Impact of surgical margins on overall and recurrence-free survival in parenchymal-sparing laparoscopic liver resections of colorectal metastases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09

AUTHORS

Roberto Montalti, Federico Tomassini, Stéphanie Laurent, Peter Smeets, Marc De Man, Karen Geboes, Louis J. Libbrecht, Roberto I. Troisi

ABSTRACT

BACKGROUND: The relationship between the width of surgical margins and local and distant recurrence of colorectal liver metastases (CRLM) remain controversial. We analyzed the impact of surgical margins in laparoscopic liver resections (LLR) for CRLM, using the parenchymal-sparing approach on overall (OS) and recurrence-free survival (RFS). METHODS: From January 2005 to October 2012, 114 first LLR for CRLM were performed and retrospectively analyzed. The ultrasonic aspirator was used for parenchyma division. R1 margins were defined when the tissue width was <1 mm. RESULTS: After a mean follow-up of 30.9 ± 1.71 months, OS was 97.1-73.9-58.9% and the RFS 64.2-35.2-31% at 1-3-5 years, respectively. The major resection rate was 7%. The median margin width was 3 (0-40) mm, and R1 resection was recorded in 14 (12.3%) cases. Twenty-two patients (33.3%) with hepatic recurrence underwent a repeat hepatectomy. R1 margins were significantly related to lower RFS survival (p = 0.038) but did not affect OS. Multivariate analysis showed that lesions located in postero-superior segments (HR = 2.4, 95% CI 1.24-4.61, p = 0.009) as well as blood loss (HR = 3.2, 95% CI 1.23-7.99, p = 0.012) were independent risk factors for tumor recurrence. The carcinoembryonic antigen level >10 mcg/L affected OS (HR = 4.2 95% CI 2.02-16.9, p = 0.001), and the resection of more than two tumors was significantly associated with R1 margins (HR = 9.32, 95% CI 1.14-32.5, p = 0.037). DISCUSSION: Laparoscopic parenchymal-sparing surgery of CRLM does not compromise the oncological outcome, allowing a higher percentage of repeat hepatectomy. R1 margins are a risk factor for tumor recurrence but not for overall survival. The presence of multiple lesions is the only independent risk factor of R1 margins and also the major disadvantage of this technique. More... »

PAGES

2736-2747

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00464-014-3999-3

DOI

http://dx.doi.org/10.1007/s00464-014-3999-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005741749

