Gene expression of sex steroid metabolizing enzymes and receptors in the skeletal muscle of migrant and resident subspecies of white-crowned ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-06-22

AUTHORS

Jesse S. Krause, Trevor Watkins, Angus M. A. Reid, Jeffrey C. Cheah, Jonathan H. Pérez, Valerie R. Bishop, Marilyn Ramenofsky, John C. Wingfield, Simone L. Meddle

ABSTRACT

Circulating sex steroid concentrations vary dramatically across the year in seasonally breeding animals. The ability of circulating sex steroids to effect muscle function can be modulated by changes in intracellular expression of steroid metabolizing enzymes (e.g., 5α-reductase type 2 and aromatase) and receptors. Together, these combined changes in plasma hormones, metabolizing enzymes and receptors allow for seasonally appropriate changes in skeletal muscle function. We tested the hypothesis that gene expression of sex steroid metabolizing enzymes and receptors would vary seasonally in skeletal muscle and these changes would differ between a migrant and resident life history strategy. We quantified annual changes in plasma testosterone and gene expression in pectoralis and gastrocnemius skeletal muscles using quantitative polymerase chain reaction (qPCR) in free-living migrant (Zonotrichia leucophrys gambelii) and resident (Z. l. nuttalli) subspecies of white-crowned sparrow during breeding, pre-basic molt, and wintering life history stages. Pectoralis muscle profile was largest in migrants during breeding, while residents maintained large muscle profiles year-round. Circulating testosterone peaked during breeding in both subspecies. Pectoralis muscle androgen receptor mRNA expression was lower in females of both subspecies during breeding. Estrogen receptor-α expression was higher in the pectoralis muscle, but not gastrocnemius, of residents throughout the annual cycle when compared to migrants. Pectoralis aromatase expression was higher in resident males compared to migrant males. No differences were observed for 5α-reductase 2. Between these two subspecies, patterns of plasma testosterone and androgen receptors appear to be conserved, however estrogen receptor gene expression appears to have diverged. More... »

PAGES

549-562

References to SciGraph publications

  • 1988-03. Comparative aspects of fibre types, areas, and capillary supply in the pectoralis muscle of some passerine birds with differing migratory behaviour in JOURNAL OF COMPARATIVE PHYSIOLOGY B
  • 2004-10. Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types in ENDOCRINE
  • 2011-10-07. Analysis of Skeletal Muscle Hypertrophy in Models of Increased Loading in MYOGENESIS
  • 2013-07-26. How Sex Hormones Promote Skeletal Muscle Regeneration in SPORTS MEDICINE
  • 2015-10-01. Breeding on the leading edge of a northward range expansion: differences in morphology and the stress response in the arctic Gambel’s white-crowned sparrow in OECOLOGIA
  • 2017-08-04. Extreme spring conditions in the Arctic delay spring phenology of long-distance migratory songbirds in OECOLOGIA
  • 1979-11. The use of space by white-crowned sparrows: Juvenile and adult ranging patterns and home range versus body size comparisons in an avian granivore community in BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
  • 1985-07. Seasonal variation in catabolic enzyme activities in breast muscle of some migratory birds in OECOLOGIA
  • 2018-12-08. Preparing to migrate: expression of androgen signaling molecules and insulin-like growth factor-1 in skeletal muscles of Gambel’s white-crowned sparrows in JOURNAL OF COMPARATIVE PHYSIOLOGY A
  • 2020-03-05. Autumn migratory departure is influenced by reproductive timing and weather in an Arctic passerine in JOURNAL OF ORNITHOLOGY
  • 2017-11-15. The evolution of androgen receptor expression and behavior in Anolis lizard forelimb muscles in JOURNAL OF COMPARATIVE PHYSIOLOGY A
  • 2019-07-10. Migration pattern of Gambel’s White-crowned Sparrow along the Pacific Flyway in JOURNAL OF ORNITHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00442-022-05204-w

