk factors for cyclosporine-induced tubulointerstitial lesions in children with minimal change nephrotic syndrome in KIDNEY INTERNATIONAL
  • 1993-04. Long versus standard prednisone therapy for initial treatment of idiopathic nephrotic syndrome in children in EUROPEAN JOURNAL OF PEDIATRICS
  • 1994-02. Intravenous pulse cyclophosphamide — a new regime for steroid-resistant minimal change nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2001-11. Treatment of focal glomerulosclerosis with pulse steroids and oral cyclophosphamide in PEDIATRIC NEPHROLOGY
  • 2003-08. Novel therapy of focal glomerulosclerosis with mycophenolate and angiotensin blockade in PEDIATRIC NEPHROLOGY
  • 2002-09. Glucocorticoids interfere with mycophenolate mofetil bioavailability in kidney transplantation in KIDNEY INTERNATIONAL
  • 1997-07. Levamisole therapy in corticosteroid-dependent nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 2000-09. Enalapril and prednisone in children with nephrotic-range proteinuria in PEDIATRIC NEPHROLOGY
  • 2002-03. Mycophenolate mofetil treatment for primary glomerular diseases in KIDNEY INTERNATIONAL
  • 2003-04. Intravenous cyclophosphamide in steroid-resistant nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 1997-07. Intensive pulse therapies for focal glomerulosclerosis in South African children in PEDIATRIC NEPHROLOGY
  • 2000-02. Remission of relapsing childhood nephrotic syndrome with mycophenolate mofetil in PEDIATRIC NEPHROLOGY
  • 1999-02. Two-year cyclosporin treatment in children with steroid-dependent nephrotic syndrome in PEDIATRIC NEPHROLOGY
  • 1999-03. Pulse cyclophosphamide for steroid-resistant focal segmental glomerulosclerosis in PEDIATRIC NEPHROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00467-005-1964-z

    DOI

    http://dx.doi.org/10.1007/s00467-005-1964-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044731039

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15977023


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