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25427420


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laparoscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Sparing Treatments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of General & Hepato-Biliary Surgery, Liver Transplantation Service, Ghent University Hospital and Medical School, De Pintelaan 185, 2K12 IC, 9000, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montalti", 
        "givenName": "Roberto", 
        "id": "sg:person.0703074332.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703074332.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of General & Hepato-Biliary Surgery, Liver Transplantation Service, Ghent University Hospital and Medical School, De Pintelaan 185, 2K12 IC, 9000, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomassini", 
        "givenName": "Federico", 
        "id": "sg:person.01351662764.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351662764.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laurent", 
        "givenName": "St\u00e9phanie", 
        "id": "sg:person.01232015026.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232015026.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smeets", 
        "givenName": "Peter", 
        "id": "sg:person.01107613563.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107613563.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Man", 
        "givenName": "Marc", 
        "id": "sg:person.015044246514.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015044246514.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geboes", 
        "givenName": "Karen", 
        "id": "sg:person.015506075672.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015506075672.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Libbrecht", 
        "givenName": "Louis J.", 
        "id": "sg:person.0722345435.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722345435.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of General & Hepato-Biliary Surgery, Liver Transplantation Service, Ghent University Hospital and Medical School, De Pintelaan 185, 2K12 IC, 9000, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Troisi", 
        "givenName": "Roberto I.", 
        "id": "sg:person.0606455504.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606455504.93"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1055-3207(02)00091-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000904609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2007.09.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002283817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800730917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002761672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00423-011-0872-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004510935", 
          "https://doi.org/10.1007/s00423-011-0872-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181b0c4df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004870718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181b0c4df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004870718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181b0c4df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004870718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2007.06.283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007152866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13651820410023987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007578253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31811ea962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010919743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31811ea962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010919743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9098(199810)69:2<88::aid-jso8>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014725274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hpb.12204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018132111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2356-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018888370", 
          "https://doi.org/10.1245/s10434-012-2356-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181557e47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021097579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181557e47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021097579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-3087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021709681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000145964.08365.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000145964.08365.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31824856f5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022177341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31824856f5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022177341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-011-2114-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022367853", 
          "https://doi.org/10.1245/s10434-011-2114-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-008-9629-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023017550", 
          "https://doi.org/10.1007/s00268-008-9629-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-008-9629-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023017550", 
          "https://doi.org/10.1007/s00268-008-9629-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1254::aid-cncr5>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025015403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-007-9703-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027017713", 
          "https://doi.org/10.1245/s10434-007-9703-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.5386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027975622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.0928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029306962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2168.1997.02743.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029679870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.7032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030884899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.7032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030884899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdm106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035305381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3182902b6e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035612056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3182902b6e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035612056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hpb.12083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038353515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.5762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039676320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0770-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041943234", 
          "https://doi.org/10.1245/s10434-009-0770-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0770-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041943234", 
          "https://doi.org/10.1245/s10434-009-0770-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1477-2574.2009.00092.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042398031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hpb.12077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044370370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e318223c609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046547313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e318223c609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046547313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050986757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2014.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051727177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e318283a4d1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051872923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e318283a4d1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051872923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1477-2574.2012.00547.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052438870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000160703.75808.7d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052575937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000160703.75808.7d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052575937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/145749691110000110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052686674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/145749691110000110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052686674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.8996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053493833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800840810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054296417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199804000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199804000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199804000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4251/wjgo.v5.i12.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072402004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076895666", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077179992", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31818a07f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077797244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079195975", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083070823", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-09", 
    "datePublishedReg": "2015-09-01", 
    "description": "BACKGROUND: The relationship between the width of surgical margins and local and distant recurrence of colorectal liver metastases (CRLM) remain controversial. We analyzed the impact of surgical margins in laparoscopic liver resections (LLR) for CRLM, using the parenchymal-sparing approach on overall (OS) and recurrence-free survival (RFS).\nMETHODS: From January 2005 to October 2012, 114 first LLR for CRLM were performed and retrospectively analyzed. The ultrasonic aspirator was used for parenchyma division. R1 margins were defined when the tissue width was <1 mm.\nRESULTS: After a mean follow-up of 30.9 \u00b1 1.71 months, OS was 97.1-73.9-58.9% and the RFS 64.2-35.2-31% at 1-3-5 years, respectively. The major resection rate was 7%. The median margin width was 3 (0-40) mm, and R1 resection was recorded in 14 (12.3%) cases. Twenty-two patients (33.3%) with hepatic recurrence underwent a repeat hepatectomy. R1 margins were significantly related to lower RFS survival (p = 0.038) but did not affect OS. Multivariate analysis showed that lesions located in postero-superior segments (HR = 2.4, 95% CI 1.24-4.61, p = 0.009) as well as blood loss (HR = 3.2, 95% CI 1.23-7.99, p = 0.012) were independent risk factors for tumor recurrence. The carcinoembryonic antigen level >10 mcg/L affected OS (HR = 4.2 95% CI 2.02-16.9, p = 0.001), and the resection of more than two tumors was significantly associated with R1 margins (HR = 9.32, 95% CI 1.14-32.5, p = 0.037).\nDISCUSSION: Laparoscopic parenchymal-sparing surgery of CRLM does not compromise the oncological outcome, allowing a higher percentage of repeat hepatectomy. R1 margins are a risk factor for tumor recurrence but not for overall survival. The presence of multiple lesions is the only independent risk factor of R1 margins and also the major disadvantage of this technique.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00464-014-3999-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1098220", 
        "issn": [
          "0930-2794", 
          "1432-2218"
        ], 
        "name": "Surgical Endoscopy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Impact of surgical margins on overall and recurrence-free survival in parenchymal-sparing laparoscopic liver resections of colorectal metastases", 
    "pagination": "2736-2747", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1b5b1b01c3b2f9a1a733e39c0dc0870eedd4d00fe97defe6f1516cb7bbb585ed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25427420"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806653"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00464-014-3999-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005741749"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00464-014-3999-3", 
      "https://app.dimensions.ai/details/publication/pub.1005741749"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000486.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00464-014-3999-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00464-014-3999-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00464-014-3999-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00464-014-3999-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00464-014-3999-3'


 

This table displays all metadata directly associated to this object as RDF triples.