    DOI

    http://dx.doi.org/10.1007/s00442-022-05204-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1148871056

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35732927


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aromatase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Muscle, Skeletal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Estrogen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Seasons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sparrows", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Testosterone", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Department of Biology, University of Nevada Reno, 1664 N. Virginia Street, Sarah Fleischmann 109, 89557, Reno, NV, USA", 
                "Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krause", 
            "givenName": "Jesse S.", 
            "id": "sg:person.01274275443.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274275443.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, University of Nevada Reno, 1664 N. Virginia Street, Sarah Fleischmann 109, 89557, Reno, NV, USA", 
              "id": "http://www.grid.ac/institutes/grid.266818.3", 
              "name": [
                "Department of Biology, University of Nevada Reno, 1664 N. Virginia Street, Sarah Fleischmann 109, 89557, Reno, NV, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watkins", 
            "givenName": "Trevor", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Roslin Institute, University of Edinburgh, EH25 9RG, Midlothian, Scotland, UK", 
              "id": "http://www.grid.ac/institutes/grid.482685.5", 
              "name": [
                "Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, EH4 2XU, Edinburgh, Scotland, UK", 
                "The Roslin Institute, University of Edinburgh, EH25 9RG, Midlothian, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reid", 
            "givenName": "Angus M. A.", 
            "id": "sg:person.016132362543.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016132362543.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cheah", 
            "givenName": "Jeffrey C.", 
            "id": "sg:person.012544110207.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012544110207.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, University of South Alabama, 36688, Mobile, AL, USA", 
              "id": "http://www.grid.ac/institutes/grid.267153.4", 
              "name": [
                "Department of Biology, University of South Alabama, 36688, Mobile, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "P\u00e9rez", 
            "givenName": "Jonathan H.", 
            "id": "sg:person.0727436015.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727436015.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Roslin Institute, University of Edinburgh, EH25 9RG, Midlothian, Scotland, UK", 
              "id": "http://www.grid.ac/institutes/grid.482685.5", 
              "name": [
                "The Roslin Institute, University of Edinburgh, EH25 9RG, Midlothian, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bishop", 
            "givenName": "Valerie R.", 
            "id": "sg:person.0601767010.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601767010.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramenofsky", 
            "givenName": "Marilyn", 
            "id": "sg:person.01351333700.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351333700.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wingfield", 
            "givenName": "John C.", 
            "id": "sg:person.0752057552.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752057552.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Roslin Institute, University of Edinburgh, EH25 9RG, Midlothian, Scotland, UK", 
              "id": "http://www.grid.ac/institutes/grid.482685.5", 
              "name": [
                "The Roslin Institute, University of Edinburgh, EH25 9RG, Midlothian, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meddle", 
            "givenName": "Simone L.", 
            "id": "sg:person.01205551206.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205551206.63"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00359-017-1228-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092692603", 
              "https://doi.org/10.1007/s00359-017-1228-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10336-019-01685-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1117922277", 
              "https://doi.org/10.1007/s10336-019-01685-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00442-017-3907-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090991363", 
              "https://doi.org/10.1007/s00442-017-3907-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00379335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046252707", 
              "https://doi.org/10.1007/bf00379335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40279-013-0081-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005487177", 
              "https://doi.org/10.1007/s40279-013-0081-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01075830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038202452", 
              "https://doi.org/10.1007/bf01075830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/endo:25:1:27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030886802", 
              "https://doi.org/10.1385/endo:25:1:27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-343-1_12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031725187", 
              "https://doi.org/10.1007/978-1-61779-343-1_12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10336-020-01754-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1125398389", 
              "https://doi.org/10.1007/s10336-020-01754-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00293244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021451795", 
