Long-term results of laparoscopic liver resection for the primary treatment of hepatocellular carcinoma: role of the surgeon in anatomical resection View Full Text


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Article Info

DATE

2018-04-24

AUTHORS

Woo-Hyoung Kang, Ki-Hun Kim, Dong-Hwan Jung, Gil-Chun Park, Seok-Hwan Kim, Hwui-Dong Cho, Sung-Gyu Lee

ABSTRACT

BackgroundLiver resection is a potentially curative therapy for hepatocellular carcinoma (HCC). LLR is a newly developed and safe technique associated with shorter hospital stay, less pain, better cosmetic outcomes, and similar complication rates as open surgery; however, data on its long-term outcomes remain scarce.MethodsWe retrospectively examined the clinical and follow-up data of 234 patients who underwent LLR (performed by a single surgeon in all cases) for the primary treatment of HCC between July 2007 and December 2015 at Asan Medical Center.ResultsThe mean patient age was 55.63 (range 31–76) years; 167 were men. The median follow-up duration was 38 (range 6–116) months. A total of 227 patients (97.0%) had Child–Turcotte–Pugh grade A disease. Of them, 167 (71.4%) underwent anatomical resections and 63 (28.6%) underwent non-anatomical partial hepatectomies. Overall survival rates were 98.3, 91.7, and 87.1%, and recurrence-free survival rates were 82.1, 67.5, and 55.3% at 1, 3, and 5 years, respectively. In Cox regression analysis, anatomical resection was a risk factor for recurrence (univariate analysis: hazard ratio [HR] 0.49; 95% confidence interval [CI] 0.31–0.75; p = 0.001; multivariate analysis: HR 0.59; 95% CI 0.38–0.94; p = 0.025).ConclusionsLLR is an acceptable primary treatment for patients with HCC with good hepatic function and with an appropriate anatomical structure, and is associated with improved prognosis. LLR can achieve lower recurrence rates through anatomical resection. More... »

PAGES

4481-4490

References to SciGraph publications

  • 2000-06. Laparoscopic hepatectomy: new approach for hepatocellular carcinoma in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2009-03-12. Laparoscopic liver resection facilitates salvage liver transplantation for hepatocellular carcinoma in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2011-08-13. Long-Term Results of Laparoscopic Hepatectomy Versus Open Hepatectomy for Hepatocellular Carcinoma: A Case-Matched Analysis in WORLD JOURNAL OF SURGERY
  • 2016-12-07. Pure laparoscopic right anterior sectionectomy for hepatocellular carcinoma with great vascular exposure in SURGICAL ENDOSCOPY
  • 2014-12-09. Oncological and surgical results of laparoscopic versus open liver resection for HCC less than 5 cm: case-matched analysis in SURGICAL ENDOSCOPY
  • 2012-12-27. Totally laparoscopic hepatectomy exposing the major vessels in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2010-02-09. Comparison of the outcomes between anatomical resection and limited resection for single hepatocellular carcinomas no larger than 5 cm in diameter: a single-center study in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2015-07-21. Laparoscopic versus open major hepatectomy for hepatocellular carcinoma: a matched pair analysis in SURGICAL ENDOSCOPY
  • 2015-05-09. The Impact of Tumor Size on Long-Term Survival Outcomes After Resection of Solitary Hepatocellular Carcinoma: Single-Institution Experience with 2558 Patients in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2016-09-12. Pure laparoscopic right hepatectomy for giant hemangioma using anterior approach in SURGICAL ENDOSCOPY
  • 2014-11-06. Analysis of Recurrence Patterns After Anatomical or Non-anatomical Resection for Hepatocellular Carcinoma in ANNALS OF SURGICAL ONCOLOGY
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    http://scigraph.springernature.com/pub.10.1007/s00464-018-6194-0

    DOI

    http://dx.doi.org/10.1007/s00464-018-6194-0

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    https://www.ncbi.nlm.nih.gov/pubmed/29691651


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    33 schema:datePublishedReg 2018-04-24
    34 schema:description BackgroundLiver resection is a potentially curative therapy for hepatocellular carcinoma (HCC). LLR is a newly developed and safe technique associated with shorter hospital stay, less pain, better cosmetic outcomes, and similar complication rates as open surgery; however, data on its long-term outcomes remain scarce.MethodsWe retrospectively examined the clinical and follow-up data of 234 patients who underwent LLR (performed by a single surgeon in all cases) for the primary treatment of HCC between July 2007 and December 2015 at Asan Medical Center.ResultsThe mean patient age was 55.63 (range 31–76) years; 167 were men. The median follow-up duration was 38 (range 6–116) months. A total of 227 patients (97.0%) had Child–Turcotte–Pugh grade A disease. Of them, 167 (71.4%) underwent anatomical resections and 63 (28.6%) underwent non-anatomical partial hepatectomies. Overall survival rates were 98.3, 91.7, and 87.1%, and recurrence-free survival rates were 82.1, 67.5, and 55.3% at 1, 3, and 5 years, respectively. In Cox regression analysis, anatomical resection was a risk factor for recurrence (univariate analysis: hazard ratio [HR] 0.49; 95% confidence interval [CI] 0.31–0.75; p = 0.001; multivariate analysis: HR 0.59; 95% CI 0.38–0.94; p = 0.025).ConclusionsLLR is an acceptable primary treatment for patients with HCC with good hepatic function and with an appropriate anatomical structure, and is associated with improved prognosis. LLR can achieve lower recurrence rates through anatomical resection.
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    41 schema:keywords Asan Medical Center
    42 BackgroundLiver resection
    43 Child-Turcotte
    44 ConclusionsLLR
    45 Cox regression analysis
    46 LLR
    47 Medical Center
    48 MethodsWe
    49 Pugh grade
    50 acceptable primary treatment
    51 age
    52 analysis
    53 anatomical resection
    54 anatomical structures
    55 appropriate anatomical structure
    56 carcinoma
    57 center
    58 complication rate
    59 cosmetic outcome
    60 curative therapy
    61 data
    62 disease
    63 duration
    64 factors
    65 follow
    66 function
    67 good cosmetic outcome
    68 good hepatic function
    69 grade
    70 hepatectomy
    71 hepatic function
    72 hepatocellular carcinoma
    73 hospital stay
    74 improved prognosis
    75 laparoscopic liver resection
    76 less pain
    77 liver resection
    78 long-term outcomes
    79 long-term results
    80 low recurrence rate
    81 median follow
    82 men
    83 months
    84 non-anatomical partial hepatectomies
    85 open surgery
    86 outcomes
    87 overall survival rate
    88 pain
    89 partial hepatectomy
    90 patient age
    91 patients
    92 primary treatment
    93 prognosis
    94 rate
    95 recurrence
    96 recurrence rate
    97 recurrence-free survival rates
    98 regression analysis
    99 resection
    100 results
    101 risk factors
    102 role
    103 safe technique
    104 shorter hospital stay
    105 similar complication rates
    106 stay
    107 structure
    108 surgeons
    109 surgery
    110 survival rate
    111 technique
    112 therapy
    113 total
    114 treatment
    115 years
    116 schema:name Long-term results of laparoscopic liver resection for the primary treatment of hepatocellular carcinoma: role of the surgeon in anatomical resection
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