353 TRIPLES      21 PREDICATES      96 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00464-014-3999-3 schema:about N09ea113d84ea4ac8b72c838bce9ab85f
2 N107042da0d2f402dac779a16352f228b
3 N11a3fc184f4f4f449a1858a6adaac47f
4 N358427ee60e1491c8b571401d09b9ade
5 N3f0f433bf9c5476281b5415f0a7cb2b1
6 N3f8e77d6196142d187860bb0858d6fc7
7 N4ad1fa1eb3bd42d2abeb4c018cca6b33
8 N6e2dc76d5c874cf0858c6e8f65e6cd0c
9 N783b9226d3024b9baec3fb49f9de8226
10 N851d3c6a23eb44f688f64805f030171a
11 N8e2a590997034017ace4e3f92efe3c05
12 Na8275702c900487598db57c6d6caddf2
13 Nb869b778d0964e628897d4dbe9869e78
14 Nbe31ac4a76cb4a2ca4a7099ceee72204
15 Ne01085174c814948802da22f7a6f32e8
16 Ne3ecd7c036674e5c8ced578084cb67ae
17 Neab6659f7793476db749c2f869fbd925
18 Nebc0f287794f404f8f0b8da225b392a5
19 Nf1aeb57e7abd427abdf2fbea0a3ff948
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author Ne1d9095572314935a6a9f4f9133e08a7
23 schema:citation sg:pub.10.1007/s00268-008-9629-2
24 sg:pub.10.1007/s00423-011-0872-x
25 sg:pub.10.1245/s10434-007-9703-2
26 sg:pub.10.1245/s10434-009-0770-4
27 sg:pub.10.1245/s10434-011-2114-4
28 sg:pub.10.1245/s10434-012-2356-9
29 https://app.dimensions.ai/details/publication/pub.1076895666
30 https://app.dimensions.ai/details/publication/pub.1077179992
31 https://app.dimensions.ai/details/publication/pub.1079195975
32 https://app.dimensions.ai/details/publication/pub.1083070823
33 https://doi.org/10.1002/(sici)1096-9098(199810)69:2<88::aid-jso8>3.0.co;2-x
34 https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1254::aid-cncr5>3.0.co;2-i
35 https://doi.org/10.1002/bjs.1800730917
36 https://doi.org/10.1002/bjs.1800840810
37 https://doi.org/10.1002/bjs.5386
38 https://doi.org/10.1002/bjs.5762
39 https://doi.org/10.1002/bjs.7032
40 https://doi.org/10.1002/bjs.8996
41 https://doi.org/10.1016/j.ejso.2014.01.005
42 https://doi.org/10.1016/j.jamcollsurg.2007.06.283
43 https://doi.org/10.1016/j.surg.2007.09.038
44 https://doi.org/10.1016/s1055-3207(02)00091-1
45 https://doi.org/10.1046/j.1365-2168.1997.02743.x
46 https://doi.org/10.1080/13651820410023987
47 https://doi.org/10.1093/annonc/mdm106
48 https://doi.org/10.1093/annonc/mds336
49 https://doi.org/10.1097/00000658-199804000-00019
50 https://doi.org/10.1097/00000658-199909000-00004
51 https://doi.org/10.1097/01.sla.0000133083.54934.ae
52 https://doi.org/10.1097/01.sla.0000145964.08365.01
53 https://doi.org/10.1097/01.sla.0000160703.75808.7d
54 https://doi.org/10.1097/sla.0b013e31811ea962
55 https://doi.org/10.1097/sla.0b013e3181557e47
56 https://doi.org/10.1097/sla.0b013e31818a07f1
57 https://doi.org/10.1097/sla.0b013e3181b0c4df
58 https://doi.org/10.1097/sla.0b013e318223c609
59 https://doi.org/10.1097/sla.0b013e31824856f5
60 https://doi.org/10.1097/sla.0b013e318283a4d1
61 https://doi.org/10.1097/sla.0b013e3182902b6e
62 https://doi.org/10.1111/hpb.12077
63 https://doi.org/10.1111/hpb.12083
64 https://doi.org/10.1111/hpb.12204
65 https://doi.org/10.1111/j.1477-2574.2009.00092.x
66 https://doi.org/10.1111/j.1477-2574.2012.00547.x
67 https://doi.org/10.1158/1078-0432.ccr-10-3087
68 https://doi.org/10.1177/145749691110000110
69 https://doi.org/10.1200/jco.2006.09.0928
70 https://doi.org/10.4251/wjgo.v5.i12.207
71 schema:datePublished 2015-09
72 schema:datePublishedReg 2015-09-01
73 schema:description BACKGROUND: The relationship between the width of surgical margins and local and distant recurrence of colorectal liver metastases (CRLM) remain controversial. We analyzed the impact of surgical margins in laparoscopic liver resections (LLR) for CRLM, using the parenchymal-sparing approach on overall (OS) and recurrence-free survival (RFS). METHODS: From January 2005 to October 2012, 114 first LLR for CRLM were performed and retrospectively analyzed. The ultrasonic aspirator was used for parenchyma division. R1 margins were defined when the tissue width was <1 mm. RESULTS: After a mean follow-up of 30.9 ± 1.71 months, OS was 97.1-73.9-58.9% and the RFS 64.2-35.2-31% at 1-3-5 years, respectively. The major resection rate was 7%. The median margin width was 3 (0-40) mm, and R1 resection was recorded in 14 (12.3%) cases. Twenty-two patients (33.3%) with hepatic recurrence