              "https://doi.org/10.1007/bf00293244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00442-015-3447-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017337625", 
              "https://doi.org/10.1007/s00442-015-3447-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00359-018-1308-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110481073", 
              "https://doi.org/10.1007/s00359-018-1308-7"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-06-22", 
        "datePublishedReg": "2022-06-22", 
        "description": "Circulating sex steroid concentrations vary dramatically across the year in seasonally breeding animals. The ability of circulating sex steroids to effect muscle function can be modulated by changes in intracellular expression of steroid metabolizing enzymes (e.g., 5\u03b1-reductase type 2 and aromatase) and receptors. Together, these combined changes in plasma hormones, metabolizing enzymes and receptors allow for seasonally appropriate changes in skeletal muscle function. We tested the hypothesis that gene expression of sex steroid metabolizing enzymes and receptors would vary seasonally in skeletal muscle and these changes would differ between a migrant and resident life history strategy. We quantified annual changes in plasma testosterone and gene expression in pectoralis and gastrocnemius skeletal muscles using quantitative polymerase chain reaction (qPCR) in free-living migrant (Zonotrichia leucophrys gambelii) and resident (Z. l. nuttalli) subspecies of white-crowned sparrow during breeding, pre-basic molt, and wintering life history stages. Pectoralis muscle profile was largest in migrants during breeding, while residents maintained large muscle profiles year-round. Circulating testosterone peaked during breeding in both subspecies. Pectoralis muscle androgen receptor mRNA expression was lower in females of both subspecies during breeding. Estrogen receptor-\u03b1 expression was higher in the pectoralis muscle, but not gastrocnemius, of residents throughout the annual cycle when compared to migrants. Pectoralis aromatase expression was higher in resident males compared to migrant males. No differences were observed for 5\u03b1-reductase 2. Between these two subspecies, patterns of plasma testosterone and androgen receptors appear to be conserved, however estrogen receptor gene expression appears to have diverged.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00442-022-05204-w", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5300975", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2997773", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1009586", 
            "issn": [
              "0029-8549", 
              "1432-1939"
            ], 
            "name": "Oecologia", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "199"
          }
        ], 
        "keywords": [
          "sex steroids", 
          "quantitative polymerase chain reaction", 
          "muscle function", 
          "skeletal muscle", 
          "plasma testosterone", 
          "androgen receptor mRNA expression", 
          "estrogen receptor gene expression", 
          "receptor mRNA expression", 
          "skeletal muscle function", 
          "sex steroid concentrations", 
          "receptor gene expression", 
          "muscle profile", 
          "gene expression", 
          "polymerase chain reaction", 
          "androgen receptor", 
          "plasma hormones", 
          "aromatase expression", 
          "steroid concentrations", 
          "mRNA expression", 
          "steroids", 
          "intracellular expression", 
          "testosterone", 
          "receptors", 
          "pectoralis muscle", 
          "muscle", 
          "chain reaction", 
          "expression", 
          "males", 
          "annual changes", 
          "estrogen", 
          "hormone", 
          "residents", 
          "pectoralis", 
          "enzyme", 
          "changes", 
          "females", 
          "animals", 
          "appropriate changes", 
          "profile", 
          "years", 
          "function", 
          "migrant males", 
          "differences", 
          "hypothesis", 
          "concentration", 
          "breeding animals", 
          "stage", 
          "patterns", 
          "ability", 
          "strategies", 
          "pre-basic molt", 
          "resident subspecies", 
          "free-living migrants", 
          "moult", 
          "resident males", 
          "cycle", 
          "sparrows", 
          "reaction", 
          "migrants", 
          "subspecies", 
          "life history strategies", 
          "life history stages", 
          "history strategies", 
          "history stages", 
          "breeding", 
          "annual cycle"
        ], 
        "name": "Gene expression of sex steroid metabolizing enzymes and receptors in the skeletal muscle of migrant and resident subspecies of white-crowned sparrow (Zonotrichia leucophrys)", 
        "pagination": "549-562", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1148871056"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00442-022-05204-w"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35732927"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00442-022-05204-w", 
          "https://app.dimensions.ai/details/publication/pub.1148871056"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:50", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_956.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00442-022-05204-w"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00442-022-05204-w'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00442-022-05204-w'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00442-022-05204-w'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00442-022-05204-w'


     

    This table displays all metadata directly associated to this object as RDF triples.

