A combination of heparin and an intermittent pneumatic compression device may be more effective to prevent deep-vein thrombosis in the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-05

AUTHORS

Y. Okuda, T. Kitajima, H. Egawa, S. Hamaguchi, S. Yamaguchi, H. Yamazaki, K. Ido

ABSTRACT

BACKGROUND: The purpose of this study was to clarify the effect of a combination of heparin and an intermittent pneumatic compression device on thrombogenesis and platelet activation in the upper and lower extremities after laparoscopy. METHODS: A blinded study was performed on 30 patients. Patients were randomly injected with either heparin or physiological saline solution (PSS) subcutaneously. The intermittent compression boot was used during surgery. Plasma D-dimer (D-D), a marker of thrombogenesis, and b-thromboglobulin (b-TG), a marker of platelet activation, were measured in the upper and lower extremities. RESULTS: In the heparin group, D-Ds in the upper and lower extremities increased significantly 24 h after surgery, but they were significantly lower than those of the PSS group. b-TG in the lower extremities of patients in the PSS group increased significantly 24 h after surgery. CONCLUSION: A combination of low-molecular-weight heparin and intermittent pneumatic compression may be more effective to prevent deep-vein thrombosis in the legs. More... »

PAGES

781-784

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00464-001-8191-x

DOI

http://dx.doi.org/10.1007/s00464-001-8191-x

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11997821


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