underwent a repeat hepatectomy. R1 margins were significantly related to lower RFS survival (p = 0.038) but did not affect OS. Multivariate analysis showed that lesions located in postero-superior segments (HR = 2.4, 95% CI 1.24-4.61, p = 0.009) as well as blood loss (HR = 3.2, 95% CI 1.23-7.99, p = 0.012) were independent risk factors for tumor recurrence. The carcinoembryonic antigen level >10 mcg/L affected OS (HR = 4.2 95% CI 2.02-16.9, p = 0.001), and the resection of more than two tumors was significantly associated with R1 margins (HR = 9.32, 95% CI 1.14-32.5, p = 0.037). DISCUSSION: Laparoscopic parenchymal-sparing surgery of CRLM does not compromise the oncological outcome, allowing a higher percentage of repeat hepatectomy. R1 margins are a risk factor for tumor recurrence but not for overall survival. The presence of multiple lesions is the only independent risk factor of R1 margins and also the major disadvantage of this technique.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree false
77 schema:isPartOf N0d8635fd8e204defbf71ee99402a9a5e
78 Nccd9d806d44e4eabbebacc72b9444838
79 sg:journal.1098220
80 schema:name Impact of surgical margins on overall and recurrence-free survival in parenchymal-sparing laparoscopic liver resections of colorectal metastases
81 schema:pagination 2736-2747
82 schema:productId N1afb9cef8aea4063b7988e23303fd1f2
83 N46fba563c11c419287134e05fc8f5bed
84 N5618d73d4c46442888cdf3853074f875
85 N5e3f876c821944d086e42c1c65a214de
86 Nb6dd40075e60473fbd4cc83a7d9aaad8
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005741749
88 https://doi.org/10.1007/s00464-014-3999-3
89 schema:sdDatePublished 2019-04-10T21:31
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher Nb7c0cd01477141709fcaa6594af7f380
92 schema:url http://link.springer.com/10.1007/s00464-014-3999-3
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N09ea113d84ea4ac8b72c838bce9ab85f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Laparoscopy
98 rdf:type schema:DefinedTerm
99 N0d8635fd8e204defbf71ee99402a9a5e schema:issueNumber 9
100 rdf:type schema:PublicationIssue
101 N107042da0d2f402dac779a16352f228b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Organ Sparing Treatments
103 rdf:type schema:DefinedTerm
104 N11a3fc184f4f4f449a1858a6adaac47f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Male
106 rdf:type schema:DefinedTerm
107 N173d8c72191c4d00a3d226bc7d7b41ac schema:name Department of General & Hepato-Biliary Surgery, Liver Transplantation Service, Ghent University Hospital and Medical School, De Pintelaan 185, 2K12 IC, 9000, Ghent, Belgium
108 rdf:type schema:Organization
109 N1afb9cef8aea4063b7988e23303fd1f2 schema:name nlm_unique_id
110 schema:value 8806653
111 rdf:type schema:PropertyValue
112 N22ff8617b9b34f33af1678a8da256bc0 rdf:first sg:person.01232015026.40
113 rdf:rest N2ecd977d06c14ed79beafd68d089894a
114 N267229ca1a0943f4b9d578f28b1be75a schema:name Department of Oncology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium
115 rdf:type schema:Organization
116 N2701054b96df4fb6ba7df7873c56df0f rdf:first sg:person.01351662764.91
117 rdf:rest N22ff8617b9b34f33af1678a8da256bc0
118 N2ecd977d06c14ed79beafd68d089894a rdf:first sg:person.01107613563.52
119 rdf:rest N67d0f7cddfd742f08a6aaa2304396a9a
120 N34a7e55e14aa48da8b62ac815da85551 rdf:first sg:person.015506075672.44
121 rdf:rest N903a4616294648f5a313ed05dad250f5
122 N358427ee60e1491c8b571401d09b9ade schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Neoplasm Recurrence, Local
124 rdf:type schema:DefinedTerm
125 N3f0f433bf9c5476281b5415f0a7cb2b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Middle Aged
127 rdf:type schema:DefinedTerm
128 N3f8e77d6196142d187860bb0858d6fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Colorectal Neoplasms
130 rdf:type schema:DefinedTerm
131 N46fba563c11c419287134e05fc8f5bed schema:name pubmed_id
132 schema:value 25427420
133 rdf:type schema:PropertyValue
134 N4ad1fa1eb3bd42d2abeb4c018cca6b33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Multivariate Analysis
136 rdf:type schema:DefinedTerm
137 N517e3a43570c40269f7e3e3c3f2b8fd0 schema:name Department of Radiology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium
138 rdf:type schema:Organization
139 N5618d73d4c46442888cdf3853074f875 schema:name doi
140 schema:value 10.1007/s00464-014-3999-3
141 rdf:type schema:PropertyValue
142 N5e3f876c821944d086e42c1c65a214de schema:name dimensions_id
143 schema:value pub.1005741749
144 rdf:type schema:PropertyValue
145 N67d0f7cddfd742f08a6aaa2304396a9a rdf:first sg:person.015044246514.80
146 rdf:rest N34a7e55e14aa48da8b62ac815da85551
147 N6cd9938628a84e08a87d9e69596237a0 schema:name Department of Pathology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium
148 rdf:type schema:Organization
149 N6e2dc76d5c874cf0858c6e8f65e6cd0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Survival Rate
151 rdf:type schema:DefinedTerm
152 N783b9226d3024b9baec3fb49f9de8226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Risk Factors
154 rdf:type schema:DefinedTerm
155 N851d3c6a23eb44f688f64805f030171a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Humans
157 rdf:type schema:DefinedTerm
158 N8938ac1e24d241ad8d7ed097d70527b0 schema:name Department of Oncology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium
159 rdf:type schema:Organization
160 N8e2a590997034017ace4e3f92efe3c05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Liver Neoplasms
162 rdf:type schema:DefinedTerm
163 N903a4616294648f5a313ed05dad250f5 rdf:first sg:person.0722345435.15
164 rdf:rest Na3e325d814284807aa9ee054bbc5fce0
165 N99e8c2bead7c4aec965cb7a8284d6610 schema:name Department of General & Hepato-Biliary Surgery, Liver Transplantation Service, Ghent University Hospital and Medical School, De Pintelaan 185, 2K12 IC, 9000, Ghent, Belgium
166 rdf:type schema:Organization
167 Na3e325d814284807aa9ee054bbc5fce0 rdf:first sg:person.0606455504.93
168 rdf:rest rdf:nil
169 Na8275702c900487598db57c6d6caddf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Retrospective Studies
171 rdf:type schema:DefinedTerm
172 Naf31e5c6754e4631b6364c73532f8fe7 schema:name Department of General & Hepato-Biliary Surgery, Liver Transplantation Service, Ghent University Hospital and Medical School, De Pintelaan 185, 2K12 IC, 9000, Ghent, Belgium
173 rdf:type schema:Organization
174 Nb6dd40075e60473fbd4cc83a7d9aaad8 schema:name readcube_id
175 schema:value 1b5b1b01c3b2f9a1a733e39c0dc0870eedd4d00fe97defe6f1516cb7bbb585ed
176 rdf:type schema:PropertyValue
177 Nb7c0cd01477141709fcaa6594af7f380 schema:name Springer Nature - SN SciGraph project
178 rdf:type schema:Organization
179 Nb869b778d0964e628897d4dbe9869e78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Hepatectomy
181 rdf:type schema:DefinedTerm
182 Nbe31ac4a76cb4a2ca4a7099ceee72204 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Follow-Up Studies
184 rdf:type schema:DefinedTerm
185 Nccd9d806d44e4eabbebacc72b9444838 schema:volumeNumber 29
186 rdf:type schema:PublicationVolume
187 Ne01085174c814948802da22f7a6f32e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Adult
189 rdf:type schema:DefinedTerm
190 Ne1d9095572314935a6a9f4f9133e08a7 rdf:first sg:person.0703074332.50
191 rdf:rest N2701054b96df4fb6ba7df7873c56df0f
192 Ne3ecd7c036674e5c8ced578084cb67ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Aged
194 rdf:type schema:DefinedTerm
195 Neab6659f7793476db749c2f869fbd925 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Disease-Free Survival
197 rdf:type schema:DefinedTerm
198 Nebc0f287794f404f8f0b8da225b392a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Aged, 80 and over
200 rdf:type schema:DefinedTerm
201 Nf1aeb57e7abd427abdf2fbea0a3ff948 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Female
203 rdf:type schema:DefinedTerm
204 Nff7fd028609e46d99085ec27bc463901 schema:name Department of Oncology, Ghent University Hospital and Medical School, De Pintelaan 185, 9000, Ghent, Belgium
205 rdf:type schema:Organization
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
210 schema:name Oncology and Carcinogenesis
211 rdf:type schema:DefinedTerm
212 sg:journal.1098220 schema:issn 0930-2794
213 1432-2218
214 schema:name Surgical Endoscopy
215 rdf:type schema:Periodical
216 sg:person.01107613563.52 schema:affiliation N517e3a43570c40269f7e3e3c3f2b8fd0
217 schema:familyName Smeets