    285 TRIPLES      21 PREDICATES      113 URIs      93 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00442-022-05204-w schema:about N109841cbf5084df4a9ff64180822c5ca
    2 N60dcc7cb9fd14b34bdca435c0f20d587
    3 N62dfcb0837fe414c805e0a6342c55b97
    4 N765f997e242b4b8abc2826a279e66c43
    5 N78bff8bea0164b40ae46a13ade55a35f
    6 N7d1692c28f0c4e8bbb5664a3ad8d2bfd
    7 N964131bb0a1348889084828e09f2edbd
    8 Nb6db886bc6f34c88aab62eb1fff91fb2
    9 Nc6e039b2458444b6b3e679bce0e29688
    10 Ncb07358134754ce68a519b09ad6113b6
    11 anzsrc-for:06
    12 anzsrc-for:0604
    13 schema:author Na9b5a5af1e8e46c4989ba52b2157e660
    14 schema:citation sg:pub.10.1007/978-1-61779-343-1_12
    15 sg:pub.10.1007/bf00293244
    16 sg:pub.10.1007/bf00379335
    17 sg:pub.10.1007/bf01075830
    18 sg:pub.10.1007/s00359-017-1228-y
    19 sg:pub.10.1007/s00359-018-1308-7
    20 sg:pub.10.1007/s00442-015-3447-7
    21 sg:pub.10.1007/s00442-017-3907-3
    22 sg:pub.10.1007/s10336-019-01685-4
    23 sg:pub.10.1007/s10336-020-01754-z
    24 sg:pub.10.1007/s40279-013-0081-6
    25 sg:pub.10.1385/endo:25:1:27
    26 schema:datePublished 2022-06-22
    27 schema:datePublishedReg 2022-06-22
    28 schema:description Circulating sex steroid concentrations vary dramatically across the year in seasonally breeding animals. The ability of circulating sex steroids to effect muscle function can be modulated by changes in intracellular expression of steroid metabolizing enzymes (e.g., 5α-reductase type 2 and aromatase) and receptors. Together, these combined changes in plasma hormones, metabolizing enzymes and receptors allow for seasonally appropriate changes in skeletal muscle function. We tested the hypothesis that gene expression of sex steroid metabolizing enzymes and receptors would vary seasonally in skeletal muscle and these changes would differ between a migrant and resident life history strategy. We quantified annual changes in plasma testosterone and gene expression in pectoralis and gastrocnemius skeletal muscles using quantitative polymerase chain reaction (qPCR) in free-living migrant (Zonotrichia leucophrys gambelii) and resident (Z. l. nuttalli) subspecies of white-crowned sparrow during breeding, pre-basic molt, and wintering life history stages. Pectoralis muscle profile was largest in migrants during breeding, while residents maintained large muscle profiles year-round. Circulating testosterone peaked during breeding in both subspecies. Pectoralis muscle androgen receptor mRNA expression was lower in females of both subspecies during breeding. Estrogen receptor-α expression was higher in the pectoralis muscle, but not gastrocnemius, of residents throughout the annual cycle when compared to migrants. Pectoralis aromatase expression was higher in resident males compared to migrant males. No differences were observed for 5α-reductase 2. Between these two subspecies, patterns of plasma testosterone and androgen receptors appear to be conserved, however estrogen receptor gene expression appears to have diverged.
    29 schema:genre article
    30 schema:isAccessibleForFree false
    31 schema:isPartOf N04f2354f5d5e416ebb16d24135f07b57
    32 N3f676c6367164fedacd98fc4a064f21f
    33 sg:journal.1009586
    34 schema:keywords ability
    35 androgen receptor
    36 androgen receptor mRNA expression
    37 animals
    38 annual changes
    39 annual cycle
    40 appropriate changes
    41 aromatase expression
    42 breeding
    43 breeding animals
    44 chain reaction
    45 changes
    46 concentration
    47 cycle
    48 differences
    49 enzyme
    50 estrogen
    51 estrogen receptor gene expression
    52 expression
    53 females
    54 free-living migrants
    55 function
    56 gene expression
    57 history stages
    58 history strategies
    59 hormone
