Improvement of cordycepin production by an isolated Paecilomyces hepiali mutant from combinatorial mutation breeding and medium screening View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-07-15

AUTHORS

Xue Cai, Jie-Yi Jin, Bo Zhang, Zhi-Qiang Liu, Yu-Guo Zheng

ABSTRACT

Cordycepin is a major bioactive compound found in Cordyceps sinensis that exhibits a broad spectrum of biological activities. Here a Paecilomyces hepiali OR-1 strain was initially isolated from plateau soil for the bioproduction of cordycepin. Subsequently, strain modification including 60Co γ-ray and ultraviolet irradiation were employed to increase the cordycepin titer, resulted in a high-yield mutant strain P. hepiali ZJB18001 with the cordycepin content of 0.61 mg/gDCW, showing a 2.3-fold to that from the wild strain (0.26 mg/gDCW). Furthermore, medium screening based on Box-Behnken design and the response surface methodology facilitated the enhancement of cordycepin yield to the value of 0.96 mg/gDCW at 25 °C for 5 days in submerged cultivation with an optimized medium composition. The high cordycepin yield, rapid growth rate and stable genetic characteristics of P. hepiali ZJB18001 are beneficial in terms of costs and time for the industrialization of cordycepin production. More... »

PAGES

2387-2398

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00449-021-02611-w

DOI

http://dx.doi.org/10.1007/s00449-021-02611-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1139724408

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34268619


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