218 schema:givenName Peter
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107613563.52
220 rdf:type schema:Person
221 sg:person.01232015026.40 schema:affiliation Nff7fd028609e46d99085ec27bc463901
222 schema:familyName Laurent
223 schema:givenName Stéphanie
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232015026.40
225 rdf:type schema:Person
226 sg:person.01351662764.91 schema:affiliation N99e8c2bead7c4aec965cb7a8284d6610
227 schema:familyName Tomassini
228 schema:givenName Federico
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351662764.91
230 rdf:type schema:Person
231 sg:person.015044246514.80 schema:affiliation N8938ac1e24d241ad8d7ed097d70527b0
232 schema:familyName De Man
233 schema:givenName Marc
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015044246514.80
235 rdf:type schema:Person
236 sg:person.015506075672.44 schema:affiliation N267229ca1a0943f4b9d578f28b1be75a
237 schema:familyName Geboes
238 schema:givenName Karen
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015506075672.44
240 rdf:type schema:Person
241 sg:person.0606455504.93 schema:affiliation N173d8c72191c4d00a3d226bc7d7b41ac
242 schema:familyName Troisi
243 schema:givenName Roberto I.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606455504.93
245 rdf:type schema:Person
246 sg:person.0703074332.50 schema:affiliation Naf31e5c6754e4631b6364c73532f8fe7
247 schema:familyName Montalti
248 schema:givenName Roberto
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703074332.50
250 rdf:type schema:Person
251 sg:person.0722345435.15 schema:affiliation N6cd9938628a84e08a87d9e69596237a0
252 schema:familyName Libbrecht
253 schema:givenName Louis J.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722345435.15
255 rdf:type schema:Person
256 sg:pub.10.1007/s00268-008-9629-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023017550
257 https://doi.org/10.1007/s00268-008-9629-2
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s00423-011-0872-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004510935
260 https://doi.org/10.1007/s00423-011-0872-x
261 rdf:type schema:CreativeWork
262 sg:pub.10.1245/s10434-007-9703-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027017713
263 https://doi.org/10.1245/s10434-007-9703-2
264 rdf:type schema:CreativeWork
265 sg:pub.10.1245/s10434-009-0770-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041943234
266 https://doi.org/10.1245/s10434-009-0770-4
267 rdf:type schema:CreativeWork
268 sg:pub.10.1245/s10434-011-2114-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022367853
269 https://doi.org/10.1245/s10434-011-2114-4
270 rdf:type schema:CreativeWork
271 sg:pub.10.1245/s10434-012-2356-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018888370
272 https://doi.org/10.1245/s10434-012-2356-9
273 rdf:type schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1076895666 schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1077179992 schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1079195975 schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1083070823 schema:CreativeWork
278 https://doi.org/10.1002/(sici)1096-9098(199810)69:2<88::aid-jso8>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014725274
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1254::aid-cncr5>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1025015403
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/bjs.1800730917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002761672
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/bjs.1800840810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054296417
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/bjs.5386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027975622
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/bjs.5762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039676320
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1002/bjs.7032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030884899
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1002/bjs.8996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053493833