    60 hypothesis
    61 intracellular expression
    62 life history stages
    63 life history strategies
    64 mRNA expression
    65 males
    66 migrant males
    67 migrants
    68 moult
    69 muscle
    70 muscle function
    71 muscle profile
    72 patterns
    73 pectoralis
    74 pectoralis muscle
    75 plasma hormones
    76 plasma testosterone
    77 polymerase chain reaction
    78 pre-basic molt
    79 profile
    80 quantitative polymerase chain reaction
    81 reaction
    82 receptor gene expression
    83 receptor mRNA expression
    84 receptors
    85 resident males
    86 resident subspecies
    87 residents
    88 sex steroid concentrations
    89 sex steroids
    90 skeletal muscle
    91 skeletal muscle function
    92 sparrows
    93 stage
    94 steroid concentrations
    95 steroids
    96 strategies
    97 subspecies
    98 testosterone
    99 years
    100 schema:name Gene expression of sex steroid metabolizing enzymes and receptors in the skeletal muscle of migrant and resident subspecies of white-crowned sparrow (Zonotrichia leucophrys)
    101 schema:pagination 549-562
    102 schema:productId N48b41cdc3ef94aa0b3d111e18f904d07
    103 N525dc1e0a5f148e995fa52eaab0efd45
    104 Nb53d01173fc34771852d43e3ca091836
    105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1148871056
    106 https://doi.org/10.1007/s00442-022-05204-w
    107 schema:sdDatePublished 2022-10-01T06:50
    108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    109 schema:sdPublisher Na4ed242a11684442b4d9c49711eb0f8a
    110 schema:url https://doi.org/10.1007/s00442-022-05204-w
    111 sgo:license sg:explorer/license/
    112 sgo:sdDataset articles
    113 rdf:type schema:ScholarlyArticle
    114 N04f2354f5d5e416ebb16d24135f07b57 schema:volumeNumber 199
    115 rdf:type schema:PublicationVolume
    116 N0a01fdeb7e664c74958a6e68f665f7db rdf:first sg:person.0727436015.63
    117 rdf:rest Nb1a7d6e4d9c44075a91f1c37625f9d9f
    118 N0e762f8e98a541e891f4db0982e351e3 rdf:first sg:person.01205551206.63
    119 rdf:rest rdf:nil
    120 N109841cbf5084df4a9ff64180822c5ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Testosterone
    122 rdf:type schema:DefinedTerm
    123 N3f676c6367164fedacd98fc4a064f21f schema:issueNumber 3
    124 rdf:type schema:PublicationIssue
    125 N4261bbfe318148b5896151ffcfff62f7 rdf:first sg:person.0752057552.69
    126 rdf:rest N0e762f8e98a541e891f4db0982e351e3
    127 N48b41cdc3ef94aa0b3d111e18f904d07 schema:name dimensions_id
    128 schema:value pub.1148871056
    129 rdf:type schema:PropertyValue
    130 N525dc1e0a5f148e995fa52eaab0efd45 schema:name doi
    131 schema:value 10.1007/s00442-022-05204-w
    132 rdf:type schema:PropertyValue
    133 N60dcc7cb9fd14b34bdca435c0f20d587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Male
    135 rdf:type schema:DefinedTerm
    136 N62dfcb0837fe414c805e0a6342c55b97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Female
    138 rdf:type schema:DefinedTerm
    139 N71e62b70d2d14306b528387b7fb5f858 schema:affiliation grid-institutes:grid.266818.3
    140 schema:familyName Watkins
    141 schema:givenName Trevor
    142 rdf:type schema:Person
    143 N765f997e242b4b8abc2826a279e66c43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Sparrows
    145 rdf:type schema:DefinedTerm
    146 N78bff8bea0164b40ae46a13ade55a35f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Seasons
    148 rdf:type schema:DefinedTerm
    149 N7d1692c28f0c4e8bbb5664a3ad8d2bfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Gene Expression
    151 rdf:type schema:DefinedTerm
    152 N964131bb0a1348889084828e09f2edbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Animals
    154 rdf:type schema:DefinedTerm
    155 N9679c9cd112746379bdc725968013041 rdf:first sg:person.012544110207.07
