A case of post-transplant hyperparathyroidism treated with ethanol injection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04

AUTHORS

T. Ohta, Takashi Sakano, Shohei Fuchinoue, Tetsuro Tsuji, Kazunari Tanabe, Motoshi Hattori, Hiroyuki Nagafuchi, Hiroshi Shiraga, Hirotaka Kihara, Yoshihisa Kinoshita, Katsumi Ito

ABSTRACT

A 15-year-old boy with chronic renal failure secondary to Alport’s syndrome underwent living-related renal transplantation from his 48-year-old father. His primary immunosuppressive regimen was composed of tacrolimus, mizolibine, and methylprednisolone. The postoperative course was satisfactory with one episode of mild acute rejection, treated successfully with methylprednisolone pulse therapy. Two months later, hypercalcemia (11.8–13.2 mg/dl) and hypophosphatemia (2.5–3.0 mg/dl) were noted without any bone symptoms. The serum intact-parathyroid hormone (PTH) and serum alkaline phosphatase levels were 240 pg/ml and 2483 IU/l, respectively. Ultrasound studies revealed enlargement of the two parathyroid glands. Under the diagnosis of ter-tiary hyperparathyroidism, he underwent percutaneous ethanol injection (PEIT) into the left parathyroid gland. Although levels of serum calcium and phosphorus returned to normal ranges and the intact PTH level decreased to 95 pg/ml with the three injections, another injection was needed to normalize recurrent hypercalcemia 2 months later. The patient experienced only transient mild dysphonia and local pain after PEIT. Although PEIT is believed less effective than parathyroidectomy, it has some advantages such as applicability to high-risk patients, repeatability of treatment, low incidence and severity of side effects. More... »

PAGES

236-238

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00467-001-0812-z

DOI

http://dx.doi.org/10.1007/s00467-001-0812-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049044066

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11956872


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