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.ejso.2014.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051727177
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.jamcollsurg.2007.06.283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007152866
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.surg.2007.09.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002283817
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s1055-3207(02)00091-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000904609
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1046/j.1365-2168.1997.02743.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029679870
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1080/13651820410023987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007578253
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/annonc/mdm106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035305381
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/annonc/mds336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050986757
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1097/00000658-199804000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134761
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1097/00000658-199909000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060135098
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1097/01.sla.0000133083.54934.ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1024049438
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1097/01.sla.0000145964.08365.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022055193
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1097/01.sla.0000160703.75808.7d schema:sameAs https://app.dimensions.ai/details/publication/pub.1052575937
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1097/sla.0b013e31811ea962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010919743
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1097/sla.0b013e3181557e47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021097579
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1097/sla.0b013e31818a07f1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077797244
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1097/sla.0b013e3181b0c4df schema:sameAs https://app.dimensions.ai/details/publication/pub.1004870718
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1097/sla.0b013e318223c609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046547313
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1097/sla.0b013e31824856f5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022177341
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1097/sla.0b013e318283a4d1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051872923
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1097/sla.0b013e3182902b6e schema:sameAs https://app.dimensions.ai/details/publication/pub.1035612056
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1111/hpb.12077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044370370
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1111/hpb.12083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038353515
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1111/hpb.12204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018132111
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1111/j.1477-2574.2009.00092.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042398031
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1111/j.1477-2574.2012.00547.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052438870
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1158/1078-0432.ccr-10-3087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021709681
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1177/145749691110000110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052686674
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1200/jco.2006.09.0928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029306962
351 rdf:type schema:CreativeWork
352 https://doi.org/10.4251/wjgo.v5.i12.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072402004
353 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...