    156 rdf:rest N0a01fdeb7e664c74958a6e68f665f7db
    157 Na4ed242a11684442b4d9c49711eb0f8a schema:name Springer Nature - SN SciGraph project
    158 rdf:type schema:Organization
    159 Na9b5a5af1e8e46c4989ba52b2157e660 rdf:first sg:person.01274275443.98
    160 rdf:rest Nfeb08ae18bc541d29babfc8dc92db172
    161 Nb1a7d6e4d9c44075a91f1c37625f9d9f rdf:first sg:person.0601767010.90
    162 rdf:rest Nb4d7712b32d4447294ca25aed447daae
    163 Nb4d7712b32d4447294ca25aed447daae rdf:first sg:person.01351333700.81
    164 rdf:rest N4261bbfe318148b5896151ffcfff62f7
    165 Nb53d01173fc34771852d43e3ca091836 schema:name pubmed_id
    166 schema:value 35732927
    167 rdf:type schema:PropertyValue
    168 Nb6db886bc6f34c88aab62eb1fff91fb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Aromatase
    170 rdf:type schema:DefinedTerm
    171 Nc6e039b2458444b6b3e679bce0e29688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Muscle, Skeletal
    173 rdf:type schema:DefinedTerm
    174 Ncb07358134754ce68a519b09ad6113b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Receptors, Estrogen
    176 rdf:type schema:DefinedTerm
    177 Ne9a7a94ef68642f59f0fa358e3129887 rdf:first sg:person.016132362543.32
    178 rdf:rest N9679c9cd112746379bdc725968013041
    179 Nfeb08ae18bc541d29babfc8dc92db172 rdf:first N71e62b70d2d14306b528387b7fb5f858
    180 rdf:rest Ne9a7a94ef68642f59f0fa358e3129887
    181 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Biological Sciences
    183 rdf:type schema:DefinedTerm
    184 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    185 schema:name Genetics
    186 rdf:type schema:DefinedTerm
    187 sg:grant.2997773 http://pending.schema.org/fundedItem sg:pub.10.1007/s00442-022-05204-w
    188 rdf:type schema:MonetaryGrant
    189 sg:grant.5300975 http://pending.schema.org/fundedItem sg:pub.10.1007/s00442-022-05204-w
    190 rdf:type schema:MonetaryGrant
    191 sg:journal.1009586 schema:issn 0029-8549
    192 1432-1939
    193 schema:name Oecologia
    194 schema:publisher Springer Nature
    195 rdf:type schema:Periodical
    196 sg:person.01205551206.63 schema:affiliation grid-institutes:grid.482685.5
    197 schema:familyName Meddle
    198 schema:givenName Simone L.
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205551206.63
    200 rdf:type schema:Person
    201 sg:person.012544110207.07 schema:affiliation grid-institutes:grid.27860.3b
    202 schema:familyName Cheah
    203 schema:givenName Jeffrey C.
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012544110207.07
    205 rdf:type schema:Person
    206 sg:person.01274275443.98 schema:affiliation grid-institutes:grid.27860.3b
    207 schema:familyName Krause
    208 schema:givenName Jesse S.
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274275443.98
    210 rdf:type schema:Person
    211 sg:person.01351333700.81 schema:affiliation grid-institutes:grid.27860.3b
    212 schema:familyName Ramenofsky
    213 schema:givenName Marilyn
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351333700.81
    215 rdf:type schema:Person
    216 sg:person.016132362543.32 schema:affiliation grid-institutes:grid.482685.5
    217 schema:familyName Reid
    218 schema:givenName Angus M. A.
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016132362543.32
    220 rdf:type schema:Person
    221 sg:person.0601767010.90 schema:affiliation grid-institutes:grid.482685.5
    222 schema:familyName Bishop
    223 schema:givenName Valerie R.
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601767010.90
    225 rdf:type schema:Person
    226 sg:person.0727436015.63 schema:affiliation grid-institutes:grid.267153.4
    227 schema:familyName Pérez
    228 schema:givenName Jonathan H.
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727436015.63
    230 rdf:type schema:Person
    231 sg:person.0752057552.69 schema:affiliation grid-institutes:grid.27860.3b
    232 schema:familyName Wingfield
    233 schema:givenName John C.
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752057552.69
    235 rdf:type schema:Person
    236 sg:pub.10.1007/978-1-61779-343-1_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031725187
    237 https://doi.org/10.1007/978-1-61779-343-1_12
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/bf00293244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021451795
    240 https://doi.org/10.1007/bf00293244
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/bf00379335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046252707
    243 https://doi.org/10.1007/bf00379335
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/bf01075830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038202452
    246 https://doi.org/10.1007/bf01075830
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/s00359-017-1228-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1092692603
    249 https://doi.org/10.1007/s00359-017-1228-y
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s00359-018-1308-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110481073
    252 https://doi.org/10.1007/s00359-018-1308-7
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/s00442-015-3447-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017337625
    255 https://doi.org/10.1007/s00442-015-3447-7
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/s00442-017-3907-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090991363
    258 https://doi.org/10.1007/s00442-017-3907-3
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s10336-019-01685-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117922277
    261 https://doi.org/10.1007/s10336-019-01685-4
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s10336-020-01754-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1125398389
    264 https://doi.org/10.1007/s10336-020-01754-z
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s40279-013-0081-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005487177
    267 https://doi.org/10.1007/s40279-013-0081-6
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1385/endo:25:1:27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030886802
    270 https://doi.org/10.1385/endo:25:1:27
    271 rdf:type schema:CreativeWork
    272 grid-institutes:grid.266818.3 schema:alternateName Department of Biology, University of Nevada Reno, 1664 N. Virginia Street, Sarah Fleischmann 109, 89557, Reno, NV, USA
    273 schema:name Department of Biology, University of Nevada Reno, 1664 N. Virginia Street, Sarah Fleischmann 109, 89557, Reno, NV, USA
    274 rdf:type schema:Organization
    275 grid-institutes:grid.267153.4 schema:alternateName Department of Biology, University of South Alabama, 36688, Mobile, AL, USA
    276 schema:name Department of Biology, University of South Alabama, 36688, Mobile, AL, USA
    277 rdf:type schema:Organization
    278 grid-institutes:grid.27860.3b schema:alternateName Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA
    279 schema:name Department of Biology, University of Nevada Reno, 1664 N. Virginia Street, Sarah Fleischmann 109, 89557, Reno, NV, USA
    280 Department of Neurobiology Physiology Behavior, University of California, 95616, Davis, CA, USA
    281 rdf:type schema:Organization
    282 grid-institutes:grid.482685.5 schema:alternateName The Roslin Institute, University of Edinburgh, EH25 9RG, Midlothian, Scotland, UK
    283 schema:name Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, EH4 2XU, Edinburgh, Scotland, UK
    284 The Roslin Institute, University of Edinburgh, EH25 9RG, Midlothian, Scotland, UK
    285 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...